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3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine

3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine structure

CAS No.: 878194-92-4

Chemical Name:: 3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine

Synonyms: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile;3-Cyanopyridine-4-boronic;3-Cyano-4-pyridineboronic Acid Pinacol Ester;REF DUPL: 3-Cyanopyridine-4-boronic acid, pinacol ester;3-Cyanopyridine-4-boronic acid pinacol ester, tech. 90%;3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinecarbonitrile;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile;3-Pyridinecarbonitrile, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE ISO 9001：2015 REACH

CBNumber:: CB3836756

Molecular Formula:: C12H15BN2O2

Molecular Weight:: 230.07

MDL Number:: MFCD09037481

MOL File:: 878194-92-4.mol

MSDS File:: SDS

Last updated:2026-09-12 18:52:13

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3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine Properties

Melting point	97-99℃
Boiling point	369.6±27.0 °C(Predicted)
Density	1.10±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	solid
pka	0.95±0.20(Predicted)
color	Light green

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Warning

Hazard statements

H301-H315-H319-H335

Precautionary statements

P261-P280a-P301+P310a-P305+P351+P338-P405-P501a

HS Code

2933399990

NFPA 704

	0
2		0

3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	076902	3-Cyanopyridine-4-boronic acid pinacol ester	878194-92-4	250.00mg	$61	2026-05-18	Buy
Matrix Scientific	076902	3-Cyanopyridine-4-boronic acid pinacol ester	878194-92-4	1.00g	$111	2026-05-18	Buy
Matrix Scientific	076902	3-Cyanopyridine-4-boronic acid pinacol ester	878194-92-4	5.00g	$407	2026-05-18	Buy
Synthonix	C55955	3-Cyano-4-pyridineboronic Acid Pinacol Ester 98%	878194-92-4	100mg	$150	2026-05-06	Buy
Synthonix	C55955	3-Cyano-4-pyridineboronic Acid Pinacol Ester 98%	878194-92-4	250mg	$210	2026-05-06	Buy

Product number	Packaging	Price	Buy
076902	250.00mg	$61	Buy
076902	1.00g	$111	Buy
076902	5.00g	$407	Buy
C55955	100mg	$150	Buy
C55955	250mg	$210	Buy

3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine Chemical Properties, Uses, Production

Uses

3-Cyanopyridine-4-boronic acid pinacol ester

Synthesis

100-54-9

76-09-5

3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE

878194-92-4

In a dry 500 mL three-necked flask protected by nitrogen, 2,2,6,6-tetramethylpiperidine (57.6 mmol) was dissolved in anhydrous tetrahydrofuran (200 mL), and after the reaction system was cooled to -10 °C, n-butyllithium (57.6 mmol, 2.5 M hexane solution) was added slowly and dropwise over a period of 2 minutes. After the dropwise addition, stirring was continued for 10 min, followed by cooling the reaction system to -78 °C. Triisopropyl borate (65.3 mmol) was added within 2 min at -78 °C and stirred for 5 min at this temperature. Then, 3-cyanopyridine (48 mmol) dissolved in anhydrous tetrahydrofuran (50 mL) was added with a dropwise addition time of 5 minutes. The reaction mixture was slowly warmed to room temperature in a dry ice bath and stirred overnight. Upon completion of the reaction, the reaction was quenched with glacial acetic acid (67.2 mmol) followed by the addition of pinacol (72 mmol). Stirring was continued for 2 hours at room temperature. The reaction mixture was transferred to a dispensing funnel, diluted by adding dichloromethane (75 mL) and washed with 10% w/v aqueous potassium dihydrogen phosphate solution (4 x 60 mL). The aqueous phase was back-extracted once with dichloromethane (15 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was concentrated under reduced pressure to afford the target product 3-cyano-4-pyridineboronic acid pinacol ester (3b) as a yellow solid in 18% yield with a melting point of 88°C. The product was analyzed by IR, 1H NMR and 1H NDT. The product was characterized by IR, 1H NMR and 13C NMR to confirm the structure.

References

[1] Tetrahedron, 2011, vol. 67, # 32, p. 5806 - 5810

3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine synthesis

Synthesis of 3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine from 3-Cyanopyridine and Pinacol

3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine Preparation Products And Raw materials

Raw materials

3-Cyanopyridin-4-ylboronic acid 3-Cyanopyridine Tetrahydrofuran Pinacol Acetic acid

Hexane Triisopropyl borate

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Preparation Products

3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine Suppliers

Global Suppliers ( 77)

Supplier	Tel	Email	Country	ProdList	Advantage
Zhuhai Aobokai Biomedical Technology Co., Ltd.	400-0628126	sales-team@aobchem.com.cn	China	9998	58
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7881	64
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55
Shanghai Yolne Chemical Co., Ltd.	021-62960152	934678158@qq.com	China	9886	55
SINO High Goal Chemical Technology Co., Ltd.	021-57646680 18306277365	sunkai@chembiobanksh.com	China	2039	55

Supplier	Advantage
Zhuhai Aobokai Biomedical Technology Co., Ltd.	58
Alfa Aesar	84
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Tetranov Biopharm	64
Shanghai Longsheng chemical Co.,Ltd.	59
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	55
Shanghai Yolne Chemical Co., Ltd.	55
SINO High Goal Chemical Technology Co., Ltd.	55

View Latest Price from 3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-06-25	3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 878194-92-4	$1.10	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
	2019-12-27	3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 878194-92-4		1KG	99%	100KG	Career Henan Chemical Co

3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
878194-92-4
$1.10
99.0% min
Shaanxi Dideu Medichem Co. Ltd

3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
878194-92-4
$0.00
99%
Career Henan Chemical Co

878194-92-4 (3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine) Related Search:

3-Cyanopyridin-4-ylboronic acid 3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine 2-Chloro-3-cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine 3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine 3,5-Dimethylpyridine-4-boronic acid pinacol ester

5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile

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3-Cyanopyridine-4-boronic acid pinacol ester, tech. 90% REF DUPL: 3-Cyanopyridine-4-boronic acid, pinacol ester 3-Cyano-4-pyridineboronic Acid Pinacol Ester 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinecarbonitrile 3-Pyridinecarbonitrile, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE ISO 9001：2015 REACH 3-Cyanopyridine-4-boronic 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile 3-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine 878194-92-4