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GSI-18

GSI-18 structure

CAS No.: 362653-62-1

Chemical Name:: GSI-18

Synonyms: GSI-18;2-Thiophenesulfonamide, N-[(6R,9S)-5,6,7,8,9,10-hexahydro-6,9-methanobenzocycloocten-11-yl]-, rel-

CBNumber:: CB414907908

Molecular Formula:: C17H19NO2S2

Molecular Weight:: 333.47

MDL Number:

MOL File:: 362653-62-1.mol

MSDS File:: SDS

Last updated:2025-04-18 09:52:16

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GSI-18 Properties

Boiling point	505.985±60.00 °C(Press: 760.00 Torr)(predicted)
Density	1.356±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	10.610±0.20(predicted)

GSI-18 Chemical Properties, Uses, Production

Uses

GSI-18 is a γ-secretase inhibitor with anticancer activity. GSI-18 inhibits the attachment-free growth of pancreatic cancer cells by inhibiting Notch signaling[1].

References

[1] Mullendore, et al. "Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer." Clinical Cancer Research 15.7 (2009): 2291-2301. DOI:10.1158/1078-0432.CCR-08-2004

GSI-18 Preparation Products And Raw materials

Raw materials

Preparation Products

GSI-18 Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

362653-62-1 (GSI-18) Related Search:

DELTA-LIKE PROTEIN 4/DLL4 PROTEIN, MOUSE (HEK293, FC) NOTCH 3 Protein, HUMAN (HEK293, HIS-AVI) Jagged-1/JAG1 Protein, Rat (HEK293, His) cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid Jagged-1 (188-204) TFA

Dibenzazepine

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GSI-18 2-Thiophenesulfonamide, N-[(6R,9S)-5,6,7,8,9,10-hexahydro-6,9-methanobenzocycloocten-11-yl]-, rel- 362653-62-1