ChemicalBook >> CAS DataBase List >>1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]-

1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]-

1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]- structure

CAS No.: 2815263-05-7

Chemical Name:: 1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]-

Synonyms: 1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]-

CBNumber:: CB413140348

Molecular Formula:: C29H27N5O

Molecular Weight:: 461.56

MDL Number:

MOL File:: 2815263-05-7.mol

MSDS File:: SDS

Last updated:2026-07-27 17:00:41

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1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]- Properties

Boiling point	693.6±65.0 °C(Predicted)
Density	1.251±0.06 g/cm3(Predicted)
pka	16.13±0.30(Predicted)
form	Solid
color	Light yellow to yellow

1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0567362	GPR84 antagonist 3 98.32%	2815263-05-7	5mg	$325	2026-06-04	Buy
ChemScene	CS-0567362	GPR84 antagonist 3 98.32%	2815263-05-7	10mg	$520	2026-06-04	Buy
ChemScene	CS-0567362	GPR84 antagonist 3 98.32%	2815263-05-7	25mg	$1029	2026-06-04	Buy
ChemScene	CS-0567362	GPR84 antagonist 3 98.32%	2815263-05-7	50mg	$1571	2026-06-04	Buy
ChemScene	CS-0567362	GPR84 antagonist 3 98.32%	2815263-05-7	100mg	$2437	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0567362	5mg	$325	Buy
CS-0567362	10mg	$520	Buy
CS-0567362	25mg	$1029	Buy
CS-0567362	50mg	$1571	Buy
CS-0567362	100mg	$2437	Buy

1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]- Chemical Properties, Uses, Production

Uses

GPR84 antagonist 3 (compound 42) is a potent GPR84 (G-protein-coupled receptor 84) antagonist. GPR84 antagonist 3 inhibits GTPγS, with a pIC50 of 8.28. GPR84 antagonist 3 has a favorable pharmacokinetic profile suitable[1].

in vivo

GPR84 antagonist 3 (compound 42) (1 mg/kg (IV), 10 mg/kg (Orally); once) has a good elimination half-life (2.51 h), moderate rate of clearance, and bioavailability^[1].

Animal Model:

Male C57BL/6J mice (n = 3)^[1]

Dosage:

1 mg/kg (IV), 10 mg/kg (Orally)

Administration:

IV, Orally; once (Pharmacokinetic Analysis)

Result:

Pharmacokinetic Parameters of GPR84 antagonist 3 in Male C57BL/6J mice^[1].

	IV (1 mg/kg)	PO (10 mg/kg)
half-life (h)	2.51 ± 6.55
CL (mL/min/kg)	38.9 ± 13.9
Vss (L/kg)	7.24 ± 9.2
C₀ (ng/mL)	394 ± 19.1
AUCall (ng/mL·h)	420 ± 12.5	1590 ± 18.7
T_max (h)		1
C_max (ng/mL)		402 ± 31.8
F (%)		36.8 ± 18.7

References

[1] Mahindra A, et al. Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists. J Med Chem. 2022 Aug 10. DOI:10.1021/acs.jmedchem.2c00804

1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]- Suppliers

Global Suppliers ( 3)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11963	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58

Supplier	Advantage
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

View Latest Price from 1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	GPR84 antagonist 3 2815263-05-7	$3070.00-4310.00			10g	TargetMol Chemicals Inc.

GPR84 antagonist 3
2815263-05-7
$3070.00-4310.00
TargetMol Chemicals Inc.

2815263-05-7 (1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]-) Related Search:

1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]- GPR84 antagonist 1 NA 3,3′-Methylenebis[5,7-difluoro-1H-indole] TUG-2099

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1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]- 2815263-05-7