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VNPP433-3β

VNPP433-3β structure

CAS No.: 1630820-51-7

Chemical Name:: VNPP433-3β

Synonyms: VNPP433-3β;1H-Benzimidazole, 1-[(3β)-3-(1H-imidazol-1-yl)androsta-5,16-dien-17-yl]-

CBNumber:: CB414296192

Molecular Formula:: C29H34N4

Molecular Weight:: 438.61

MDL Number:

MOL File:: 1630820-51-7.mol

MSDS File:: SDS

Last updated:2025-04-18 09:52:17

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VNPP433-3β Properties

Melting point	180-184 °C
Boiling point	645.531±65.00 °C(Press: 760.00 Torr)(predicted)
Density	1.292±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	6.883±0.10(predicted)
form	Solid
color	Light yellow to yellow

VNPP433-3β price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-1047639	VNPP433-3β 98.01%	1630820-51-7	1mg	$585	2026-06-04	Buy
ChemScene	CS-1047639	VNPP433-3β 98.01%	1630820-51-7	5mg	$1300	2026-06-04	Buy
ChemScene	CS-1047639	VNPP433-3β 98.01%	1630820-51-7	10mg	$2167	2026-06-04	Buy
ChemScene	CS-1047639	VNPP433-3β 98.01%	1630820-51-7	25mg	$4333	2026-06-04	Buy
ChemScene	CS-1047639	VNPP433-3β 98.01%	1630820-51-7	50mg	$6933	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-1047639	1mg	$585	Buy
CS-1047639	5mg	$1300	Buy
CS-1047639	10mg	$2167	Buy
CS-1047639	25mg	$4333	Buy
CS-1047639	50mg	$6933	Buy

VNPP433-3β Chemical Properties, Uses, Production

Uses

VNPP433-3β is a molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2. VNPP433-3β inhibits proliferation of cancer cell LNCaP, C4-2B and CWR22Rv1 with GI50 of 0.2, 0.3 and 0.31 μM. VNPP433-3β exhibits good pharmacokinetic characters in CD-1 mouse and inhibits tumor growth in the CWR22Rv1 xenograft mouse model[1].

References

[1] Thankan RS, et al., Salinization Dramatically Enhance the Anti-Prostate Cancer Efficacies of AR/AR-V7 and Mnk1/2 Molecular Glue Degraders, Galeterone and VNPP433-3β Which Outperform Docetaxel and Enzalutamide in CRPC CWR22Rv1 Xenograft Mouse Model. Bioorg Chem. 2023 Oct;139:106700. DOI:10.1016/j.bioorg.2023.106700

VNPP433-3β Preparation Products And Raw materials

Raw materials

Preparation Products

VNPP433-3β Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

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VNPP433-3β 1H-Benzimidazole, 1-[(3β)-3-(1H-imidazol-1-yl)androsta-5,16-dien-17-yl]- 1630820-51-7