Zanoterone
- CAS No.
- 107000-34-0
- Chemical Name:
- Zanoterone
- Synonyms
- Win-49596;Zanoterone;17-Ethynyl-1'-methylsulfonyl-1'H-5α-androstano[3,2-c]pyrazole-17β-ol;1'H-Pregn-20-yno[3,2-c]pyrazol-17-ol, 1'-(methylsulfonyl)-, (5α,17α)-;17-Ethynyl-1'-(methylsulfonyl)-1'H-5α-androstano[3,2-c]pyrazole-17β-ol;17α-Ethynyl-1'-methylsulfonyl-1'H-5α-androsta-2-eno[3,2-c]pyrazole-17-ol
- CBNumber:
- CB41180091
- Molecular Formula:
- C23H32N2O3S
- Molecular Weight:
- 416.58
- MDL Number:
- MOL File:
- 107000-34-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 200-202 °C(Solv: acetonitrile (75-05-8)) |
|---|---|
| Boiling point | 564.0±60.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| pka | 13.12±0.60(Predicted) |
| FDA UNII | XQ5V1W49JG |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
Zanoterone price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0025059 | Zanoterone | 107000-34-0 | 1mg | $396 | 2026-06-04 | Buy |
| ChemScene | CS-0025059 | Zanoterone | 107000-34-0 | 5mg | $1004 | 2026-06-04 | Buy |
| ChemScene | CS-0025059 | Zanoterone | 107000-34-0 | 10mg | $1454 | 2026-06-04 | Buy |
| aablocks | AA008ZAI | Zanoterone | 107000-34-0 | 1mg | $242 | 2026-05-28 | Buy |
| aablocks | AA008ZAI | Zanoterone | 107000-34-0 | 5mg | $589 | 2026-05-28 | Buy |
Zanoterone Chemical Properties, Uses, Production
Originator
Zanoterone ,Sterling Drug (Sanofi-Aventis)
Uses
Anti-androgen.
Definition
ChEBI: Zanoterone is a steroid. It derives from a hydride of an estrane.
Manufacturing Process
1). A solution of methanesulfonylhydrazide (0.0303 mole) in tetrahydrofuran
(70 ml, 30 ml for rinsing) was added with stirring to a solution of
(2α,5α,17α)-2-(diethoxymethyl)-17-[(trifluororacetyl)oxy]pregn-20-yn-3-one
(0.025 mole) in tetrahydrofuran (190 ml). The mixture was allowed to stand
for 3 days at room temperature, heated under reflux for 4 h and evaporated.
The residue was purified by crystallization and recrystallization from methanol,
affording (5α,17α)-1'-(methylsulfonyl)-1'H-pregn-20-yno[3,2-c]pyrazol-17-ol
trifluoroacetate (ester), 69% yield, MP: 166°-168°C.
The above ester (10.24 g, 0.0200 mole) in 100 ml of a solution prepared from
chloroform (210 ml), ethanol (100 ml) and concentrated aqueous ammonia
(10 ml) was allowed to stand at room temperature for 2 h, diluted with
chloroform (250 ml), and washed with dilute hydrochloric acid (2 N, 250 ml).
The chloroform layer was dried and removed of chloroform under vacuum. A
solution of the residue in dichloromethane (95 ml) and ether (5 ml) was
passed through silica gel (50 g) using more dichloromethane-ether (19:1, 600
ml). Evaporation of the solvent and recrystallization of the residue from
acetonitrile afforded (5α,17α)-1'-(methylsulfonyl)-1'H-pregn-20-yno[3,2-
c]pyrazol-17-ol (7.07 g, 85% yield, MP: 202°-203°C). It may be also made
another way.
2). A solution of methanesulfonylhydrazide (82.5 g, 0.75 mole) in acetic acid
(100 ml) was added with stirring over 5 min to a mixture of (5α,17α)-2-
(acetoxymethylene)-17-hydroxypregn-20-yn-3-one (197 g, 0.51 mole) and
acetic acid (1 L). The mixture was stirred for 1 h at room temperature,
forming a deep yellow solution, which was poured with vigorous stirring into
ice-water (6 L). The resulting solid was collected by filtration, washed twice
with water (500 ml each time), pressed dry, washed twice again with water
(500 ml each time), dried (245 g), recrystallized, first from acetonitrile (2.5
volumes) and then from methanol (6.6 volumes), dried, ground, and redried,
affording (5α,17α)-1'-(methylsulfonyl)-1'-H-pregn-20-yno[3,2-c]pyrazol-17-ol
(137.8 g, 65% yield, MP: 194°-196°C).
Therapeutic Function
Antiandrogen
Zanoterone Preparation Products And Raw materials
Zanoterone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Supplier | Advantage |
|---|---|
| LGM Pharma | 70 |
| TargetMol Chemicals Inc. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 58 |
View Latest Price from Zanoterone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Zanoterone
107000-34-0
|
$191.00-687.00 | 99.96% | 10g | TargetMol Chemicals Inc. |
-
- Zanoterone
107000-34-0
- $191.00-687.00
- 99.96%
- TargetMol Chemicals Inc.
