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4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE

4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE structure

CAS No.: 13414-95-4

Chemical Name:: 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE

Synonyms: 6,7-DIHYDROBENZO[B]THIOPHEN-4(5H)-ONE;AKOS 92215;2H-thiochroMene;AKOS BBS-00000945;RARECHEM AK MA K003;6,7-Dihydrobenzothiophen-4-one;6,7-DIHYDRO-4-BENZO(B)THIOPHENE;TETRAHYDROBENZO(B)THIOPHEN-4-ONE;4-Oxotetrahydrobenzo(b)thiophene;6,7-DIHYDROBENZO[B]THIOPHEN-4-ONE

CBNumber:: CB4149507

Molecular Formula:: C8H8OS

Molecular Weight:: 152.21

MDL Number:: MFCD00005861

MOL File:: 13414-95-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:52

Product description	Number	Pack Size	Price
6,7-Dihydro-4-benzo[b]thiophenone 98%	K3603	1g	$40
6,7-Dihydro-4-benzo[b]thiophenone 98%	K3603	10g	$380
6,7-Dihydro-4-benzo[b]thiophenone	D5714	1G	$31
6,7-Dihydro-4-benzo[b]thiophenone	D5714	5G	$102
6,7-Dihydrobenzo[b]thiophen-4-one	D448325	5g	$155
More product size

Request For Quotation

4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE Properties

Melting point	38-40 °C(lit.)
Boiling point	120 °C (10 mmHg)
Density	1.245±0.06 g/cm3(Predicted)
refractive index	1.5895-1.5915
Flash point	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in chloroform.
form	<38°C Solid,>40°C Liquid
color	White to yellow
BRN	112276
InChI	InChI=1S/C8H8OS/c9-7-2-1-3-8-6(7)4-5-10-8/h4-5H,1-3H2
InChIKey	GJEKNELSXNSYAQ-UHFFFAOYSA-N
SMILES	S1C2=C(C(=O)CCC2)C=C1
FDA UNII	TA3LE3X96K
EPA Substance Registry System	Benzo[b]thiophen-4(5H)-one, 6,7-dihydro- (13414-95-4)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

Safety Statements

22-24/25-36/37/39-26

WGK Germany

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29349990

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	K3603	6,7-Dihydro-4-benzo[b]thiophenone 98%	13414-95-4	1g	$40	2023-01-07	Buy
Sigma-Aldrich	K3603	6,7-Dihydro-4-benzo[b]thiophenone 98%	13414-95-4	10g	$380	2023-01-07	Buy
TCI Chemical	D5714	6,7-Dihydro-4-benzo[b]thiophenone	13414-95-4	1G	$31	2026-03-19	Buy
TCI Chemical	D5714	6,7-Dihydro-4-benzo[b]thiophenone	13414-95-4	5G	$102	2026-03-19	Buy
TRC	D448325	6,7-Dihydrobenzo[b]thiophen-4-one	13414-95-4	5g	$155	2021-12-16	Buy

Product number	Packaging	Price	Buy
K3603	1g	$40	Buy
K3603	10g	$380	Buy
D5714	1G	$31	Buy
D5714	5G	$102	Buy
D448325	5g	$155	Buy

4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE Chemical Properties,Uses,Production

Chemical Properties

white to yellow low melting solid or liquid after

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs and is also used in medicine.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 17, p. 87, 1980 DOI: 10.1002/jhet.5570170118

Synthesis

4653-11-6

13414-95-4

General procedure: 4-(2-Thienyl)butyric acid (0.75 mmol, 1.0 eq.), trifluoroacetic anhydride (TFAA, 2.25 mmol, 3 eq.), and trifluoroacetic acid (TFA, 0.8 mL) were added to a 10 mL glass reaction vial equipped with a screw cap. The reaction mixture was stirred at room temperature for 12 h. The reaction process was monitored by thin layer chromatography (TLC) or gas chromatography-mass spectrometry (GC-MS). Upon completion of the reaction, the solvent was removed under reduced pressure and the resulting residue was purified by silica gel fast column chromatography (eluent: hexane/ethyl acetate mixed system) to finally obtain the target product 6,7-dihydro-4-keto-5-benzothiophene (6a).

References

[1] Tetrahedron Letters, 2018, vol. 59, # 10, p. 869 - 872
[2] Tetrahedron Letters, 2003, vol. 44, # 21, p. 4007 - 4010
[3] Heterocycles, 1996, vol. 43, # 1, p. 127 - 131
[4] Patent: WO2010/76188, 2010, A1. Location in patent: Page/Page column 17-19
[5] Patent: WO2005/77932, 2005, A2. Location in patent: Page/Page column 208

4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE Preparation Products And Raw materials

Raw materials

2-Thiophenebutanoyl chloride 4-(2-THIENYL)BUTYRIC ACID

Preparation Products

4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE Benzo[b]thiophene-4-propanoic acid, 4,5,6,7-tetrahydro- ETHYL 2-(4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-4-YL)ACETATE Benzo[b]thiophen-4-amine, 4,5,6,7-tetrahydro-, (-)- 2-Chloro-6,7-dihydrobenzo[b]thiophen-4(5H)-one

Thieno[3,2-e]benzothiazol-2-amine, 4,5-dihydro- 4H,5H,6H,7H,8H-thieno[3,2-c]azepin-4-one Methyl 4-Oxo-4,5,6,7-Tetrahydrobenzo[B]Thiophene-5-Carboxylate

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4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE Suppliers

Global( 147)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	9546	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Chembon Pharmaceutical Co., Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58

View Lastest Price from 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-11-18	4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE 13414-95-4	US $1.10 / g	1g	99.00%	100 Tons	Dideu Industries Group Limited
	2020-01-10	4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE 13414-95-4	US $1.00 / g	1g	97%	100kg	Career Henan Chemical Co

4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE
13414-95-4
US $1.10 / g
99.00%
Dideu Industries Group Limited

4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE
13414-95-4
US $1.00 / g
97%
Career Henan Chemical Co

4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE Spectrum

4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE(13414-95-4)¹HNMR 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE(13414-95-4)FT-IR 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE(13414-95-4)Raman

13414-95-4(4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE)Related Search:

2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE 2-PENTYL-6,7-DIHYDRO-5H-BENZO[B]THIOPHEN-4-ONE Tipentosin

AKOS 91475 AKOS 91482 AKOS 91460 AKOS 91474 RARECHEM AK MA K052

AKOS 91481 AKOS 91178 5-AMINO-6,7-DIHYDRO-5H-BENZO[B]THIOPHEN-4-ONE SPECS AP-836/41220430 AKOS 91417

AKOS 91236 AKOS 91181 5,5-Dibromo-6,7-dihydro5H-benzo[b]thiophen-4-one

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4-OXO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE 4-OXO-4,5,6,7-TETRAHYDROTHIANAPHTHENE 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE RARECHEM AK MA K003 4-Oxotetrahydrobenzo(b)thiophene 4-Keto-4,5,6,7-tetrahydrothianaphthalene 4-Keto-4,5,6,7-tetrahydrothianaphthene, GC 97% TETRAHYDROBENZO(B)THIOPHEN-4-ONE 6,7-DIHYDROBENZO[B]THIOPHEN-4-ONE 4-Keto-4,5,6,7-tetrahydrothianaphthene, 4-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene, 4-Oxo-4,5,6,7-tetrahydrothianaphthene 4,5,6,7-Tetrahydrobenzo[b]thiophene-4-one 4-Keto-4,5,6,7-tetrahydrothianaphthene,97% 6,7-Dihydrobenzothiophen-4-one 6,7-Dihydro-5H-benzo[b]thiophen-4-one 2H-thiochroMene 4,5,6,7-tetrahydro-1-benzothiophen-4-one 6,7-Dihydro-1-benzothiophen-4(5H)-one 4-Keto-4,5,6,7-tetrahydrothlanaphthene Benzo[b]thiophen-4(5H)-one, 6,7-dihydro- AKOS 92215 AKOS BBS-00000945 6,7-DIHYDRO-4-BENZO(B)THIOPHENE 6,7-DIHYDRO-4-BENZO[B]THIOPHENONE 6,7-DIHYDROBENZO[B]THIOPHEN-4(5H)-ONE 6,7-DIHYDROBENZO(B)THIOPHENE-4(5H)-ONE 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHEN 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE ISO 9001：2015 REACH 4,5,6,7-Tetrahydro-4-oxo-benzo[b]thiophene 6,7-dihydro-5H-1-benzothiophen-4-one 6,7-Dihydro-4-benzo[b]thiophenone 13414-95-4 Building Blocks Benzothiophenes Heterocyclic Building Blocks Heterocyclic Compounds