3-Methyl-quinoxaline-2-carboxylic Acid
- CAS No.
- 74003-63-7
- Chemical Name:
- 3-Methyl-quinoxaline-2-carboxylic Acid
- Synonyms
- MQCA;3-Methyl-2-quinoxalinecarboxylic Acid;RCG-210;RCG-210, MQCA;MQCA Standard;Valine Impurity 62;MQCA Solution, 1000ppm;Carbadox Impurity 1 (MQCA);2-Quinoxalinecarboxylic acid, 3-methyl-;3-Methylquinoxaline-2-carboxylic Acid solution
- CBNumber:
- CB41175765
- Molecular Formula:
- C10H8N2O2
- Molecular Weight:
- 188.18
- MDL Number:
- MFCD03840415
- MOL File:
- 74003-63-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 168-170°C |
|---|---|
| Boiling point | 347.1±37.0 °C(Predicted) |
| Density | 1.355±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMF: 25 mg/mL; DMSO: 30 mg/mL; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/mL; Ethanol: 25 mg/mL |
| form | Solid |
| pka | 2.37±0.30(Predicted) |
| color | Brown to dark brown |
| Major Application |
forensics and toxicology pharmaceutical (small molecule) |
| InChI | 1S/C10H8N2O2/c1-6-9(10(13)14)12-8-5-3-2-4-7(8)11-6/h2-5H,1H3,(H,13,14) |
| InChIKey | BJPNADFNSANIPF-UHFFFAOYSA-N |
| SMILES | Cc1nc2ccccc2nc1C(O)=O |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P301+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36/37 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933998090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Methyl-quinoxaline-2-carboxylic Acid price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 32862 | 3-Methyl-2-quinoxalinecarboxylic acid VETRANAL | 74003-63-7 | 50mg | $958 | 2026-04-30 | Buy |
| Cayman Chemical | 25664 | 3-Methylquinoxaline-2-carboxylic Acid ≥98% | 74003-63-7 | 5mg | $98 | 2026-04-30 | Buy |
| Cayman Chemical | 25664 | 3-Methylquinoxaline-2-carboxylic Acid ≥98% | 74003-63-7 | 10mg | $185 | 2026-04-30 | Buy |
| Cayman Chemical | 25664 | 3-Methylquinoxaline-2-carboxylic Acid ≥98% | 74003-63-7 | 50mg | $435 | 2026-04-30 | Buy |
| Cayman Chemical | 25664 | 3-Methylquinoxaline-2-carboxylic Acid ≥98% | 74003-63-7 | 100mg | $819 | 2026-04-30 | Buy |
3-Methyl-quinoxaline-2-carboxylic Acid Chemical Properties, Uses, Production
Description
3-Methylquinoxaline-2-carboxylic acid (MQCA) is a major metabolite of olaquindox, an antibiotic and swine growth regulator. It induces cell cycle arrest at the S phase and is toxic to Chang liver cells in a concentration- and time-dependent manner. MQCA has been used as a marker of olaquindox use in livestock applications.
Chemical Properties
Yellow Solid
Uses
A metabolite of Carbadox and Olaquindox
Uses
A Carbadox and Olaquindox metabolite.
Synthesis
61522-54-1
74003-63-7
Methyl 3-methylquinoxaline-2-carboxylate (0.20 g, 0.99 mmol) was used as a raw material and dissolved in a solvent mixture of methanol (8 mL) and 2N sodium hydroxide solution (2 mL). The reaction mixture was stirred at room temperature for 30 min and then concentrated to about 1/3 of the original volume by rotary evaporator.Subsequently, the pH was adjusted to acidic with 1N hydrochloric acid solution and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline, and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated by rotary evaporation to obtain a solid product, which was finally dried under high vacuum to give 3-methylquinoxaline-2-carboxylic acid (0.16 g, 87% yield).
References
[1] Patent: US2005/43292, 2005, A1. Location in patent: Page/Page column 12
[2] Patent: CN108440425, 2018, A. Location in patent: Paragraph 0084-0086
3-Methyl-quinoxaline-2-carboxylic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing SynTitan Pharmaceutical Co., Ltd. | 25-57027686 17372956142 | li_lan@syntitan.com | China | 8000 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Chengdu YouSuo Biotechnology Limited | 13693449011 | 83948782@qq.com | China | 92 | 50 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4508 | 55 |
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