ETHYL TRIMETHYLACETOPYRUVATE
- CAS No.
- 13395-36-3
- Chemical Name:
- ETHYL TRIMETHYLACETOPYRUVATE
- Synonyms
- ETHYL 5,5-DIMETHYL-2,4-DIOXOHEXANOATE;(Z)-ethyl 2-hydroxy-5,5-diMethyl-4-oxohex-2-enoate;AKOS MSC-0258;-2,4-dioxohexanoate;Ethyl pivaloylpyruvate;Ethyl trimethyacetopyruvate;ETHYL TRIMETHYLACETOPYRUVATE;1ETHYL TRIMETHYLACETOPYRUVATE;Ethyl trimethylacetopyruvate,98%;Ethyl trimethyacetopyruvate, 98+%
- CBNumber:
- CB4133355
- Molecular Formula:
- C10H16O4
- Molecular Weight:
- 200.23
- MDL Number:
- MFCD00052319
- MOL File:
- 13395-36-3.mol
- MSDS File:
- SDS
| Boiling point | 64 °C |
|---|---|
| Density | 1.046±0.06 g/cm3(Predicted) |
| refractive index | 1.4700 |
| Flash point | 68-70°C/0.5mm |
| storage temp. | 2-8°C |
| pka | 6.98±0.46(Predicted) |
| form | clear liquid |
| color | Light yellow to Brown |
| BRN | 510374 |
| InChI | InChI=1S/C10H16O4/c1-5-14-9(13)7(11)6-8(12)10(2,3)4/h5-6H2,1-4H3 |
| InChIKey | NIMKIMUBJFWPTD-UHFFFAOYSA-N |
| SMILES | C(OCC)(=O)C(=O)CC(=O)C(C)(C)C |
| CAS DataBase Reference | 13395-36-3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312 | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 23-24/25 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
ETHYL TRIMETHYLACETOPYRUVATE price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1326 | Ethyl Trimethylacetopyruvate >98.0%(GC) | 13395-36-3 | 1g | $83 | 2026-04-30 | Buy |
| TCI Chemical | E1326 | Ethyl Trimethylacetopyruvate >98.0%(GC) | 13395-36-3 | 5g | $255 | 2026-04-30 | Buy |
| Biosynth | NAA39536 | Ethyl Trimethylacetopyruvate | 13395-36-3 | 50g | $590 | 2026-06-04 | Buy |
| Apolloscientific | OR30152 | Ethyl 5,5-dimethyl-2,4-dioxohexanoate 97% | 13395-36-3 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR30152 | Ethyl 5,5-dimethyl-2,4-dioxohexanoate 97% | 13395-36-3 | 5g | $37 | 2026-06-04 | Buy |
ETHYL TRIMETHYLACETOPYRUVATE Chemical Properties,Uses,Production
Synthesis
75-97-8
95-92-1
13395-36-3
A mixture of pinacolone (740 mmol) and diethyl oxalate (820 mmol) was added dropwise to a solution of sodium ethoxide (prepared by dissolving 740 mmol of sodium in 450 mL of ethanol) at room temperature, followed by stirring the reaction for 1 hour at 78 °C. Upon completion of the reaction, the reaction mixture was cooled to room temperature and slowly poured into a pre-cooled aqueous 5 M hydrochloric acid solution (800 mL). Extraction was carried out with methyl tert-butyl ether (300 mL each time, 3 times in total), and the combined organic phases were washed with saturated aqueous sodium chloride solution (500 mL) and dried over anhydrous sodium sulfate. After filtration, the solvent was removed by distillation under reduced pressure to afford the target product ethyl 5,5-dimethyl-2,4-dioxohexanoate as a red liquid. Product weight: 140 g, yield: 93.3%. Mass spectrum (ES+): m/z 199 ([M+H]+). Nuclear magnetic resonance hydrogen spectrum (1H NMR, CDCl3): δ 6.5 (1H, s, CH), 4.3 (2H, q, OCH2), 1.35 (3H, t, CH3), 1.15 (9H, s, 3×CH3).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 18, p. 4383 - 4388
[2] Journal of Organic Chemistry, 1997, vol. 62, # 17, p. 5908 - 5919
[3] Patent: WO2009/71707, 2009, A1. Location in patent: Page/Page column 43
[4] Chinese Chemical Letters, 2016, vol. 27, # 4, p. 566 - 570
[5] Chinese Chemical Letters, 2016, vol. 27, # 2, p. 251 - 255
ETHYL TRIMETHYLACETOPYRUVATE Preparation Products And Raw materials
ETHYL TRIMETHYLACETOPYRUVATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Kemai Material Technology Co., Ltd | 17830741407 | sales@chem47.com | China | 1904 | 58 |
| Creasyn Finechem(Tianjin) Co., Ltd. | 022-83946278 13820372920 | sales@creasyn.com | China | 968 | 68 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Lastest Price from ETHYL TRIMETHYLACETOPYRUVATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 1ETHYL TRIMETHYLACETOPYRUVATE
13395-36-3
|
$1.00 | 1KG | 98%-99.9% | 100kg | Career Henan Chemical Co |
-
- 1ETHYL TRIMETHYLACETOPYRUVATE
13395-36-3
- $1.00
- 98%-99.9%
- Career Henan Chemical Co
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