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6-Hydroxy-chroman-4-one

6-Hydroxy-chroman-4-one Structure
6-Hydroxy-chroman-4-one structure
CAS No.
80096-64-6
Chemical Name:
6-Hydroxy-chroman-4-one
Synonyms
6-Hydroxy-4-chromanone;6-HYDROXY-CHROMAN-4-ONE;6-hydroxy-2,3-dihydrochroMen-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-6-hydroxy-
CBNumber:
CB41010905
Molecular Formula:
C9H8O3
Molecular Weight:
164.16
MDL Number:
MOL File:
80096-64-6.mol
Last updated:2026-05-28 01:19:59
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6-Hydroxy-chroman-4-one Properties

Melting point 129-131 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
Boiling point 372.4±42.0 °C(Predicted)
Density 1.343±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 9.58±0.20(Predicted)
Appearance Off-white to light yellow Solid
InChI InChI=1S/C9H8O3/c10-6-1-2-9-7(5-6)8(11)3-4-12-9/h1-2,5,10H,3-4H2
InChIKey HTKPIKIGEYFNBY-UHFFFAOYSA-N
SMILES C1OC2=CC=C(O)C=C2C(=O)C1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

6-Hydroxy-chroman-4-one price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FDA09664 6-Hydroxy-chroman-4-one 80096-64-6 2.5g $560.5 2026-06-04 Buy
Matrix Scientific 299354 6-Hydroxy-chroman-4-one 80096-64-6 250.00mg $49 2026-05-19 Buy
Matrix Scientific 299354 6-Hydroxy-chroman-4-one 80096-64-6 1.00g $176 2026-05-19 Buy
Matrix Scientific 299354 6-Hydroxy-chroman-4-one 80096-64-6 5.00g $541 2026-05-19 Buy
Synthonix H25459 6-Hydroxy-chroman-4-one 97% 80096-64-6 100mg $26 2026-05-06 Buy
Product number Packaging Price Buy
FDA09664 2.5g $560.5 Buy
299354 250.00mg $49 Buy
299354 1.00g $176 Buy
299354 5.00g $541 Buy
H25459 100mg $26 Buy

6-Hydroxy-chroman-4-one Chemical Properties, Uses, Production

Uses

6-Hydroxy-chroman-4-one is used in the preparation of novels parasite transmission blocking antimalarials targeting male gametes

Synthesis

6-Methoxy-4-chromanone

5802-17-5

6-Hydroxy-chroman-4-one

80096-64-6

(3) Preparation of 2,3-dihydro-6-hydroxychromen-4-one: 6-methoxychromen-dihydropyran-4-one (2.9 g, 0.0163 mol) was sequentially added to a mixed solution of glacial acetic acid (20 mL) and HBr (>40%, 20 mL), stirred and refluxed for 1 h. The reaction solution was then extracted with ethyl acetate. Upon completion of the reaction, the pH of the reaction solution was adjusted to 10-11 with KOH solution, and then the pH of the aqueous layer was adjusted to 2-3 with concentrated hydrochloric acid.Subsequently, the aqueous layer was extracted with ethyl acetate, and the organic layers were combined and dried with anhydrous Na2SO4. The dried organic layer was cooled and a black solid was precipitated. The solid was recrystallized with ethyl acetate to give 2.17 g of bright yellow crystals with a melting point of 142-144 °C and a yield of 81.2%.

References

[1] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 18, p. 2773 - 2778
[2] Patent: US5641789, 1997, A
[3] Patent: US2008/103307, 2008, A1. Location in patent: Page/Page column 17
[4] Patent: US5322847, 1994, A
[5] Patent: EP641792, 1995, A1

6-Hydroxy-chroman-4-one Preparation Products And Raw materials

Raw materials

6-Methoxy-4-chromanone

Preparation Products

6-Hydroxy-chroman-4-one Suppliers

Global Suppliers ( 56)
Supplier Tel Email Country ProdList Advantage
Shandong Xingzhi Biological Medicine Co. LTD 18366166027 xingzhi@xingzhipharm.com China 135 58
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
Shanghai Apichemical CO.,LTD 021-51370612; info@apichemical.com China 242 60
Shanghai Tombiopharma Chemical Co. Ltd. 13391076197 tombiopharma@163.com China 4986 55
LABTER PHARMATECH(BEIJING) CO.,LTD 010-56330744 18310155299 sales@labter.com.cn China 19999 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Huaian Hyperion pharmaceutical R&D Co.,Ltd. 18114966287 sales@hyperionpharm.com China 456 58
Supplier Advantage
Shandong Xingzhi Biological Medicine Co. LTD 58
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Guangzhou Isun Pharmaceutical Co., Ltd 55
Shanghai Apichemical CO.,LTD 60
Shanghai Tombiopharma Chemical Co. Ltd. 55
LABTER PHARMATECH(BEIJING) CO.,LTD 55
Amadis Chemical Company Limited 58
Huaian Hyperion pharmaceutical R&D Co.,Ltd. 58

6-Hydroxy-chroman-4-one Spectrum

6-Hydroxy-chroman-4-one(80096-64-6)1HNMR

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6-hydroxy-2,3-dihydrochroMen-4-one 4H-1-Benzopyran-4-one, 2,3-dihydro-6-hydroxy- 6-Hydroxy-4-chromanone 6-HYDROXY-CHROMAN-4-ONE 80096-64-6