9-((S)-3-Hydroxy-2-(phosphonomethoxy)propyl)adenine
- CAS No.
- 92999-29-6
- Chemical Name:
- 9-((S)-3-Hydroxy-2-(phosphonomethoxy)propyl)adenine
- Synonyms
- (S)-HPMPA;GS 0577;(S)-9-(3-Hydroxy-2-phosphonomethoxypropyl)adenine;(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine;9-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]adenine;9-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]-9H-purine-6-amine;[[(S)-2-(6-Amino-9H-purin-9-yl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid;(S)-[[[1-(6-Amino-9H-purin-9-yl)-3-hydroxy-2-propyl]oxy]methyl]phosphonic Acid;(S)-(((1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic acid;[[(1S)-1-(Hydroxymethyl)-2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid
- CBNumber:
- CB41386329
- Molecular Formula:
- C9H14N5O5P
- Molecular Weight:
- 303.21
- MDL Number:
- MOL File:
- 92999-29-6.mol
- MSDS File:
- SDS
| Melting point | 255-257 °C |
|---|---|
| Boiling point | 719.6±70.0 °C(Predicted) |
| Density | 1.91±0.1 g/cm3(Predicted) |
| pka | 2.31±0.10(Predicted) |
| InChI | InChI=1S/C9H14N5O5P/c10-8-7-9(12-3-11-8)14(4-13-7)1-6(2-15)19-5-20(16,17)18/h3-4,6,15H,1-2,5H2,(H2,10,11,12)(H2,16,17,18)/t6-/m0/s1 |
| InChIKey | FRPXSOOHWNMLPH-LURJTMIESA-N |
| SMILES | P(CO[C@H](CO)CN1C2C(N=C1)=C(N)N=CN=2)(=O)(O)O |
| FDA UNII | CJC8PO1KQ3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
9-((S)-3-Hydroxy-2-(phosphonomethoxy)propyl)adenine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | NH137606 | (S)-HPMPA | 92999-29-6 | 5g | $5841 | 2026-06-04 | Buy |
| Biosynth | NH137606 | (S)-HPMPA | 92999-29-6 | 10g | $9086 | 2026-06-04 | Buy |
| aablocks | AA00H1IN | (S)-(((1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic acid 95+% | 92999-29-6 | 50mg | $377 | 2026-05-28 | Buy |
| aablocks | AA00H1IN | (S)-(((1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic acid 95+% | 92999-29-6 | 250mg | $1133 | 2026-05-28 | Buy |
| Chemenu | CM138758 | (S)-(((1-(6-amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic acid 95% | 92999-29-6 | 1g | $1262 | 2026-05-26 | Buy |
9-((S)-3-Hydroxy-2-(phosphonomethoxy)propyl)adenine Chemical Properties, Uses, Production
Description
9-((S)-3-Hydroxy-2-(phosphonomethoxy)propyl)adenine [(S)-HPMPA] is a non-cyclic nucleotide analogue that acts as a potent and selective inhibitor of African swine fever virus (ASFV) replication. It has been reported that (S)-HPMPA exerts a specific, dose-dependent inhibitory effect on viral DNA synthesis. Furthermore, (S)-HPMPA also inhibits the production of late viral proteins (particularly IP-73) in ASFV-infected MS and Vero cells[1].
Preparation
9-(S)-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) was prepared from 9-(S)-(2,3-dihydroxypropyl)adenine (DHPA) via its 3-O-chloromethanephosphonate[2].
References
[1] O. Arzuza . (1988). Inhibition of African swine fever virus DNA synthesis by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine. Biochemical and Biophysical Research Communications, 154 1, Pages 27-32. https://doi.org/10.1016/0006-291X(88)90644-4
[2] A Holý, I R. (1987). Stereospecific syntheses of 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA). Nucleic Acids Symposium Series, 18, 33–36.
9-((S)-3-Hydroxy-2-(phosphonomethoxy)propyl)adenine Preparation Products And Raw materials
Raw materials
Preparation Products
9-((S)-3-Hydroxy-2-(phosphonomethoxy)propyl)adenine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Nucleosides Biotech Co., Ltd. | 15981919713 15981919713 | sales@nucleosides.com | China | 471 | 58 |
| NINGBO INNO PHARMCHEM CO.,LTD. | 86-574-27787657 | info@dearchem.com | China | 4607 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| Shanghai QianYan Bio-technology Co., Ltd | 02781293128 | orders@biochemsafebuy.com | China | 9904 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| ROSEWA HOLDING GROUP CO.,LIMITED | +86-023-62871537 | sales@rosewachem.com | China | 2812 | 58 |
| NewCan Biotech Limited | +86-571-86912261 19975279805 | sales@newcanbio.com | China | 9984 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 | sales@tcisct.com | China | 29717 | 58 |
| Hangzhou FuRun Pharmaceutical Technology Co., Ltd | 15658004993 | 1900830611@qq.com | China | 980 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +86-15658003402 | sales@newcanbio.com | China | 1980 | 58 |
