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ChemicalBook >> CAS DataBase List >>19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide

19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide

19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide Structure
19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide structure
CAS No.
1414455-21-2
Chemical Name:
19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide
Synonyms
IBL-302;19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide
CBNumber:
CB38190885
Molecular Formula:
C25H18FN5O4S3
Molecular Weight:
567.64
MDL Number:
MOL File:
1414455-21-2.mol
MSDS File:
SDS
Last updated:2025-04-18 09:52:11
Request For Quotation

19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide Properties

Density 1.485±0.06 g/cm3(Predicted)
pka 5.46±0.20(Predicted)
form Solid
color Off-white to light yellow

19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0906607 IBL-302 98.21% 1414455-21-2 1mg $422 2026-06-04 Buy
ChemScene CS-0906607 IBL-302 98.21% 1414455-21-2 5mg $1062 2026-06-04 Buy
ChemScene CS-0906607 IBL-302 98.21% 1414455-21-2 10mg $1885 2026-06-04 Buy
ChemScene CS-0906607 IBL-302 98.21% 1414455-21-2 25mg $3770 2026-06-04 Buy
aablocks AA02EOD9 IBL-302 >98% 1414455-21-2 1mg $469 2026-06-03 Buy
Product number Packaging Price Buy
CS-0906607 1mg $422 Buy
CS-0906607 5mg $1062 Buy
CS-0906607 10mg $1885 Buy
CS-0906607 25mg $3770 Buy
AA02EOD9 1mg $469 Buy

19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide Chemical Properties, Uses, Production

Uses

IBL-302 (AMU302) is an orally available dual-signaling inhibitor of PIM and PI3K/AKT/mTOR with activity against breast cancer and neuroblastoma. IBL-302 demonstrated in vivo efficacy in a nude mouse xenograft model, inhibiting trastuzumab (HY-P9907) resistance challenges. IBL-302 also enhances the effects of common cytotoxic chemotherapy drugs cisplatin (HY-17394), doxorubicin (HY-15142A), and etoposide (HY-13629)[1][2][3].

References

[1] Kennedy SP et al. Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer. Oncogene. 2020 Apr;39(14):3028-3040. DOI:10.1038/s41388-020-1202-y
[2] Kennedy S P, et al. Evaluation of dual-acting PIM/PI3K inhibitor IBL-302 in preclinical breast cancer models[J]. Cancer Research, 2018, 78(13_Supplement): 2932-2932.
[3] Martínez-González S, et al. Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors. ACS Med Chem Lett. 2021 Nov 2;12(11):1794-1801. DOI:10.1021/acsmedchemlett.1c00412

19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide Preparation Products And Raw materials

Raw materials

Preparation Products

19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide Suppliers

Global Suppliers ( 2)
Supplier Tel Email Country ProdList Advantage
Guangzhou Younan Technology Co., Ltd 020-82000279 18988941452 YN_research@163.com China 2984 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
Guangzhou Younan Technology Co., Ltd 58
TargetMol Chemicals Inc. 58

1414455-21-2 (19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide) Related Search:

MCX?28 19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide Rapamycin Y-27632 AKT2 Protein, HUMAN (ACTIVE, SF9, GST)
AKT3 Protein, HUMAN (ACTIVE, SF9, GST)

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19H-22,25-Epithio-4,6:7,11:14,18-trimetheno-12H-pyrimido[5,4-j][1,9,2,5,17]dithiatriazacyclotricosin-19-one, 17-fluoro-20,21-dihydro-10-methoxy-29-methyl-, 13,13-dioxide IBL-302 1414455-21-2 C25H18FN5O4S3