2-Bromo-1-(4-dimethylamino-phenyl)-ethanone
- CAS No.
- 37904-72-6
- Chemical Name:
- 2-Bromo-1-(4-dimethylamino-phenyl)-ethanone
- Synonyms
- BUTTPARK 82\50-86;4-(Dimethylamino)phenacyl bromide;4-(Dimethylamino)phenacylbromide97%;2-BROMO-4'-DIMETHYLAMINOACETOPHENONE;4-(Dimethylamino)phenacyl bromide 97%;2-Bromo-1-(4-dimethylamino-phenyl)-ethanone;2-BroMo-1-[4-(diMethylaMino)phenyl]ethan-1-one;Ethanone, 2-bromo-1-[4-(dimethylamino)phenyl]-;2-Bromo-4'-(dimethylamino)acetophenone, 2-Bromo-1-[4-(dimethylamino)phenyl]ethan-1-one
- CBNumber:
- CB4113692
- Molecular Formula:
- C10H12BrNO
- Molecular Weight:
- 242.11
- MDL Number:
- MFCD06409221
- MOL File:
- 37904-72-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 89-92 |
|---|---|
| Boiling point | 330.2±22.0 °C(Predicted) |
| Density | 1.406±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Sparingly), DMSO (Slightly, Sonicated) |
| form | Solid |
| pka | 1.56±0.12(Predicted) |
| color | Yellow to Dark Yellow |
| InChI | 1S/C10H12BrNO/c1-12(2)9-5-3-8(4-6-9)10(13)7-11/h3-6H,7H2,1-2H3 |
| InChIKey | YWNKTZFJKMGVRP-UHFFFAOYSA-N |
| SMILES | CN(C)c1ccc(cc1)C(=O)CBr |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xi |
| WGK Germany | WGK 3 |
| Hazard Note | Harmful/Irritant/Keep Cold |
| HS Code | 2934309090 |
| Storage Class | 11 - Combustible Solids |
2-Bromo-1-(4-dimethylamino-phenyl)-ethanone price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS005074 | 2-bromo-1-(4-dimethylamino-phenyl)-ethanone AldrichCPR | 37904-72-6 | 100MG | $70.4 | 2026-04-30 | Buy |
| TRC | TRC-B691523-500MG | 2-Bromo-1-(4-dimethylaminophenyl)ethanone | 37904-72-6 | 500mg | $103 | 2026-06-03 | Buy |
| TRC | TRC-B691523-250MG | 2-Bromo-1-(4-dimethylaminophenyl)ethanone | 37904-72-6 | 250mg | $84 | 2026-06-03 | Buy |
| TRC | TRC-B691523-100MG | 2-Bromo-1-(4-dimethylaminophenyl)ethanone | 37904-72-6 | 100mg | $66 | 2026-06-03 | Buy |
| Apolloscientific | OR3530 | 4-(Dimethylamino)phenacyl bromide 95% | 37904-72-6 | 250mg | $28 | 2026-06-04 | Buy |
2-Bromo-1-(4-dimethylamino-phenyl)-ethanone Chemical Properties, Uses, Production
Uses
2-Bromo-1-(4-dimethylaminophenyl)ethanone can be used as potential biomarkers for respiratory illness.
Synthesis
![Ethanone, 2,2-dibromo-1-[4-(dimethylamino)phenyl]-](/CAS/GIF/210832-81-8.gif)
210832-81-8
37904-72-6
The general procedure for the synthesis of 2-bromo-1-(4-(dimethylamino)phenyl)ethanone from the compound (CAS: 210832-81-8) was as follows: 5.1 g (1 eq.) of the raw material was dissolved in 30 mL of THF, and cooled to 0°C. Subsequently, a mixed solution consisting of diethyl phosphite (2.04 mL, 1 eq.) and triethylamine (2.4 mL, 1.1 eq.) in 12 mL of THF was added slowly and dropwise. The reaction mixture was stirred at room temperature for 6 hours. Upon completion of the reaction, the solvent was removed by rotary evaporation and the residue was poured into 200 mL of ice water. The resulting precipitate was collected by filtration, washed with water and dried under vacuum to give the green solid product 3 in 89% yield. The structure of the product was confirmed by nuclear magnetic resonance hydrogen (1H NMR, CDCl3) and carbon (13C NMR, CDCl3) spectra: 1H NMR (CDCl3) δ 2.97 (s, 6H, 2×CH3), 4.45 (s, 2H, CH2), 6.57 (d, 2H, J = 9.0 Hz, 2×CHAr), 7.72 (d, 2H, CHAr); 13C NMR (CDCl3) δ 31.3 (1C, CH2), 40.4 (2C, CH3), 111.1 (2C, CHAr), 121.8 (1C, Cq), 131.6 (2C, CHAr), 154.1 (1C, Cq), 189.7 (1C, Cq).
References
[1] Tetrahedron Letters, 1998, vol. 39, # 28, p. 4987 - 4990
[2] Patent: US2007/258887, 2007, A1. Location in patent: Page/Page column 28; 39-40
[3] Chemical Communications, 2016, vol. 52, # 90, p. 13277 - 13280
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 2966 - 2968
[5] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 7, p. 596 - 600
2-Bromo-1-(4-dimethylamino-phenyl)-ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Shanghai Boyners Pharm-Tech Co., Ltd. | 13817873692 | mkt@boynerspharm.com | China | 1707 | 55 |
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