verrucarin J
- CAS No.
- 4643-58-7
- Chemical Name:
- verrucarin J
- Synonyms
- Verrucrin J;verrucarin J;Verrucarin J DISCONTINUED;Verrucarin A, 2',3'-didehydro-2'-deoxy-, (2'E)-
- CBNumber:
- CB41313695
- Molecular Formula:
- C27H32O8
- Molecular Weight:
- 484.54
- MDL Number:
- MOL File:
- 4643-58-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 735.4±60.0 °C(Predicted) |
|---|---|
| alpha | D19 +54° (benzene); D22 +20 ± 2° (c = 1.011 in chloroform) |
| Density | 1.29±0.1 g/cm3(Predicted) |
| solubility |
Dichloromethane: Soluble DMSO: Soluble Ethanol: Soluble Methanol: Soluble |
| form | powder |
| color | White |
| FDA UNII | 62UBU5Q68G |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H310+H330 |
| Precautionary statements | P260-P262-P361+P364 |
| RIDADR | 3172 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 2941900000 |
verrucarin J price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 40815 | Verrucarin J ≥70% | 4643-58-7 | 1mg | $501 | 2026-04-30 | Buy |
| ChemScene | CS-0255891 | Verrucarin J | 4643-58-7 | 1mg | $650 | 2026-06-04 | Buy |
| Apolloscientific | BIV1007 | Verrucarin J | 4643-58-7 | 100μg | $67 | 2026-06-04 | Buy |
| Apolloscientific | BIV1007 | Verrucarin J | 4643-58-7 | 1mg | $441 | 2026-06-04 | Buy |
| Apolloscientific | BIV1007 | Verrucarin J | 4643-58-7 | 5mg | $1649 | 2026-06-04 | Buy |
verrucarin J Chemical Properties, Uses, Production
Uses
Verrucarin J can be used in biological study of characteristics of toxigenic properties of Myrothecium cinctum and Myrothecium commune.
Definition
ChEBI: Verrucarin j is a trichothecene.
in vivo
Verrucarin J (0.5mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model[2].
Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent anticancer drug and suppresses tumor growth and metastasis[5].
| Animal Model: | 6-8 weeks old BALB/c athymic nude mice (nu/nu) with pCMV/HCT 116 and AKT/HCT 116 xenografts[2] |
| Dosage: | 0.5mg/kg body weight |
| Administration: | i.p. for 4 weeks |
| Result: | Reduced the expression of prosurvival markers pAKT, Notch1, p65, and Ki67 in all tumors. |
| Animal Model: | Female nude nu/nu (5 to 6 weeks old) mice with A2780 xenografts[5] |
| Dosage: | 0.1, 0.5, 2.0 mg/kg (vehicle: 10% DMSO, 90% glyceryl trioctanoate) |
| Administration: | i.p. for three weeks after 10 days of injection of A2780 cells |
| Result: | Reduced tumor weight (32% lower compared to control), and reduced visible metastasis in 0.1 mg/kg. Showed a significant reduction in visible peritoneal tumors (61% lower compared to control group) and highly reduced visible metastasis in 0.5 mg/kg. Reduced ovarian tumor weight by 71% compared to vehicle in 0.5 mg/kg. In lethal dose 2 mg/kg, mice sick with a swollen belly, body fluid and subsequently died within 3 treatments. |
References
[1] MINH VAN NGUYEN. Curvicollide D, a new modified γ-lactone from the culture broth of Albifimbria verrucaria and its antifungal activity against plant pathogenic fungi[J]. Journal of Antibiotics, 2022, 75 9: 514-518. DOI: 10.1038/s41429-022-00541-7
[2] KAREN UDOH. Targeting of Lung Cancer Stem Cell Self-Renewal Pathway by a Small Molecule Verrucarin J.[J]. Stem Cell Reviews and Reports, 2019, 15 4: 601-611. DOI: 10.1007/s12015-019-09874-7
[3] DEEKSHA PAL. Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer.[J]. ACS Biomaterials Science & Engineering, 2018: 798. DOI: 10.1038/s41419-018-0810-8
verrucarin J Preparation Products And Raw materials
Raw materials
Preparation Products
verrucarin J Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Wuhan SynBioLily Biotechnology Co.,Ltd. | 18971458902 | yangsong@synbiolily.com | China | 482 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| Wuhan SynBioLily Biotechnology Co.,Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from verrucarin J manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Verrucarin J
4643-58-7
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- Verrucarin J
4643-58-7
- $1520.00-2500.00
- TargetMol Chemicals Inc.
