GTCpFE
- CAS No.
- 1588866-45-8
- Chemical Name:
- GTCpFE
- Synonyms
- GTCpFE;2-Butenedioic acid (2E)-, 1-[[4-[[2-(acetyloxy)benzoyl]oxy]phenyl]methyl] 4-ethyl ester
- CBNumber:
- CB414907504
- Molecular Formula:
- C22H20O8
- Molecular Weight:
- 412.39
- MDL Number:
- MOL File:
- 1588866-45-8.mol
- MSDS File:
- SDS
GTCpFE Chemical Properties, Uses, Production
Uses
GTCpFE inhibits IKKα/β in the NF-κB pathway with anti-inflammatory activities and blocks p65 nuclear entry, which consists of Dimethyl fumarate (DMF) (HY-17363) linked to Aspirin (ASA) (HY-14654). GTCpFE exhibits selective anti-cancer stem-like cell (CSC) activity by reducing mammosphere growth and the CD44+ CD24- immunophenotype. GTCpFE inhibits breast cancer stem cells, an important NFκB- and PGE2-dependent phenotype in aggressive cancers[1][2].
References
[1] Kastrati I, et al. Design and synthesis of hybrid drugs to target inflammatory pathways in breast cancer[J]. Cancer Research, 2015, 75(15_Supplement): 4497-4497.
[2] Kastrati I, et al. A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties. BMC Cancer. 2015 Nov 4;15:845. DOI:10.1186/s12885-015-1868-7
GTCpFE Preparation Products And Raw materials
Raw materials
Preparation Products
GTCpFE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
