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ChemicalBook >> CAS DataBase List >>4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one Structure
4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one structure
CAS No.
3032451-66-1
Chemical Name:
4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one
Synonyms
4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one;1(2H)-Phthalazinone, 4-[[3-[[3-(5-bromo-2-furanyl)-5,6-dihydro-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]-
CBNumber:
CB414980392
Molecular Formula:
C25H18BrFN6O3
Molecular Weight:
549.35
MDL Number:
MOL File:
3032451-66-1.mol
MSDS File:
SDS
Last updated:2025-08-21 14:05:29
Request For Quotation

4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one Properties

Density 1.715±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
solubility DMSO: Soluble
pka 12.059±0.40(predicted)
form Solid
color White to off-white

4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 39737 YCH1899 ≥98% 3032451-66-1 1mg $54 2026-04-30 Buy
Cayman Chemical 39737 YCH1899 ≥98% 3032451-66-1 5mg $257 2026-04-30 Buy
Cayman Chemical 39737 YCH1899 ≥98% 3032451-66-1 10mg $486 2026-04-30 Buy
ChemScene CS-0890941 YCH1899 99.39% 3032451-66-1 5mg $217 2026-06-04 Buy
ChemScene CS-0890941 YCH1899 99.39% 3032451-66-1 10mg $352 2026-06-04 Buy
Product number Packaging Price Buy
39737 1mg $54 Buy
39737 5mg $257 Buy
39737 10mg $486 Buy
CS-0890941 5mg $217 Buy
CS-0890941 10mg $352 Buy

4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one Chemical Properties,Uses,Production

Uses

YCH1899 is an orally active PARP inhibitor, with an IC50< 0.001 nM for PARP1/2. YCH1899 exhibits distinct antiproliferation activity against Olaparib (HY-10162)-resistant and Talazoparib (HY-16106)-resistant Capan-1 cells (Capan-1/OP and Capan-1/TP cells) , with IC50 values of 0.89 and 1.13 nM, respectively. YCH1899 has acceptable pharmacokinetic properties in rats[1].

in vivo

YCH1899 (5 mg/kg, intravenous injection ) has a moderate clearance rate in rats[1].
YCH1899 overcomes acquired Talazoparib resistance and has a significant regression of tumor volume in MDA-MB-436/OP (6.25, 12.5, and 25 mg/kg, orally, once a day for 27 days) and Capan-1/R-in vivo xenografts (12.5 and 25 mg/kg, orally, once a day for 21 days ) [1].

Animal Model:MDA-MB-436/OP xenografts and Capan-1/R-in vivo xenografts mice[1]
Dosage:12.5 and 25 mg/kg
Administration:Oral administration
Result:Inhibited MDA-MB-436/OP xenografts tumor growth with T/C of 36.74% and 15.29% at 12.5 and 25 mg/kg
Inhibited Capan-1/R xenografts tumor growth with T/C of 48.92% and 13.87% at 12.5 and 25 mg/kg.
Animal Model:rats[1]
Dosage:5 mg/kg
Administration:Intravenous injection
Result:Had a moderate clearance rate (24.5 mL/min/kg) and half-life (3.25 h).

IC 50

PARP-1: <0.001 nM (IC50); PARP-2: <0.001 nM (IC50); PARP3: 1.1 nM (IC50); PARP4: 1.0 nM (IC50); TNKS1: 3.8 nM (EC50); TNKS2: 12.4 nM (IC50); PARA6: 9.5 nM (IC50); PARP-7: 7.3 nM (IC50); ARTD10/PARP10: 10.8 nM (IC50); PARA11: 2.166 μM (IC50); human PARP12: 14.1 nM (IC50); PARP14: 35.914 μM (IC50); PARP15: 51.623 nM (IC50)

References

[1] Sun Y, et al. YCH1899, a Highly Effective Phthalazin-1(2H)-one Derivative That Overcomes Resistance to Prior PARP Inhibitors. J Med Chem. 2023 Aug 21. DOI:10.1021/acs.jmedchem.3c00821

4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2996 55
Guangzhou Younan Technology Co., Ltd 020-82000279 18988941452 YN_research@163.com China 2984 58
AnEasyTech Shanghai Co., Ltd. 13916181326 info@aneasytech.com China 192 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
Guangzhou Younan Technology Co., Ltd 58
AnEasyTech Shanghai Co., Ltd. 58

3032451-66-1(4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one)Related Search:

4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one Rucaparib Camsylate Rucaparib AZD2461 3-Pyridinecarbonitrile, 6-[4-[(1,2,3,4,5,6-hexahydro-5-oxobenzo[h]-1,6-naphthyridin-8-yl)methyl]-1-piperazinyl]-
PF-01367338

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4-(3-(3-(5-bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one 1(2H)-Phthalazinone, 4-[[3-[[3-(5-bromo-2-furanyl)-5,6-dihydro-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]- 3032451-66-1