N-Pyrazinylthiourea
- CAS No.
- 31437-05-5
- Chemical Name:
- N-Pyrazinylthiourea
- Synonyms
- -Pyrazinylthiourea;N-Pyrazinylthiourea;Thiourea, N-2-pyrazinyl-;1-(Pyrazin-2-Yl)Thiourea
- CBNumber:
- CB41249622
- Molecular Formula:
- C5H6N4S
- Molecular Weight:
- 154.19
- MDL Number:
- MOL File:
- 31437-05-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P501-P270-P264-P301+P310+P330-P405 |
N-Pyrazinylthiourea price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS49980 | 1-(Pyrazin-2-yl)thiourea 97% | 31437-05-5 | 1g | $25 | 2026-06-04 | Buy |
| Activate Scientific | AS49980 | 1-(Pyrazin-2-yl)thiourea 97% | 31437-05-5 | 5g | $70 | 2026-06-04 | Buy |
| Activate Scientific | AS49980 | 1-(Pyrazin-2-yl)thiourea 97% | 31437-05-5 | 25g | $321 | 2026-06-04 | Buy |
| Matrix Scientific | 208419 | Pyrazin-2-yl-thiourea | 31437-05-5 | 1.00g | $216 | 2026-05-18 | Buy |
| aablocks | AA007JCM | 1-(Pyrazin-2-yl)thiourea 97% | 31437-05-5 | 1g | $20 | 2026-05-28 | Buy |
N-Pyrazinylthiourea Chemical Properties, Uses, Production
Synthesis
31437-04-4
31437-05-5
Ammonium thiocyanate (17.8 g, 0.234 mol) was dissolved in anhydrous acetone (200 mL) under nitrogen protection and cooled to 0°C. Benzoyl chloride (30 g, 0.213 mol) was slowly added dropwise over 15 min, keeping the reaction temperature at 0 °C. After the dropwise addition was completed, the reaction mixture was warmed to room temperature and stirring was continued for 30 min, followed by filtration. To the filtrate, 2-aminopyrazine (16.2 g, 0.17 mol) was added and the reaction was stirred at room temperature for 3 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was diluted with water to precipitate a solid. The solid was collected by filtration and dried to give N-[(pyrazin-2-ylamino)thiocarbonyl]benzamide (33 g, 76% yield).TLC conditions: chloroform/methanol (9:1), Rf=0.5.N-[(pyrazin-2-ylamino)thiocarbonyl]benzamide (25 g, 0.096 mol) was dissolved in 10% NaOH solution (200 mL) and stirred at 80°C for 20 min. and stirred at 80 °C for 20 min. The reaction mixture was cooled and the solvent was removed under reduced pressure. The residue was acidified to pH=1 with 2 M HCl and subsequently alkalized with ammonium hydroxide. The precipitated solid was collected by filtration and dried by suction to give 1-(pyrazin-2-yl)thiourea (12 g, 80% yield). Product characterization: 1H NMR (DMSO-d6, 300 MHz): δ 8.24 (br s, 2H), 8.54 (s, 1H), 9.10 (m, 1H), 9.95 (m, 1H), 10.66 (br s, 1H). Mass Spectrometry (ESI): m/z 154.9 [M+H]+. HPLC (Method B): retention time 3.47 min (purity 98.23%). TLC: Chloroform/methanol (9:1), Rf=0.25. Melting point: 234-235°C.
References
[1] Patent: WO2006/125805, 2006, A1. Location in patent: Page/Page column 50-51
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 16, p. 2641 - 2645
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 12, p. 3081 - 3085
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 14, p. 3706 - 3712
[5] Tetrahedron Letters, 2018, vol. 59, # 17, p. 1623 - 1626
N-Pyrazinylthiourea Preparation Products And Raw materials
Raw materials
Preparation Products
N-Pyrazinylthiourea Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing FYF Chemicals Co., Ltd | 010-57903446 15869909019 | 168931144@qq.com | China | 2876 | 58 |
| Shanghai Tombiopharma Chemical Co. Ltd. | 13391076197 | tombiopharma@163.com | China | 4986 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Pingguo Pharmaceutical Co., Ltd. | 021-20432229 | 2412110556@qq.com | China | 6016 | 55 |
| Shanghai XunTang Chemical Technology Co., Ltd. | 15900811974 | 546264981@qq.com | China | 97 | 58 |
| Suzhou chems bio-tech.co.,Ltd. | 0512-67903504 13814824891;13814824891 | 604360797@qq.com | China | 409 | 58 |
| Suzhou Ran enzyme Biotechnology Co., Ltd. | 0512-0512-62793604 18015430729 | 116667374@qq.com | China | 132 | 58 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Guangdong wengjiang Chemical Reagent Co., Ltd. | 0751-2815688 13927872512 | 3007421951@qq.com | China | 9996 | 58 |
View Latest Price from N-Pyrazinylthiourea manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-07-21 | N-Pyrazinylthiourea
31437-05-5
|
$1.00 | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-09-11 | N-Pyrazinylthiourea
31437-05-5
|
$1.00 | 1KG | 98 | 200kg | Career Henan Chemical Co |
-
- N-Pyrazinylthiourea
31437-05-5
- $1.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- N-Pyrazinylthiourea
31437-05-5
- $1.00
- 98
- Career Henan Chemical Co
