2,2-Difluoropropionic acid
- CAS No.
- 373-96-6
- Chemical Name:
- 2,2-Difluoropropionic acid
- Synonyms
- 2,2-Difluoropropanoic acid;2,2-DIFLUOROPROPIONIC ACID;Propanoic acid, 2,2-difluoro-;2,2-Difluoropropionic acid 97%
- CBNumber:
- CB1301258
- Molecular Formula:
- C3H4F2O2
- Molecular Weight:
- 110.06
- MDL Number:
- MFCD03093764
- MOL File:
- 373-96-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 38-45 °C |
|---|---|
| Boiling point | 25-30 °C/5 mmHg |
| Density | 1.316±0.06 g/cm3(Predicted) |
| Flash point | 25-30°C/5mm |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 1.34±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| InChI | InChI=1S/C3H4F2O2/c1-3(4,5)2(6)7/h1H3,(H,6,7) |
| InChIKey | PMWGIVRHUIAIII-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C(F)(F)C |
| CAS DataBase Reference | 373-96-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 34-36 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | 3261 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29159000 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| NFPA 704 |
|
2,2-Difluoropropionic acid price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 684686 | 2,2-Difluoropropionic acid 97% | 373-96-6 | 250mg | $648 | 2026-04-30 | Buy |
| TCI Chemical | D5531 | 2,2-Difluoropropionic Acid | 373-96-6 | 1G | $50 | 2026-04-30 | Buy |
| TRC | TRC-D455898-500MG | 2,2-Difluoropropionic acid | 373-96-6 | 500mg | $84 | 2026-06-03 | Buy |
| TRC | TRC-D455898-1G | 2,2-Difluoropropionic acid | 373-96-6 | 1g | $101 | 2026-06-03 | Buy |
| TRC | TRC-D455898-100MG | 2,2-Difluoropropionic acid | 373-96-6 | 100mg | $65 | 2026-06-03 | Buy |
2,2-Difluoropropionic acid Chemical Properties, Uses, Production
Uses
2,2-Difluoropropionic acid is a useful research chemical.
Application
2,2-Difluoropropionic acid is mainly used in biochemical research.
Chemical Properties
White powder
Synthesis
28781-85-3
373-96-6
The general procedure for synthesizing 2,2-difluoropropionic acid from ethyl 2,2-difluoropropionate was as follows: referring to Example G38, ethyl 2,2-difluoropropionate (1.2 g, 8.8 mmol) was dissolved in ethanol (26 mL), followed by the slow addition of 2N aqueous sodium hydroxide solution (26 mL). The reaction mixture was stirred at 0 °C, then gradually warmed to room temperature and continued stirring for 14 hours. Upon completion of the reaction, the reaction mixture was acidified to pH < 7 with 2N hydrochloric acid and then extracted with ether. The organic phases were combined, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 2,2-difluoropropionic acid (0.90 g, 92% yield). The product was an oil with the following 1H-NMR (CDCl3) data: δ 1.85 (3H, t, J = 19.0 Hz), 6.21 (1H, br s).
References
[1] Patent: EP1402900, 2004, A1
[2] Patent: US2004/53973, 2004, A1
[3] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, p. 1260 - 1263
[4] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 7, p. 1417 - 1420
[5] Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 1597 - 1601
2,2-Difluoropropionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BTC Pharmaceutical CO. Ltd | +86-15716293042 15716293042 | info@btcpharm.com | China | 822 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Latest Price from 2,2-Difluoropropionic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 2,2-Difluoropropionic acid
373-96-6
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-11 | 2,2-Difluoropropionic acid
373-96-6
|
100g | 97% | 100kg | Zjartspharm Co., Ltd | ||
 |
2025-12-25 | 2,2-Difluoropropionic acid
373-96-6
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2,2-Difluoropropionic acid
373-96-6
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2,2-Difluoropropionic acid
373-96-6
- $0.00
- 97%
- Zjartspharm Co., Ltd
-
- 2,2-Difluoropropionic acid
373-96-6
- 98%
- Henan Aochuang Chemical Co.,Ltd.
