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3-CHLORO-1-PHENYL-1-PROPANOL

3-CHLORO-1-PHENYL-1-PROPANOL structure

CAS No.: 18776-12-0

Chemical Name:: 3-CHLORO-1-PHENYL-1-PROPANOL

Synonyms: Fluoxetine impurity 5;3-CHLORO-1-PHENYLPROPANOL;rac 3-Chloro-1-phenylpropanol;α-(2-Chloroethyl)benzenemethanol;3-Chloro-1-phenyl-1-propanol >BenzeneMethanol, α-(2-chloroethyl)-;3-Chloro-1-phenylpropan-1-ol , 3-Chloro-1-phenyl-propanol

CBNumber:: CB41090893

Molecular Formula:: C9H11ClO

Molecular Weight:: 170.64

MDL Number:: MFCD09878800

MOL File:: 18776-12-0.mol

Last updated:2025-07-24 18:13:42

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3-CHLORO-1-PHENYL-1-PROPANOL Properties

Melting point	31.0 to 36.0 °C
Boiling point	116°C/4mmHg(lit.)
Density	1.1344 g/cm3
refractive index	1.54
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form	Solid
pka	13.92±0.20(Predicted)
color	White to Off-White
InChIKey	JZFUHAGLMZWKTF-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

HS Code

2906.29.6000

NFPA 704

	0
1		0

3-CHLORO-1-PHENYL-1-PROPANOL price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C2904	3-Chloro-1-phenyl-1-propanol >98.0%(GC)	18776-12-0	5g	$112	2025-07-31	Buy
TCI Chemical	C2904	3-Chloro-1-phenyl-1-propanol >98.0%(GC)	18776-12-0	25g	$391	2025-07-31	Buy
Usbiological	288653	rac 3-chloro-1-phenylpropanol	18776-12-0	25mg	$446	2021-12-16	Buy
TRC	C379650	rac3-Chloro-1-phenylpropanol	18776-12-0	250mg	$100	2021-12-16	Buy
ChemScene	CS-W019837	α-(2-Chloroethyl)benzenemethanol 99.60%	18776-12-0	500g	$655	2021-12-16	Buy

Product number	Packaging	Price	Buy
C2904	5g	$112	Buy
C2904	25g	$391	Buy
288653	25mg	$446	Buy
C379650	250mg	$100	Buy
CS-W019837	500g	$655	Buy

3-CHLORO-1-PHENYL-1-PROPANOL Chemical Properties,Uses,Production

Uses

An intermediate of racemic Atomoxetine.

Synthesis

936-59-4

18776-12-0

General procedure for the synthesis of 3-chloro-1-phenylpropan-1-one from 3-chloropropiophenone: 3-chloro-1-phenylpropan-1-one (7.80 g, 46.26 mmol) was dissolved in a solvent mixture of THF (35 mL) and EtOH (35 mL) at -10 °C and protected by nitrogen with stirring. Sodium borohydride (2.20 g, 48.83 mmol) was added in batches over 10 min. The reaction mixture was continued to be stirred at -5 °C for 10 min, followed by slow pouring into a stirring mixture of saturated aqueous ammonium chloride solution (85 mL) and ice (40 g). The mixture was extracted twice with ether, the organic phases were combined, dried and the solvent was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: cyclohexane/ethyl acetate, gradient from 100/0 to 95/5) to give 3-chloro-1-phenylpropanol (7.50 g, 95% yield) as a pale yellow oil. Nuclear magnetic resonance hydrogen spectrum (1H NMR, CDCl3) δ: 7.39 (d, 5H), 4.91-5.01 (m, 1H), 3.70-3.83 (m, 1H), 3.59 (s, 1H), 2.20-2.32 (m, 1H), 2.11 (d, 1H).

References

[1] Pharmaceutical Research, 2017, vol. 34, # 12, p. 2873 - 2890
[2] Biological and Pharmaceutical Bulletin, 2011, vol. 34, # 4, p. 538 - 544
[3] Patent: WO2016/67043, 2016, A1. Location in patent: Page/Page column 325
[4] Organic Process Research and Development, 2000, vol. 4, # 6, p. 513 - 519
[5] Journal of the Chemical Society, Perkin Transactions 1, 2000, # 11, p. 1767 - 1769

3-CHLORO-1-PHENYL-1-PROPANOL Preparation Products And Raw materials

Raw materials

Benzenemethanol, α-(2-chloroethyl)-, 1-nitrate 3-Chloropropiophenone Ethanol Tetrahydrofuran Sodium borohydride

Preparation Products

Cinnamyl chloride

3-CHLORO-1-PHENYL-1-PROPANOL Suppliers

Global( 196)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12151	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14360	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15144	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
HaBo Hong Kong Co., Limited.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Zhengzhou Alfa Chemical Co.,Ltd	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from 3-CHLORO-1-PHENYL-1-PROPANOL manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-13	3-Chloro-1-phenylpropanol 18776-12-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	3-Chloro-1-phenylpropanol 18776-12-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-09-05	3-CHLORO-1-PHENYL-1-PROPANOL 18776-12-0	US $1.80-3.60 / KG	1KG	99%	88KG	Career Henan Chemical Co

3-Chloro-1-phenylpropanol
18776-12-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

3-Chloro-1-phenylpropanol
18776-12-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

3-CHLORO-1-PHENYL-1-PROPANOL
18776-12-0
US $1.80-3.60 / KG
99%
Career Henan Chemical Co

18776-12-0(3-CHLORO-1-PHENYL-1-PROPANOL)Related Search:

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3-CHLORO-1-PHENYLPROPANOL rac 3-Chloro-1-phenylpropanol BenzeneMethanol, α-(2-chloroethyl)- Fluoxetine impurity 5 3-Chloro-1-phenyl-1-propanol > α-(2-Chloroethyl)benzenemethanol 3-Chloro-1-phenylpropan-1-ol , 3-Chloro-1-phenyl-propanol 18776-12-0 Aromatics Intermediates Benzene derivatives