6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)-

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6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)- Suppliers list
Company Name: Guangzhou Younan Technology Co., Ltd  
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Company Name: TargetMol Chemicals Inc.  
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6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)- manufacturers

  • CC260
  • CC260 pictures
  • $1370.00
  • 2026-04-22
  • CAS:2411088-26-9
  • Purity:
  • Supply Ability: 10g
6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)- Basic information
Product Name:6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)-
Synonyms:6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)-;CC260;CC260,CC-260
CAS:2411088-26-9
MF:C24H29Cl2N5O2
MW:490.43
EINECS:
Product Categories:
Mol File:2411088-26-9.mol
6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)- Structure
6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)- Chemical Properties
Boiling point 696.6±65.0 °C(Predicted)
density 1.383±0.06 g/cm3(Predicted)
pka7.25±0.36(Predicted)
form Solid
color Off-white to gray
Safety Information
MSDS Information
6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)- Usage And Synthesis
UsesCC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1].
Biological ActivityCC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1]. In cultured C2C12 myotubes, CC260 (20 μM) enhances Insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 but suppresses S6K phosphorylation (Thr-389) by mTORC1[1]. CC260 (2.5 μM, 5 μM, 10 μM, 20 μM) significantly increases phosphorylation of acetyl-CoA carboxylase (ACC) in a dose-dependent manner[1]. CC260 treatment reduces the ability of BT474 cells to survive serum starvation, which could be rescued by expressing the PI5P4Kβ refractory mutant[1]. In BT474 cells, CC260 treatment causes an increase in glycolytic ATP production[1].
References[1]. Song Chen, et al. Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2002486118.
6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)- Preparation Products And Raw materials
Tag:6(5H)-Pteridinone, 8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-7,8-dihydro-5-methyl-, (7R)-(2411088-26-9) Related Product Information
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