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ChemicalBook >> CAS DataBase List >>1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide

1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide

1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide Structure
1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide structure
CAS No.
180046-99-5
Chemical Name:
1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide
Synonyms
SDZ NKT 343;1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide;L-Alaninamide, 1-[[(2-nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-
CBNumber:
CB3839272
Molecular Formula:
C33H33N5O5
Molecular Weight:
579.65
MDL Number:
MFCD00949605
MOL File:
180046-99-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:13
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1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide Properties

Boiling point 892.8±65.0 °C(Predicted)
Density 1.327±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble to 100 mM in DMSO and to 100 mM in ethanol
form Powder
pka 11.66±0.70(Predicted)

1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 256646 SDZ NKT 343 Asreported 180046-99-5 10mg $588 2026-06-03 Buy
ChemScene CS-0028929 SDZ NKT 343 180046-99-5 5mg $447 2026-06-04 Buy
ChemScene CS-0028929 SDZ NKT 343 180046-99-5 10mg $715 2026-06-04 Buy
ApexBio Technology B7039 SDZ NKT 343 180046-99-5 10mg $616 2026-05-06 Buy
aablocks AA0021L4 (S)-N2-((S)-1-(benzyl(methyl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-N1-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide 180046-99-5 10mg $835 2026-05-28 Buy
Product number Packaging Price Buy
256646 10mg $588 Buy
CS-0028929 5mg $447 Buy
CS-0028929 10mg $715 Buy
B7039 10mg $616 Buy
AA0021L4 10mg $835 Buy

1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide Chemical Properties, Uses, Production

Uses

SDZ NKT 343 is a potent human NK1 tachykinin receptor antagonist.

Biological Activity

Highly selective human tachykinin NK 1 receptor antagonist (IC 50 values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK 2 and NK 3 receptors. Potently antagonizes SP-induced Ca 2+ efflux in vitro and inhibits mechanical hyperalgesia in vivo .

in vivo

SDZ NKT 343 antagonized [Sar9]SP sulphone-evoked bronchoconstriction (70% reduction at 0.4 mg/kg, i.v.) in anaesthetized guinea-pigs[1].

IC 50

hNK1: 0.62 nM (IC50); hNK2: 0.52 μM (Ki); hNK3: 3.4 μM (Ki)

storage

Store at +4°C

1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide Preparation Products And Raw materials

Raw materials

Preparation Products

1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide Suppliers

Global Suppliers ( 29)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Jiangsu Hongmin Pharmaceutical Co., Ltd. 18221292452 fannieliu@glschina.com China 6798 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8137 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Suzhou Meishi Biotechnology Co., Ltd. 1173954148q meishipharma@126.com China 20027 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
VDM Biochemicals 64
EMMX Biotechnology LLC 60
TargetMol Chemicals Inc. 58
Jiangsu Hongmin Pharmaceutical Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
TargetMol Chemicals Inc. 58
Suzhou Meishi Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58

View Latest Price from 1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SDZ NKT 343 pictures 2026-04-20 SDZ NKT 343
180046-99-5
 $1520.00-2500.00 10g TargetMol Chemicals Inc.
  • SDZ NKT 343 pictures
  • SDZ NKT 343
    180046-99-5
  • $1520.00-2500.00
  • TargetMol Chemicals Inc.

180046-99-5 (1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide) Related Search:

Pyrrolidine-1-carboxylic acid amide 1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide Anti-Mouse NK1.1 Antibody (PK136) AZD2624 SENKTIDE
N-Acetyl-L-tryptophan

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SDZ NKT 343 L-Alaninamide, 1-[[(2-nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)- 1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide 180046-99-5 C33H33N5O5 Highly selective human tachykinin NK1 receptor antagonist .