8-[(trans-4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(3-fluoro-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
![8-[(trans-4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(3-fluoro-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one Structure](CAS/20240320/GIF/2750707-05-0.gif)
- CAS No.
- 2750707-05-0
- Chemical Name:
- 8-[(trans-4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(3-fluoro-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
- Synonyms
- 8-[(trans-4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(3-fluoro-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-[(trans-4-aminocyclohexyl)methyl]-6-[2-chloro-4-(3-fluoro-2-pyridinyl)phenyl]-2-(methylamino)-
- CBNumber:
- CB413423799
- Molecular Formula:
- C24H22ClFN6O3
- Molecular Weight:
- 496.92
- MDL Number:
- MOL File:
- 2750707-05-0.mol
- MSDS File:
- SDS
8-[(trans-4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(3-fluoro-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one Properties
| Boiling point | 676.6±65.0 °C(Predicted) |
|---|---|
| Density | 1.421±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) |
| pka | 6.86±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
8-[(trans-4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(3-fluoro-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0182653 | MRIA9 98.88% | 2750707-05-0 | 5mg | $780 | 2026-06-04 | Buy |
| ChemScene | CS-0182653 | MRIA9 98.88% | 2750707-05-0 | 10mg | $1246 | 2026-06-04 | Buy |
| ChemScene | CS-0182653 | MRIA9 98.88% | 2750707-05-0 | 25mg | $2600 | 2026-06-04 | Buy |
| ChemScene | CS-0182653 | MRIA9 98.88% | 2750707-05-0 | 50mg | $4171 | 2026-06-04 | Buy |
| ApexBio Technology | BA3001 | MRIA9 | 2750707-05-0 | 1mg | $960 | 2026-05-06 | Buy |
8-[(trans-4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(3-fluoro-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one Chemical Properties, Uses, Production
Uses
MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC50 values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively[1].
in vivo
MRIA9 shows high oral bioavailability (F = 75-80%)[1].
IC 50
SIK1; SIK2; SIK3
References
[1] Roberta Tesch, et al. Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors. J Med Chem. 2021 Jun 24;64(12):8142-8160. DOI:10.1021/acs.jmedchem.0c02144
[2] Monika Raab, et al. The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells. Cancers 2021, 13(15), 3658.
8-[(trans-4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(3-fluoro-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
8-[(trans-4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(3-fluoro-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
2750707-05-0 (8-[(trans-4-Aminocyclohexyl)methyl]-6-[2-chloro-4-(3-fluoro-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one) Related Search:
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