2,2-Difluoropent-4-enoic acid
- CAS No.
- 55039-89-9
- Chemical Name:
- 2,2-Difluoropent-4-enoic acid
- Synonyms
- 2,2-Difluoropent-4-enoic acid;4-Pentenoic acid, 2,2-difluoro-;2,2-Difluoro-4-pentenoicacid,97%;2,2-Difluoropent-4-enoic acid,98% (stabilized with MEHQ)
- CBNumber:
- CB41496972
- Molecular Formula:
- C5H6F2O2
- Molecular Weight:
- 136.1
- MDL Number:
- MFCD09800642
- MOL File:
- 55039-89-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P309-P310 | |||||||||
| Hazard Codes | Xi | |||||||||
| RIDADR | 3265 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | Ⅱ | |||||||||
| HS Code | 2916199590 | |||||||||
| NFPA 704 |
|
2,2-Difluoropent-4-enoic acid price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC6655 | 2,2-Difluoropent-4-enoic acid 95% | 55039-89-9 | 1g | $69 | 2026-06-04 | Buy |
| Apolloscientific | PC6655 | 2,2-Difluoropent-4-enoic acid 95% | 55039-89-9 | 5g | $211 | 2026-06-04 | Buy |
| Apolloscientific | PC6655 | 2,2-Difluoropent-4-enoic acid 95% | 55039-89-9 | 25g | $680 | 2026-06-04 | Buy |
| Matrix Scientific | 024692 | 2,2-Difluoropent-4-enoic acid | 55039-89-9 | 5.00g | $155 | 2026-05-18 | Buy |
| Matrix Scientific | 024692 | 2,2-Difluoropent-4-enoic acid | 55039-89-9 | 10.00g | $264 | 2026-05-18 | Buy |
2,2-Difluoropent-4-enoic acid Chemical Properties, Uses, Production
Uses
2,2-Difluoro-4-pentenoic acid is involved in the iodolactonization reaction to give the corresponding gamma- lactone, which is converted to prepare prepare 5-hydroxy-3,3-difluoropiperidine.
Synthesis
118337-48-7
55039-89-9
The general procedure for synthesizing 2,2-difluoro-4-pentenoic acid from allyl chlorodifluoroacetate is as follows: in Example 9, 100.0 g (0.59 mol) of allyl chlorodifluoroacetate, 42.2 g (0.65 mol) of zinc powder activated by the Fieser and Fieser methods, 96.7 g (0.88 mol) of trimethylchlorosilane and 400 mL of anhydrous acetonitrile were added to a glass autoclave and a trace amount of iodine was added as initiator. The reaction mixture was heated at 100 °C for 48 hours. Upon completion of the reaction, the precipitated zinc salt was removed by filtration and the filtrate was hydrolyzed with water. Subsequently, the reaction mixture was alkalized with 2N NaOH solution. The dark brown aqueous phase was extracted with pentane and then acidified with semi-concentrated hydrochloric acid before the product was extracted with ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated in a rotary evaporator and the residue was vacuum distilled. A final 59.4 g (74% yield) of the colorless oily product 2,2-difluoro-4-pentenoic acid was obtained with a boiling point of 73°-75°C/15.6 mbar.
References
[1] Chemical Research in Toxicology, 1995, vol. 8, # 5, p. 671 - 682
[2] Patent: US4892962, 1990, A
2,2-Difluoropent-4-enoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2,2-Difluoropent-4-enoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Shanghai Hekang Biotechnology Co., Ltd. | 17721021104 18939837085 | 2880152141@qq.com | China | 1840 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd. | 023-89130144 18523560356 | zhyong1011@163.com | China | 297 | 58 |
| Shanghai AQBioPharma Co., Ltd. | 13661411401 | yinglv.que@aqbiopharma.com.cn | China | 2976 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 028-83379370 13880556291 | tcy@tcypharm.com | China | 8696 | 58 |
