8-Bromo-6-chloroimidazo[1,2-b]pyridazine
![8-Bromo-6-chloroimidazo[1,2-b]pyridazine Structure](CAS/GIF/933190-51-3.gif)
- CAS No.
- 933190-51-3
- Chemical Name:
- 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
- Synonyms
- 8-broMo-6-chloroiMidazo[1;8-Bromo-6-chloroimidazo[1,2-b]pyridazine;IMidazo[1,2-b]pyridazine, 8-broMo-6-chloro-;8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE ISO 9001：2015 REACH
- CBNumber:
- CB41479957
- Molecular Formula:
- C6H3BrClN3
- Molecular Weight:
- 232.47
- MDL Number:
- MFCD11520890
- MOL File:
- 933190-51-3.mol
- MSDS File:
- SDS
| Density | 2.03±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 0.73±0.30(Predicted) |
| Appearance | Light yellow to brown Solid |
| InChI | InChI=1S/C6H3BrClN3/c7-4-3-5(8)10-11-2-1-9-6(4)11/h1-3H |
| InChIKey | LZEJQXOCRMRVNP-UHFFFAOYSA-N |
| SMILES | C12=NC=CN1N=C(Cl)C=C2Br |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
8-Bromo-6-chloroimidazo[1,2-b]pyridazine price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 51847 | 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE 97% | 933190-51-3 | 1G | $17 | 2026-04-30 | Buy |
| AstaTech | 51847 | 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE 97% | 933190-51-3 | 5G | $43 | 2026-04-30 | Buy |
| AstaTech | 51847 | 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE 97% | 933190-51-3 | 25G | $200 | 2026-04-30 | Buy |
| Matrix Scientific | 070349 | 8-Bromo-6-chloroimidazo[1,2-b]pyridazine | 933190-51-3 | 1.00g | $908 | 2026-05-18 | Buy |
| Matrix Scientific | 070349 | 8-Bromo-6-chloroimidazo[1,2-b]pyridazine | 933190-51-3 | 5.00g | $3428 | 2026-05-18 | Buy |
8-Bromo-6-chloroimidazo[1,2-b]pyridazine Chemical Properties, Uses, Production
Application
8-Bromo-6-chloroimidazole[1,2-B]pyridazine is a pyridazine organic compound that can be used as a pharmaceutical intermediate.
Synthesis
446273-59-2
621-62-5
![8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE](/CAS/GIF/933190-51-3.gif)
933190-51-3
3-Amino-4-bromo-6-chloropyridazine (15.7 g, 75.3 mmol) and chloroacetaldehyde diethyl acetal (13.9 g, 90.3 mmol) were reacted in isopropanol (150 mL) in the presence of p-toluenesulfonic acid (PTSA, 17.2 g, 90.3 mmol). The reaction mixture was heated to 80 °C and maintained at this temperature for 20 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The concentrated residue was neutralized with saturated sodium bicarbonate solution (300 mL) and then extracted with dichloromethane (200 mL × 3). The organic layers were combined, dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (200-300 mesh, petroleum ether:ethyl acetate = 3:1) to afford the target product, 8-bromo-6-chloroimidazo[1,2-b]pyridazine (17.2 g, 98% yield), as an orange solid.LC-MS analysis showed [M + H]+ m/z 231.9, 233.9, and retention time tR = 1.46 min.
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10414 - 10423
[2] Patent: US2013/109661, 2013, A1. Location in patent: Paragraph 0227-0228
[3] Patent: WO2013/64445, 2013, A1. Location in patent: Page/Page column 51
8-Bromo-6-chloroimidazo[1,2-b]pyridazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Bank Pharma Limited | 2221346380 17701603001 | bankpharma@163.com | China | 376 | 58 |
| Shanghai Hongle Biotechnology Co., Ltd | 021-56145923; 4001631568 | sales@honglebiotech.com | China | 1036 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Wuhan Luohua Medical Technology Co.,Ltd. | 13477084141; 13477084141 | sales@luohuapharm.com | China | 468 | 60 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
View Latest Price from 8-Bromo-6-chloroimidazo[1,2-b]pyridazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![8-Bromo-6-chloroimidazo[1,2-b]pyridazine pictures](https://img.chemicalbook.com/ProductImageEN/2020-10/Small/bd347b42-5bdc-45ff-973e-866e7a3f8697.png) |
2022-01-04 | 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
933190-51-3
|
1g | 98%minHPLC | 50kgs/month | Shanghai Rlavie Technology Co ltd | ||
![8-Bromo-6-chloro-imidazo[1,2-b]pyridazine pictures](https://img.chemicalbook.com/ProductImageEN/2020-4/Small/e6918841-2e4d-437f-b4de-9bf6c8a23f50.jpg) |
2020-04-30 | 8-Bromo-6-chloro-imidazo[1,2-b]pyridazine
933190-51-3
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
![8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/0fcef65e-a605-45d3-9af1-9c6da382b4cc.jpg) |
2020-01-13 | 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE
933190-51-3
|
$1.00 | 1g | 99% | 10000KGS | Career Henan Chemical Co |
-
- 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
933190-51-3
- $0.00
- 98%minHPLC
- Shanghai Rlavie Technology Co ltd
-
- 8-Bromo-6-chloro-imidazo[1,2-b]pyridazine
933190-51-3
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE
933190-51-3
- $1.00
- 99%
- Career Henan Chemical Co
