leucettamine A
- CAS No.
- 151124-32-2
- Chemical Name:
- leucettamine A
- Synonyms
- leucettamine A;5,8,11,14,17,20-Triacontahexaene-3,28-diol, 2,29-diamino-, (2R,3S,5Z,8Z,11Z,14Z,17Z,20Z,28S,29R)-
- CBNumber:
- CB41345986
- Molecular Formula:
- C30H52N2O2
- Molecular Weight:
- 472.75
- MDL Number:
- MFCD00918127
- MOL File:
- 151124-32-2.mol
leucettamine A Chemical Properties,Uses,Production
Uses
Leucettamol A is an inhibitor of Ubc13 (ubiquitin E2 enzyme)-Uev1A interaction, with an IC50 of 50 μg/mL. Leucettamol A can potentially activate the expression of cancer suppressor p53 and is a precursor of anticancer agents. Leucettamol A can be isolated from a marine sponge, Leucetta aff. Microrhaphis[1][2].
References
[1] Sachiko Tsukamoto, et al. Leucettamol A: a new inhibitor of Ubc13-Uev1A interaction isolated from a marine sponge, Leucetta aff. Microrhaphis. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6319-20. DOI:10.1016/j.bmcl.2008.10.110
[2] Kimberli M Helms, et al. Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K. Nat Prod Commun. 2011 Oct;6(10):1411-6. PMID:22164771
leucettamine A Preparation Products And Raw materials
Raw materials
Preparation Products
leucettamine A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
