5-Hydroxy-6-nitropyridine-3-carboxylic acid
- CAS No.
- 59288-43-6
- Chemical Name:
- 5-Hydroxy-6-nitropyridine-3-carboxylic acid
- Synonyms
- 5-hydroxy-6-nitronicotinic acid;6-Nitro-5-hydroxy Nicotinic Acid;3-Hydroxy-2-nitro-5-pyridinecarboxylic acid;5-Hydroxy-6-nitropyridine-3-carboxylic acid;5-Hydroxy-6-nitro-3-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 5-hydroxy-6-nitro-
- CBNumber:
- CB41471289
- Molecular Formula:
- C6H4N2O5
- Molecular Weight:
- 184.11
- MDL Number:
- MFCD11044358
- MOL File:
- 59288-43-6.mol
- MSDS File:
- SDS
| Boiling point | 572.4±50.0 °C(Predicted) |
|---|---|
| Density | 1.745±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | -1.53±0.10(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C6H4N2O5/c9-4-1-3(6(10)11)2-7-5(4)8(12)13/h1-2,9H,(H,10,11) |
| InChIKey | OODZZMDHMOPHHY-UHFFFAOYSA-N |
| SMILES | C1=NC([N+]([O-])=O)=C(O)C=C1C(O)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P |
5-Hydroxy-6-nitropyridine-3-carboxylic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Strem Chemicals | 07-0177 | 5-Hydroxy-6-nitronicotinic acid, 95% 95% | 59288-43-6 | 10g | $800 | 2026-04-30 | Buy |
| Strem Chemicals | 07-0177 | 5-Hydroxy-6-nitronicotinic acid, 95% 95% | 59288-43-6 | 5g | $1200 | 2026-04-30 | Buy |
| Matrix Scientific | 121313 | 5-Hydroxy-6-nitronicotinic acid | 59288-43-6 | 250.00mg | $37 | 2026-05-18 | Buy |
| Matrix Scientific | 121313 | 5-Hydroxy-6-nitronicotinic acid | 59288-43-6 | 1.00g | $131 | 2026-05-18 | Buy |
| Matrix Scientific | 121313 | 5-Hydroxy-6-nitronicotinic acid | 59288-43-6 | 5.00g | $648 | 2026-05-18 | Buy |
5-Hydroxy-6-nitropyridine-3-carboxylic acid Chemical Properties, Uses, Production
Uses
5-Hydroxy-6-nitropyridine-3-carboxylic acid is a 5-hydroxynicotinic acid (H948565) derivative used in the preparation of aminoheteroaryl protein kinase inhibitors.
Synthesis
27828-71-3
59288-43-6
1. Synthesis of 6-nitro-5-hydroxynicotinic acid (B2): 5-hydroxynicotinic acid (B1) (7.0 g, 50 mmol) was dissolved in concentrated H2SO4 and 9 mL of 90% fuming HNO3 (9 mL) was added slowly. The reaction mixture was transferred to a sealed tube and the reaction was stirred at 55-60°C for 4 days. Upon completion of the reaction, the mixture was slowly poured into ice water and the pH was adjusted with 50% NaOH solution to 3. Subsequently, the aqueous phase was saturated by the addition of MgSO4 and extracted with isopropanol (4 x 45 mL). The organic phases were combined and concentrated under reduced pressure to remove the isopropanol to give 5.93 g (64% yield) of B2 as a yellow solid. The mass spectrum (APCI) showed (M + H)+ of 185. 1H-NMR (DMSO-d6) δ 8.01 (d, 1H, Ar-H), 8.41 (d, 1H, Ar-H).
References
[1] Patent: US2006/46991, 2006, A1. Location in patent: Page/Page column 45-46
[2] Patent: WO2006/21886, 2006, A1. Location in patent: Page/Page column 77
[3] Patent: WO2014/184234, 2014, A1. Location in patent: Page/Page column 55; 56
[4] Patent: CN105555786, 2016, A. Location in patent: Paragraph 0241
5-Hydroxy-6-nitropyridine-3-carboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang Jing Kang Technology Co.Ltd. | 13933818572 | 1519554262@qq.com | China | 1785 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Shanghai QianYan Bio-technology Co., Ltd | 02781293128 | orders@biochemsafebuy.com | China | 9904 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Shanghai QiQiao Biological Technology Co., Ltd. | 021-37653318 15221675714 | 515366396@qq.com | China | 2087 | 58 |
| Cool Pharm, Ltd | 021-58581007 18019463053 | sales@coolpharm.com | China | 9999 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
View Latest Price from 5-Hydroxy-6-nitropyridine-3-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | 5-Hydroxy-6-nitronicotinic acid
59288-43-6
|
$1500.00 | 1g | 97 | 500 Kg | R&D Scientific Inc. |
-
- 5-Hydroxy-6-nitronicotinic acid
59288-43-6
- $1500.00
- 97
- R&D Scientific Inc.
