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ChemicalBook >> CAS DataBase List >>3-Amino-4-bromo-6-chloropyridazine

3-Amino-4-bromo-6-chloropyridazine

3-Amino-4-bromo-6-chloropyridazine Structure
3-Amino-4-bromo-6-chloropyridazine structure
CAS No.
446273-59-2
Chemical Name:
3-Amino-4-bromo-6-chloropyridazine
Synonyms
3-Amino-4-bromo-6-chL;3-AMino-4-broMo-6-chlorop...;4-Bromo-6-chloro-3-pyridazinamine;3-PyridazinaMine,4-broMo-6-chloro-;4-bromo-6-chloro-3-pyridazineamine;3-Amino-4-bromo-6-chloropyridazine;3-Amino-4-bromo-6-chloropyridazine 98%;3-Amino-4-bromo-6-chloropyridazine ISO 9001：2015 REACH
CBNumber:
CB22134888
Molecular Formula:
C4H3BrClN3
Molecular Weight:
208.44
MDL Number:
MFCD11520891
MOL File:
446273-59-2.mol
Last updated:2025-08-29 17:52:28
Product description Number Pack Size Price
3-Amino-4-bromo-6-chloropyridazine AldrichCPR CDS020016 100 mg $73.1
4-Bromo-6-chloropyridazin-3-amine B680470 50g $1595
4-BROMO-6-CHLOROPYRIDAZIN-3-AMINE 95.00% HCH0044316 10G $1785.63
4-Bromo-6-chloropyridazin-3-amine 95% 3H30-D-15 25g $1198
4-BROMO-6-CHLOROPYRIDAZIN-3-AMINE 95.00% HCH0044316 5G $1277.43
More product size
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3-Amino-4-bromo-6-chloropyridazine Properties

Boiling point 385.4±37.0 °C(Predicted)
Density 1.960
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
form powder
pka 1.93±0.10(Predicted)
color Light brown to brown
InChI InChI=1S/C4H3BrClN3/c5-2-1-3(6)8-9-4(2)7/h1H,(H2,7,9)
InChIKey FGOWNGCSUSKHQI-UHFFFAOYSA-N
SMILES C1(N)=NN=C(Cl)C=C1Br
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H319-H335-H312+H332-H315
Precautionary statements  P280-P305+P351+P338-P362+P364
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN2811
HS Code  2933998090

3-Amino-4-bromo-6-chloropyridazine price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS020016 3-Amino-4-bromo-6-chloropyridazine AldrichCPR 100 mg $73.1 2025-07-31 Buy
TRC B680470 4-Bromo-6-chloropyridazin-3-amine 446273-59-2 50g $1595 2021-12-16 Buy
American Custom Chemicals Corporation HCH0044316 4-BROMO-6-CHLOROPYRIDAZIN-3-AMINE 95.00% 446273-59-2 10G $1785.63 2021-12-16 Buy
SynQuest Laboratories 3H30-D-15 4-Bromo-6-chloropyridazin-3-amine 95% 446273-59-2 25g $1198 2021-12-16 Buy
American Custom Chemicals Corporation HCH0044316 4-BROMO-6-CHLOROPYRIDAZIN-3-AMINE 95.00% 446273-59-2 5G $1277.43 2021-12-16 Buy
Product number Packaging Price Buy
CDS020016 100 mg $73.1 Buy
B680470 50g $1595 Buy
HCH0044316 10G $1785.63 Buy
3H30-D-15 25g $1198 Buy
HCH0044316 5G $1277.43 Buy

3-Amino-4-bromo-6-chloropyridazine Chemical Properties,Uses,Production

Appearance

Pale-yellow to yellow-brown Solid

Uses

4-Bromo-6-chloropyridazin-3-amine is a compound involved in the preparation of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors.

Synthesis

6-Chloropyridazin-3-amine

5469-69-2

3-Amino-4-bromo-6-chloropyridazine

446273-59-2

Example I (1) Bromine (9.71 g, 3.15 mL, 60.75 mmol) was slowly added dropwise to a mixed solution containing 3-amino-6-chloropyridazine (7.87 g, 60.75 mmol), methanol (115 mL) and sodium bicarbonate (10.22 g, 121.67 mmol). The reaction mixture was stirred at room temperature for 16 hours and then filtered. Water (500 mL) was added to the filtrate and subsequently extracted with ethyl acetate (3 × 500 mL). The organic layers were combined and concentrated under reduced pressure. The resulting residue was purified by fast chromatography using 1:1 hexane/ethyl acetate as eluent, resulting in 5.40 g of 3-amino-4-bromo-6-chloropyridazine in 43% yield.

References

[1] Patent: WO2014/9305, 2014, A1. Location in patent: Page/Page column 29
[2] Patent: US2015/203498, 2015, A1. Location in patent: Paragraph 0155; 0156; 0157
[3] Patent: WO2009/100375, 2009, A1. Location in patent: Page/Page column 44-45
[4] Patent: WO2010/42699, 2010, A1. Location in patent: Page/Page column 114-115
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10414 - 10423

3-Amino-4-bromo-6-chloropyridazine synthesis

5469-69-2
446273-59-2
Synthesis of 3-Amino-4-bromo-6-chloropyridazine from 6-Chloropyridazin-3-amine

3-Amino-4-bromo-6-chloropyridazine Preparation Products And Raw materials

Raw materials

6-Chloropyridazin-3-amine Sodium bicarbonate Methanol

Preparation Products

3-Amino-4-bromo-6-chloropyridazine Suppliers

Global( 268)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangsu Magic Biotechnology Co., Ltd
+undefined13921770081 SVP01@magicbiotech.cn China 92 58
Jinan Zhonghan Chemical Technology Co., LTD.
+undefined15066662237 3281004549@qq.com China 291 58
Apeloa production Co.,Limited 		+8619933239880 admin@apcl.com.cn China 861 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16513 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10405 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Supplier Advantage
Jiangsu Magic Biotechnology Co., Ltd
58
Jinan Zhonghan Chemical Technology Co., LTD.
58
Apeloa production Co.,Limited 		58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Hubei xin bonus chemical co. LTD 		58

View Lastest Price from 3-Amino-4-bromo-6-chloropyridazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Amino-4-bromo-6-chloropyridazine pictures 2025-11-18 3-Amino-4-bromo-6-chloropyridazine
446273-59-2
 US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited
3-Amino-4-bromo-6-chloropyridazine pictures 2025-10-13 3-Amino-4-bromo-6-chloropyridazine
446273-59-2
 US $1.60-6.60 / kg 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
3-Amino-4-bromo-6-chloropyridazine pictures 2025-08-29 3-Amino-4-bromo-6-chloropyridazine
446273-59-2
 US $0.00-0.00 / kg 1kg 99% 1 Jinan Ruitong Biotech Co., Ltd.

3-Amino-4-bromo-6-chloropyridazine Spectrum

3-Amino-4-bromo-6-chloropyridazine(446273-59-2)1HNMR

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3-Amino-4-bromo-6-chloropyridazine 4-Bromo-6-chloro-3-pyridazinamine 3-AMino-4-broMo-6-chlorop... 4-bromo-6-chloro-3-pyridazineamine 3-PyridazinaMine,4-broMo-6-chloro- 3-Amino-4-bromo-6-chL 3-Amino-4-bromo-6-chloropyridazine ISO 9001：2015 REACH 3-Amino-4-bromo-6-chloropyridazine 98% 446273-59-2 Risdiplam