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ChemicalBook >> CAS DataBase List >>2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)-

2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)-

2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- Structure
2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- structure
CAS No.
2366264-18-6
Chemical Name:
2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)-
Synonyms
JNK3 inhibitor-2;2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)-
CBNumber:
CB412697867
Molecular Formula:
C20H14N2O2
Molecular Weight:
314.34
MDL Number:
MOL File:
2366264-18-6.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
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2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- Properties

Boiling point 557.4±50.0 °C(Predicted)
Density 1.334±0.06 g/cm3(Predicted)
pka 15.06±0.20(Predicted)

2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- Chemical Properties, Uses, Production

Uses

JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC50 values of >100, >100, 0.25 μM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition[1].

IC 50

JNK1: >100 μM (IC50); JNK2: >100 μM (IC50); JNK3: 0.25 μM (IC50)

References

[1] Dou X, et al. Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors. Eur J Med Chem. 2020 Sep 1;201:112445. DOI:10.1016/j.ejmech.2020.112445

2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- Preparation Products And Raw materials

Raw materials

Preparation Products

2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- Suppliers

Global Suppliers ( 5)
Supplier Tel Email Country ProdList Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9780 55
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 5000 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. hanfangpharma@126.com 15165037910 hanfangpharma@126.com China 25800 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Jinan Jiuli Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. 58
TargetMol Chemicals Inc. 58

View Latest Price from 2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JNK3 inhibitor-2 pictures 2026-07-27 JNK3 inhibitor-2
2366264-18-6
 $1520.00-2500.00 10g TargetMol Chemicals Inc.

2366264-18-6 (2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)-) Related Search:

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2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- JNK3 inhibitor-2 2366264-18-6