6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)-
- CAS No.
- 2411088-26-9
- Chemical Name:
- 6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)-
- Synonyms
- CC260;CC260,CC-260;6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)-
- CBNumber:
- CB39767233
- Molecular Formula:
- C24H29Cl2N5O2
- Molecular Weight:
- 490.43
- MDL Number:
- MFCD34474204
- MOL File:
- 2411088-26-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0181659 | CC260 99.45% | 2411088-26-9 | 5mg | $466 | 2026-06-04 | Buy |
| ChemScene | CS-0181659 | CC260 99.45% | 2411088-26-9 | 10mg | $737 | 2026-06-04 | Buy |
| ChemScene | CS-0181659 | CC260 99.45% | 2411088-26-9 | 25mg | $1473 | 2026-06-04 | Buy |
| ChemScene | CS-0181659 | CC260 99.45% | 2411088-26-9 | 50mg | $2362 | 2026-06-04 | Buy |
| ChemScene | CS-0181659 | CC260 99.45% | 2411088-26-9 | 100mg | $3792 | 2026-06-04 | Buy |
6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)- Chemical Properties, Uses, Production
Uses
CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1].
Biological Activity
CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1]. In cultured C2C12 myotubes, CC260 (20 μM) enhances Insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 but suppresses S6K phosphorylation (Thr-389) by mTORC1[1]. CC260 (2.5 μM, 5 μM, 10 μM, 20 μM) significantly increases phosphorylation of acetyl-CoA carboxylase (ACC) in a dose-dependent manner[1]. CC260 treatment reduces the ability of BT474 cells to survive serum starvation, which could be rescued by expressing the PI5P4Kβ refractory mutant[1]. In BT474 cells, CC260 treatment causes an increase in glycolytic ATP production[1].
References
[1]. Song Chen, et al. Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2002486118.
6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)- Preparation Products And Raw materials
Raw materials
Preparation Products
6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| Guangzhou Younan Technology Co., Ltd | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from 6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)- manufacturers
2411088-26-9 (6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)-) Related Search:
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