4-Keto-4,5,6,7-tetrahydrothianaphthene
- CAS No.
- 13414-95-4
- Chemical Name:
- 4-Keto-4,5,6,7-tetrahydrothianaphthene
- Synonyms
- 6,7-DIHYDROBENZO[B]THIOPHEN-4(5H)-ONE;AKOS 92215;2H-thiochroMene;AKOS BBS-00000945;RARECHEM AK MA K003;6,7-Dihydrobenzothiophen-4-one;6,7-DIHYDRO-4-BENZO(B)THIOPHENE;TETRAHYDROBENZO(B)THIOPHEN-4-ONE;4-Oxotetrahydrobenzo(b)thiophene;6,7-DIHYDROBENZO[B]THIOPHEN-4-ONE
- CBNumber:
- CB4149507
- Molecular Formula:
- C8H8OS
- Molecular Weight:
- 152.21
- MDL Number:
- MFCD00005861
- MOL File:
- 13414-95-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 38-40 °C(lit.) |
|---|---|
| Boiling point | 120 °C (10 mmHg) |
| Density | 1.245±0.06 g/cm3(Predicted) |
| refractive index | 1.5895-1.5915 |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in chloroform. |
| form | <38°C Solid,>40°C Liquid |
| color | White to yellow |
| BRN | 112276 |
| InChI | InChI=1S/C8H8OS/c9-7-2-1-3-8-6(7)4-5-10-8/h4-5H,1-3H2 |
| InChIKey | GJEKNELSXNSYAQ-UHFFFAOYSA-N |
| SMILES | S1C2=C(C(=O)CCC2)C=C1 |
| FDA UNII | TA3LE3X96K |
| EPA Substance Registry System | Benzo[b]thiophen-4(5H)-one, 6,7-dihydro- (13414-95-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-24/25-36/37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4-Keto-4,5,6,7-tetrahydrothianaphthene price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | K3603 | 6,7-Dihydro-4-benzo[b]thiophenone 98% | 13414-95-4 | 1g | $40 | 2023-01-07 | Buy |
| Sigma-Aldrich | K3603 | 6,7-Dihydro-4-benzo[b]thiophenone 98% | 13414-95-4 | 10g | $380 | 2023-01-07 | Buy |
| TCI Chemical | D5714 | 6,7-Dihydro-4-benzo[b]thiophenone | 13414-95-4 | 1G | $31 | 2026-04-30 | Buy |
| TCI Chemical | D5714 | 6,7-Dihydro-4-benzo[b]thiophenone | 13414-95-4 | 5G | $102 | 2026-04-30 | Buy |
| AstaTech | 60148 | 6,7-DIHYDROBENZO[B]THIOPHEN-4-ONE 97% | 13414-95-4 | 1G | $40 | 2026-04-30 | Buy |
4-Keto-4,5,6,7-tetrahydrothianaphthene Chemical Properties,Uses,Production
Chemical Properties
white to yellow low melting solid or liquid after
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs and is also used in medicine.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 17, p. 87, 1980 DOI: 10.1002/jhet.5570170118
Synthesis
4653-11-6
13414-95-4
General procedure: 4-(2-Thienyl)butyric acid (0.75 mmol, 1.0 eq.), trifluoroacetic anhydride (TFAA, 2.25 mmol, 3 eq.), and trifluoroacetic acid (TFA, 0.8 mL) were added to a 10 mL glass reaction vial equipped with a screw cap. The reaction mixture was stirred at room temperature for 12 h. The reaction process was monitored by thin layer chromatography (TLC) or gas chromatography-mass spectrometry (GC-MS). Upon completion of the reaction, the solvent was removed under reduced pressure and the resulting residue was purified by silica gel fast column chromatography (eluent: hexane/ethyl acetate mixed system) to finally obtain the target product 6,7-dihydro-4-keto-5-benzothiophene (6a).
References
[1] Tetrahedron Letters, 2018, vol. 59, # 10, p. 869 - 872
[2] Tetrahedron Letters, 2003, vol. 44, # 21, p. 4007 - 4010
[3] Heterocycles, 1996, vol. 43, # 1, p. 127 - 131
[4] Patent: WO2010/76188, 2010, A1. Location in patent: Page/Page column 17-19
[5] Patent: WO2005/77932, 2005, A2. Location in patent: Page/Page column 208
4-Keto-4,5,6,7-tetrahydrothianaphthene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| skychemical Co.Ltd | 021-20960837,QQ1332204249 | sales@skychemical.com | China | 3338 | 55 |
| Jinan Type Chemical Co., Ltd. | 0531-88062576 13791023792 | sales@typechem.com | China | 76 | 58 |
| Jinan Hergy Biomedical Technology Co., Ltd.， | 19285513406 | hyqt2011@126.com | China | 161 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
View Lastest Price from 4-Keto-4,5,6,7-tetrahydrothianaphthene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE
13414-95-4
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2020-01-10 | 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE
13414-95-4
|
$1.00 | 1g | 97% | 100kg | Career Henan Chemical Co |
-
- 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE
13414-95-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE
13414-95-4
- $1.00
- 97%
- Career Henan Chemical Co
