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ChemicalBook >> CAS DataBase List >>6-Bromo-benzo[b]thiophene-2-carboxy lic acid methyl ester

6-Bromo-benzo[b]thiophene-2-carboxy lic acid methyl ester

6-Bromo-benzo[b]thiophene-2-carboxy lic acid methyl ester Structure
6-Bromo-benzo[b]thiophene-2-carboxy lic acid methyl ester structure
CAS No.
360576-01-8
Chemical Name:
6-Bromo-benzo[b]thiophene-2-carboxy lic acid methyl ester
Synonyms
6-bromo-benzo[b]thiophene-2-carboxyL;Methyl 6-BroMobenzo[b]thiophene-2-carboxy;Methyl 6-Bromobenzothiophene-2-carboxylate;Piperazine,1-(3-chlorophenyl)-,hydrochloride(1:4);6-BroMobenzothiophene-2-carboxylic Acid Methyl Ester;6-BroMo-1-benzothiophene-2-carboxylic Acid Methyl Ester;Benzo[b]thiophene-2-carboxylic acid, 6-bromo-, methyl ester;Methyl 6-bromo-1-benzothiophene-2-carboxylate, 6-Bromo-2-(methoxycarbonyl)benzo[b]thiophene
CBNumber:
CB41501762
Molecular Formula:
C10H7BrO2S
Molecular Weight:
271.13
MDL Number:
MFCD07371541
MOL File:
360576-01-8.mol
Last updated:2026-09-12 18:52:22
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6-Bromo-benzo[b]thiophene-2-carboxy lic acid methyl ester Properties

Melting point 117-119°
Boiling point 358.9±22.0 °C(Predicted)
Density 1.622±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
form powder
color Off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
HazardClass  IRRITANT
HS Code  2934999090

6-Bromo-benzo[b]thiophene-2-carboxy lic acid methyl ester price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 004638 6-Bromobenzothiophene-2-carboxylic Acid Methyl Ester 360576-01-8 1g $502 2026-06-03 Buy
Apolloscientific OR12202 Methyl 6-bromobenzo[b]thiophene-2-carboxylate 97% 360576-01-8 1g $30 2026-06-04 Buy
Apolloscientific OR12202 Methyl 6-bromobenzo[b]thiophene-2-carboxylate 97% 360576-01-8 5g $85 2026-06-04 Buy
Apolloscientific OR12202 Methyl 6-bromobenzo[b]thiophene-2-carboxylate 97% 360576-01-8 25g $391 2026-06-04 Buy
Matrix Scientific 047910 Methyl 6-bromo-1-benzothiophene-2-carboxylate 360576-01-8 10.00g $62 2026-05-18 Buy
Product number Packaging Price Buy
004638 1g $502 Buy
OR12202 1g $30 Buy
OR12202 5g $85 Buy
OR12202 25g $391 Buy
047910 10.00g $62 Buy

6-Bromo-benzo[b]thiophene-2-carboxy lic acid methyl ester Chemical Properties,Uses,Production

Uses

6-Bromobenzo[b]thiophene-2-carboxylic acid methyl ester is used in the synthesis of benzothiophene derivatives as histone deacetylase inhibitors.

Synthesis

Methyl thioglycolate

2365-48-2

4-Bromo-2-fluorobenzaldehyde

57848-46-1

6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER

360576-01-8

GENERAL METHOD: Compound 1a or 1b (9.90 mmol) was dissolved in DMF (20 mL) under stirring conditions, followed by the sequential addition of methyl mercaptoacetate (10.9 mmol) and potassium carbonate (39.6 mmol). The reaction mixture was stirred continuously at 60 °C for 15 hours. After completion of the reaction, the DMF solvent was removed by distillation under reduced pressure. Water (50 mL) was added to the residue, which was then extracted with ethyl acetate (2 x 40 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered, and the solvent was removed by reduced pressure distillation to give the final target product, methyl 6-bromobenzo[b]thiophene-2-carboxylate (2a or 2b).

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 538 - 550
[2] Patent: WO2012/149413, 2012, A1. Location in patent: Page/Page column 58
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 1, p. 264 - 281
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7241 - 7257
[5] Patent: JP2015/89879, 2015, A. Location in patent: Paragraph 0016; 0047; 0048

6-Bromo-benzo[b]thiophene-2-carboxy lic acid methyl ester Preparation Products And Raw materials

Raw materials

Methyl thioglycolate 4-Bromo-2-fluorobenzaldehyde N,N-Dimethylformamide Potassium carbonate

Preparation Products

6-Bromo-benzo[b]thiophene (6-BroMobenzo[b]thiophen-2-yl)Methanol

6-Bromo-benzo[b]thiophene-2-carboxy lic acid methyl ester Suppliers

Global( 95)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
Chem-Stone Co.,Ltd. 020-82185713,82185709 13418171485 sales@chem-stone.com China 743 56
Shanghai Apichemical CO.,LTD 021-51370612; info@apichemical.com China 242 60
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Chengdu Aofan Pharmtech Co.,Ltd 15281070185; 13038283958 2865097598@qq.com China 111 55
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
Jia Xing Isenchem Co.,Ltd 66
Chemsky (shanghai) International Co.,Ltd 60
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
Chem-Stone Co.,Ltd. 56
Shanghai Apichemical CO.,LTD 60
Bide Pharmatech Ltd. 60
Chengdu Aofan Pharmtech Co.,Ltd 55
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55

View Lastest Price from 6-Bromo-benzo[b]thiophene-2-carboxy lic acid methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER pictures 2020-01-03 6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER
360576-01-8
 $1.00 1KG 99% 200kg Career Henan Chemical Co

6-Bromo-benzo[b]thiophene-2-carboxy lic acid methyl ester Spectrum

6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER(360576-01-8)1HNMR

360576-01-8(6-Bromo-benzo[b]thiophene-2-carboxy lic acid methyl ester)Related Search:

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Methyl 6-bromo-1-benzothiophene-2-carboxylate, 6-Bromo-2-(methoxycarbonyl)benzo[b]thiophene 6-BroMo-1-benzothiophene-2-carboxylic Acid Methyl Ester 6-BroMobenzothiophene-2-carboxylic Acid Methyl Ester Methyl 6-BroMobenzo[b]thiophene-2-carboxy 6-bromo-benzo[b]thiophene-2-carboxyL Benzo[b]thiophene-2-carboxylic acid, 6-bromo-, methyl ester Piperazine,1-(3-chlorophenyl)-,hydrochloride(1:4) Methyl 6-Bromobenzothiophene-2-carboxylate 360576-01-8 Others ,Pyridazines