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Rucaparib Camsylate

Rucaparib Camsylate Structure
Rucaparib Camsylate structure
CAS No.
1859053-21-6
Chemical Name:
Rucaparib Camsylate
Synonyms
Rucaparib Camsylate;Asciminib Impurity 1;Rucaparib monocamsylate;Rucaparib Camphosulfonate;Rucaparib monocamsylate, 10 mM in DMSO;6-fluoro-2-[4-(methylaminomethyl)phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one;8‐Fluoro‐2‐(4‐methylaminomethyl‐phenyl)‐1,3,4,5‐tetrahydro‐azepino[5,4,3‐cd] indol‐6‐one (S)‐camphorsulfonate Salt;8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazaborin-6-one camphorsulfonate;8-Fluoro-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate;8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H- azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7dimethyl-2-oxobicyclo [2.2.1] hept-1-yl) methanesulfonic acid salt
CBNumber:
CB03147535
Molecular Formula:
C29H34FN3O5S
Molecular Weight:
555.67
MDL Number:
MOL File:
1859053-21-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
Rucaparib camsylate ≥98% (HPLC) PZ0036 5 mg $116
Rucaparib camsylate ≥98% (HPLC) PZ0036 25 mg $467
Rucaparib (camsylate) ≥98% 40218 25mg $65
Rucaparib (camsylate) ≥98% 40218 50mg $124
Rucaparib (camsylate) ≥98% 40218 100mg $234
More product size
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Rucaparib Camsylate Properties

storage temp. Store at -20°C
solubility DMSO:79.63(Max Conc. mg/mL);143.31(Max Conc. mM)
form Solid
color Light yellow to gray
InChIKey INBJJAFXHQQSRW-STOWLHSFSA-N
SMILES FC1=CC(C(NCC2)=O)=C3C2=C(C4=CC=C(CNC)C=C4)NC3=C1.CC5(C)[C@@H]6CC[C@@]5(CS(O)(=O)=O)C(C6)=O
NCI Dictionary of Cancer Terms rucaparib camsylate
FDA UNII 41AX9SJ8KO
NCI Drug Dictionary rucaparib camsylate
UNSPSC Code 12352202
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Warning
Hazard statements  H361-H341
Precautionary statements  P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Repr. 2

Rucaparib Camsylate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0036 Rucaparib camsylate ≥98% (HPLC) 1859053-21-6 5 mg $116 2026-04-30 Buy
Sigma-Aldrich PZ0036 Rucaparib camsylate ≥98% (HPLC) 1859053-21-6 25 mg $467 2026-04-30 Buy
Cayman Chemical 40218 Rucaparib (camsylate) ≥98% 1859053-21-6 25mg $65 2026-04-30 Buy
Cayman Chemical 40218 Rucaparib (camsylate) ≥98% 1859053-21-6 50mg $124 2026-04-30 Buy
Cayman Chemical 40218 Rucaparib (camsylate) ≥98% 1859053-21-6 100mg $234 2026-04-30 Buy
Product number Packaging Price Buy
PZ0036 5 mg $116 Buy
PZ0036 25 mg $467 Buy
40218 25mg $65 Buy
40218 50mg $124 Buy
40218 100mg $234 Buy

Rucaparib Camsylate Chemical Properties,Uses,Production

Uses

Rucaparib Camsylate is a novel DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1) inhibitor.

Definition

ChEBI: Rucaparib camsylate is a camphorsulfonate salt obtained by reaction of rucaparib with one molar equivalent of (1S,4R)-camphorsulfonic acid. It is an inhibitor of poly (ADP-ribose) polymerase and is used as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor. It is a camphorsulfonate salt and an azepinoindole. It contains a (S)-camphorsulfonate and a rucaparib(1+).

Biological Activity

Rucaparib is an inhibitor of the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It has been found to have anticancer activity in a number of cancers and has been approved for treatment of previously treated, BRCA-mutant ovarian cancer.

in vivo

Rucaparib (AG014699) monocamsylate and AG14584 significantly increase Temozolomide toxicity. Rucaparib (1 mg/kg) monocamsylate significantly increases Temozolomide-induced body weight loss. Rucaparib (0.1 mg/kg) monocamsylate results in a 50% increase in the temozolomide-induced tumor growth delay[1].
Rucaparib (10 mg/kg for i.p. or 50, 150 mg/kg for p.o.; daily for 5 days per week for 6 weeks) monocamsylate significantly inhibits the growth of the tumor, and there is one complete tumor regression and two persistent partial regressions[2].
Rucaparib (150 mg/kg; p.o.; once per week for 6 weeks or three times per week for 6 weeks) monocamsylate has greatest antitumor effect with three complete regressions[2].
Rucaparib monocamsylate enhances the antitumor activity of temozolomide and indicates complete and sustained tumor regression in NB1691 and SHSY5Y xenografts[6].

Animal Model:Female CD-1 nude mice aged 10-12 weeks with Capan-1 cells[2]
Dosage:10mg/kg or 50, 150 mg/kg
Administration:10mg/kg for i.p. or 50, 150 mg/kg for p.o.
Result:Significantly inhibited the growth of the tumor.

IC 50

PARP-1: 1.4 nM (Ki); PARP-2; PARP-3

storage

Store at -20°C

Rucaparib Camsylate Preparation Products And Raw materials

Raw materials

Preparation Products

Rucaparib Camsylate Suppliers

Global( 131)Suppliers
Supplier Tel Email Country ProdList Advantage
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 sales@sjar-tech.com China 556 58
Wuhan JiyunZen Tech Co., Ltd. 		+86-18062099985 Amyjiyunzen@yeah.net China 672 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21533 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32997 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Zhejiang ZETian Fine Chemicals Co. LTD 		18957127338 stella@zetchem.com China 2993 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19935 58
Shenzhen Excellent Biotech Co., Ltd. 		13480692018 ramyan@ex-biotech.com CHINA 951 58
Fuxin Pharmaceutical 		+86-021-021-50872116 contact@fuxinpharm.com China 9976 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9631 58
Supplier Advantage
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		58
Wuhan JiyunZen Tech Co., Ltd. 		58
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
BOC Sciences 		58
Shenzhen Excellent Biotech Co., Ltd. 		58
Fuxin Pharmaceutical 		58
Antai Fine Chemical Technology Co.,Limited 		58

View Lastest Price from Rucaparib Camsylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Rucaparib Camsylate pictures 2026-08-18 Rucaparib Camsylate
1859053-21-6
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Rucaparib monocamsylate pictures 2026-07-27 Rucaparib monocamsylate
1859053-21-6
 $47.00-172.00 99.82% 10g TargetMol Chemicals Inc.
Rucaparib Camsylate pictures 2026-06-30 Rucaparib Camsylate
1859053-21-6
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
  • Rucaparib Camsylate pictures
  • Rucaparib Camsylate
    1859053-21-6
  • $0.00
  • More Than 99%
  • BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Rucaparib Camsylate Spectrum

Rucaparib Camsylate(1859053-21-6)1HNMR

1859053-21-6(Rucaparib Camsylate)Related Search:

DL-CAMPHORIC ANHYDRIDE (+/-)-EXO EXO-2 3-CAMPHANEDIOL (+)-10-CAMPHORSULFONIMINE (-)-(8,8-DICHLOROCAMPHORYLSULFONYL)OXAZIRIDINE (1S)-(+)-Camphor-10-sulphonic acid
(1R)-(-)-10-Camphorsulfonic acid L(-)-10-Camphorsulfonyl chloride D-CAMPHOR (+)-(8,8-Dichlorocamphorylsulfonyl)oxaziridine (7,7-DIMETHYL-2-OXO-BICYCLO[2.2.1]HEPT-1-YL)-METHANESULFONYL CHLORIDE
EUROPIUM D-3-TRIFLUOROACETYLCAMPHORATE EUROPIUM TRIS[3-(HEPTAFLUOROPROPYLHYDROXYMETHYLENE)-(+)-CAMPHORATE] PF-01367338 (-)-3-(Trifluoroacetyl)camphor (2S)-Bornane-10,2-sultam
[(1S)-ENDO]-(+)-3-BROMO-10-CAMPHORSULFONIC ACID MONOHYDRATE Rucaparib (1S)-(-)-Camphorsulfonylimine

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Rucaparib Camsylate 8‐Fluoro‐2‐(4‐methylaminomethyl‐phenyl)‐1,3,4,5‐tetrahydro‐azepino[5,4,3‐cd] indol‐6‐one (S)‐camphorsulfonate Salt Rucaparib Camphosulfonate Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-, compd. with 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one (1:1) 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H- azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7dimethyl-2-oxobicyclo [2.2.1] hept-1-yl) methanesulfonic acid salt Rucaparib monocamsylate 8-Fluoro-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate Asciminib Impurity 1 Rucaparib monocamsylate, 10 mM in DMSO 6-fluoro-2-[4-(methylaminomethyl)phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazaborin-6-one camphorsulfonate 1859053-21-6 api