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ChemicalBook >> CAS DataBase List >>2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]-

2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]-

2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- Structure
2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- structure
CAS No.
2769753-10-6
Chemical Name:
2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]-
Synonyms
TAE648;5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(4-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine;2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]-
CBNumber:
CB412106974
Molecular Formula:
C23H27ClN6O2S
Molecular Weight:
487.02
MDL Number:
MOL File:
2769753-10-6.mol
MSDS File:
SDS
Last updated:2025-04-18 09:52:13
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2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- Properties

Boiling point 717.9±70.0 °C(Predicted)
Density 1.340±0.06 g/cm3(Predicted)
pka 8.98±0.10(Predicted)

2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-1240806 TAE648 99.50% 2769753-10-6 5mg $244 2026-06-04 Buy
ChemScene CS-1240806 TAE648 99.50% 2769753-10-6 10mg $390 2026-06-04 Buy
ChemScene CS-1240806 TAE648 99.50% 2769753-10-6 25mg $780 2026-06-04 Buy
ChemScene CS-1240806 TAE648 99.50% 2769753-10-6 50mg $1246 2026-06-04 Buy
ChemScene CS-1240806 TAE648 99.50% 2769753-10-6 100mg $2004 2026-06-04 Buy
Product number Packaging Price Buy
CS-1240806 5mg $244 Buy
CS-1240806 10mg $390 Buy
CS-1240806 25mg $780 Buy
CS-1240806 50mg $1246 Buy
CS-1240806 100mg $2004 Buy

2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- Chemical Properties, Uses, Production

Uses

TAE648 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). TAE648 can be used for synthesis PROTAC SK-3-91 (HY-137341)[1].

References

[1] Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020;183(6):1714-1731.e10. DOI:10.1016/j.cell.2020.10.038
[2] Cha HJ, et al. Selective FGFR inhibitor BGJ398 inhibits phosphorylation of AKT and STAT3 and induces cytotoxicity in sphere-cultured ovarian cancer cells. Int J Oncol. 2017 Apr;50(4):1279-1288. DOI:10.3892/ijo.2017.3913

2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- Suppliers

Global Suppliers ( 2)
Supplier Tel Email Country ProdList Advantage
Aikon International Limited 025-58859352 18651614124 2881516338@qq.com China 9968 58
TargetMol 400-821-0310 15002144251 xuexiang.shao@tsbiochem.com China 29128 58
Supplier Advantage
Aikon International Limited 58
TargetMol 58

2769753-10-6 (2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]-) Related Search:

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2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(4-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine TAE648 2769753-10-6