6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid
![6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid Structure](CAS/GIF/133081-25-1.gif)
- CAS No.
- 133081-25-1
- Chemical Name:
- 6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid
- Synonyms
- 6-(2-(TERT-BUTOXYCARBONYL)HYDRAZINYL)NICOTINIC ACID;6-Boc-Hynic;4-HYDROXYETHANESULPHONICACID;6-Boc-hydrazinonicotinic acid;6-Boc-Hydrazynonicotinic acid;6-(2-Boc-hydrazino)nicotinic Acid;Butoxycarbonyl)hydrazinyl]nicotinic acid;6-(1-(tert-butoxycarbonyl)hydrazinyl)nicotinic acid;6-(2-(tert-butoxycarbonyl)hydrazineyl)nicotinic acid;6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid USP/EP/BP
- CBNumber:
- CB3947412
- Molecular Formula:
- C11H15N3O4
- Molecular Weight:
- 253.25
- MDL Number:
- MFCD03788696
- MOL File:
- 133081-25-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331-H315-H319 |
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405 |
6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-B943415-50MG | 6-Boc-Hynic | 133081-25-1 | 50mg | $55 | 2026-06-03 | Buy |
| TRC | TRC-B943415-500MG | 6-Boc-Hynic | 133081-25-1 | 500mg | $261 | 2026-06-03 | Buy |
| TRC | TRC-B943415-100MG | 6-Boc-Hynic | 133081-25-1 | 100mg | $71 | 2026-06-03 | Buy |
| Biosynth | FB151220 | 6-Boc-hydrazinonicotinicacid | 133081-25-1 | 100mg | $240 | 2026-06-04 | Buy |
| Biosynth | FB151220 | 6-Boc-hydrazinonicotinicacid | 133081-25-1 | 250mg | $385 | 2026-06-04 | Buy |
6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid Chemical Properties,Uses,Production
Uses
6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid is used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.
Synthesis
133081-24-0
24424-99-5
![6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid](/CAS/GIF/133081-25-1.gif)
133081-25-1
Di-tert-butyl dicarbonate (0.40 g, 1.82 mmol) was added to an N,N-dimethylformamide (DMF) solution of 6-hydrazinylpyridine-3-carboxylic acid (0.346 g, 1.82 mmol) and triethylamine (0.32 mL, 2.36 mmol). The reaction mixture was stirred at 25 °C for 1 h to become homogeneous, and stirring was continued for 16 h. The reaction was carried out under reduced pressure. After completion of the reaction, the solvent was removed under reduced pressure. The residue was diluted with a solvent mixture of ethyl acetate/methanol (4:1, v/v) and purified by silica gel column chromatography, using ethyl acetate as eluent, to afford 6-[2-(tert-butoxycarbonyl)hydrazinyl]nicotinic acid (4b) as a light yellow solid (0.44 g, 96% yield).IR (ATR, cm-1): 3353, 3227, 2975, 1719, 1593, 1472, 1372, 1256, 1014, 867, 794, 520. 1H NMR (DMSO-d6, δ): 12.584 (s, 1H), 8.59 (s, 1H), 7.97 (d, J = 9 Hz, 1H), 6.54 (d, J = 9 Hz, 1H). 13C NMR (DMSO-d6, δ): 166.6 , 155.7, 150.5, 138.5, 116.7, 79.3, 28.1, 14.0. MS (ESI-): [M-H]- m/z 252.00. MS (ESI+): [M+H]+ m/z 254.07. HRMS (ESI+): [M+H]+ m/z 254.1145 (calculated values) C11H16N3O4, 254.1141).
References
[1] Letters in Organic Chemistry, 2014, vol. 11, # 3, p. 208 - 214
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 16, p. 4764 - 4767
[3] Polish Journal of Chemistry, 2004, vol. 78, # 7, p. 951 - 959
[4] Journal of Labelled Compounds and Radiopharmaceuticals, 2018, vol. 61, # 2, p. 68 - 76
[5] Pharmazie, 2006, vol. 61, # 4, p. 269 - 273
6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. | 21-54820552 17702105771 | 188738128@qq.com | China | 300 | 66 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9886 | 55 |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9970 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Lastest Price from 6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid manufacturers
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2020-01-10 | 6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid
133081-25-1
|
$1.00 | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- 6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid
133081-25-1
- $1.00
- 99.0%
- Career Henan Chemical Co
