Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate
- CAS No.
- 70254-52-3
- Chemical Name:
- Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate
- Synonyms
- ETHYL 2,4-DIHYDROXY-6-METHYLNICOTINATE;BUTTPARK 153\57-17;Ethyl2,4-dihydroxy-;Quinidine Impurity 19;Ethy 2,4-Dihydroxy-6-Methylnicotinate;Ethyl2,4-Dihydroxy-6-methylnicotinate>Ethyl 2,4-dihydroxy-6-methylnicotinate 97%;ETHYL 2,4-DIHYDROXY-6-METHYL-3-PYRIDINECARBONATE;Ethyl 2,4-dihydrOxy-6-methy3-pyridinecarBOxylate;2,4-dihydroxy-6-Methyl-nicotinic acid ethyl ester
- CBNumber:
- CB4128832
- Molecular Formula:
- C9H11NO4
- Molecular Weight:
- 197.19
- MDL Number:
- MFCD02929397
- MOL File:
- 70254-52-3.mol
- MSDS File:
- SDS
| Melting point | 205 °C |
|---|---|
| Boiling point | 446.0±40.0 °C(Predicted) |
| Density | 1.312±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 8.08±0.28(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C9H11NO4/c1-3-14-9(13)7-6(11)4-5(2)10-8(7)12/h4H,3H2,1-2H3,(H2,10,11,12) |
| InChIKey | CMCZAWPDHHYFPU-UHFFFAOYSA-N |
| SMILES | C1(O)=NC(C)=CC(O)=C1C(OCC)=O |
| CAS DataBase Reference | 70254-52-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E0869 | Ethyl 2,4-Dihydroxy-6-methylnicotinate >98.0%(GC)(T) | 70254-52-3 | 1g | $144 | 2026-04-30 | Buy |
| TCI Chemical | E0869 | Ethyl 2,4-Dihydroxy-6-methylnicotinate >98.0%(GC)(T) | 70254-52-3 | 5g | $528 | 2026-04-30 | Buy |
| Apolloscientific | OR5584 | Ethyl 2,4-dihydroxy-6-methylnicotinate 97% | 70254-52-3 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR5584 | Ethyl 2,4-dihydroxy-6-methylnicotinate 97% | 70254-52-3 | 5g | $28 | 2026-06-04 | Buy |
| Apolloscientific | OR5584 | Ethyl 2,4-dihydroxy-6-methylnicotinate 97% | 70254-52-3 | 10g | $41 | 2026-06-04 | Buy |
Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate Chemical Properties, Uses, Production
Uses
Ethyl 2,4-Dihydroxy-6-methylnicotinate, is a building block used for various chemical compounds. It is used for the synthesis of analogs of Lucanthone, having antitumor and bactericidal properties.
Synthesis
626-34-6
105-53-3
10350-10-4
The general procedure for the synthesis of ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate from ethyl 3-aminocrotonate and diethyl malonate was as follows: ethyl 3-aminocrotonate (100 g, 0.7752 mol) was added to a reactor, followed by the addition of sodium ethoxide (65 g, 0.9559 mol) and anhydrous ethanol (240 g). The reaction system was slowly heated to 80-90 °C, kept at reflux, and the reaction was stirred at this temperature for 24 hours. Upon completion of the reaction, the system was cooled to 50-60 °C and concentrated under reduced pressure to remove about 100 g of ethanol. The concentrated solution was slowly poured into 1000 ml of water, 10 g of basic activated carbon was added, stirred for 1 hour and filtered. The filtrate was cooled to below 0°C and the pH was adjusted to 2 to 3 with ammonium chloride, at which time a large amount of solid precipitated, and the solid was collected by filtration. The resulting solid was dried at 50 to 60°C to give white needle-like crystals of ethyl 2,4-dihydroxy-6-methyl-nicotinate in a yield of 125 g (yield = 81.85%, HPLC purity = 99.5%).
References
[1] Patent: CN106279011, 2017, A. Location in patent: Paragraph 0021; 0022
[2] Chemische Berichte, 1898, vol. 31, p. 766,769
[3] Chemische Berichte, 1898, vol. 31, p. 765
Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Synteam Biochem CO.,ltd | +86-021-58380978 13482386415 | info@systeambc.com | China | 897 | 50 |
| Aobolihui | 0917-18691729 18691729963 | 2553382659@qq.com | China | 4726 | 58 |
| Chengdu Zhongde Jihua Pharmaceutical Technology Co., Ltd | 15928014948; 15928014948 | 3438599507@qq.com | China | 97 | 58 |
| Hangzhou Aolishen Chemical Co., Ltd. | 571-81727727 15267468089 | Frank.luo@aolisenchemical.com | China | 473 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
View Latest Price from Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate
70254-52-3
|
$5.00 | 1kg | ≥99% | 20mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-08-20 | Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate
70254-52-3
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-04-04 | Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate
70254-52-3
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate
70254-52-3
- $5.00
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate
70254-52-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate
70254-52-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
