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ChemicalBook >> CAS DataBase List >>6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER

6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER

6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER Structure
6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER structure
CAS No.
360576-01-8
Chemical Name:
6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER
Synonyms
6-bromo-benzo[b]thiophene-2-carboxyL;Methyl 6-BroMobenzo[b]thiophene-2-carboxy;Methyl 6-Bromobenzothiophene-2-carboxylate;Piperazine,1-(3-chlorophenyl)-,hydrochloride(1:4);6-BroMobenzothiophene-2-carboxylic Acid Methyl Ester;6-BroMo-1-benzothiophene-2-carboxylic Acid Methyl Ester;Benzo[b]thiophene-2-carboxylic acid, 6-bromo-, methyl ester;Methyl 6-bromo-1-benzothiophene-2-carboxylate, 6-Bromo-2-(methoxycarbonyl)benzo[b]thiophene
CBNumber:
CB41501762
Molecular Formula:
C10H7BrO2S
Molecular Weight:
271.13
MDL Number:
MFCD07371541
MOL File:
360576-01-8.mol
Last updated:2025-07-24 18:13:50
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6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER Properties

Melting point 117-119°
Boiling point 358.9±22.0 °C(Predicted)
Density 1.622±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
form powder
color Off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
HazardClass  IRRITANT
HS Code  2934999090

6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B680265 6-Bromobenzothiophene-2-carboxylicAcidMethylEster 360576-01-8 5g $305 2021-12-16 Buy
Usbiological 004638 6-Bromobenzothiophene-2-carboxylic Acid Methyl Ester 360576-01-8 1g $460 2021-12-16 Buy
Matrix Scientific 047910 Methyl 6-bromo-1-benzothiophene-2-carboxylate >95% 360576-01-8 5g $319 2021-12-16 Buy
SynQuest Laboratories 6H66-9-Y0 Methyl 6-bromobenzo[b]thiophene-2-carboxylate 360576-01-8 1g $42 2021-12-16 Buy
Matrix Scientific 047910 Methyl 6-bromo-1-benzothiophene-2-carboxylate >95% 360576-01-8 500mg $60 2021-12-16 Buy
Product number Packaging Price Buy
B680265 5g $305 Buy
004638 1g $460 Buy
047910 5g $319 Buy
6H66-9-Y0 1g $42 Buy
047910 500mg $60 Buy

6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER Chemical Properties,Uses,Production

Uses

6-Bromobenzo[b]thiophene-2-carboxylic acid methyl ester is used in the synthesis of benzothiophene derivatives as histone deacetylase inhibitors.

Synthesis

Methyl thioglycolate

2365-48-2

4-Bromo-2-fluorobenzaldehyde

57848-46-1

6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER

360576-01-8

GENERAL METHOD: Compound 1a or 1b (9.90 mmol) was dissolved in DMF (20 mL) under stirring conditions, followed by the sequential addition of methyl mercaptoacetate (10.9 mmol) and potassium carbonate (39.6 mmol). The reaction mixture was stirred continuously at 60 °C for 15 hours. After completion of the reaction, the DMF solvent was removed by distillation under reduced pressure. Water (50 mL) was added to the residue, which was then extracted with ethyl acetate (2 x 40 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered, and the solvent was removed by reduced pressure distillation to give the final target product, methyl 6-bromobenzo[b]thiophene-2-carboxylate (2a or 2b).

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 538 - 550
[2] Patent: WO2012/149413, 2012, A1. Location in patent: Page/Page column 58
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 1, p. 264 - 281
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7241 - 7257
[5] Patent: JP2015/89879, 2015, A. Location in patent: Paragraph 0016; 0047; 0048

6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Methyl thioglycolate 4-Bromo-2-fluorobenzaldehyde N,N-Dimethylformamide Potassium carbonate

Preparation Products

6-BROMO-BENZO[B]THIOPHENE (6-BroMobenzo[b]thiophen-2-yl)Methanol

6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER Suppliers

Global( 97)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29734 60
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29800 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Aromsyn Co., Ltd. 		+86-0571-85585865 +8613336024896 CB@aromsyn.com China 19183 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 43339 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Shandong Liteng Biotechnology Co. , Ltd. 		+86-18663721413 +86-15552573001 rosy@litengpharm.com China 3285 58
Cochemical Co. Ltd. 		+86-029-86115547 +86-17791676824 sales@cochemical.com China 3952 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Alchem Pharmtech,Inc. 		58
career henan chemical co 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Aromsyn Co., Ltd. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Aladdin Scientific 		58
Shandong Liteng Biotechnology Co. , Ltd. 		58
Cochemical Co. Ltd. 		58

View Lastest Price from 6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER pictures 2020-01-03 6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER
360576-01-8
 US $1.00 / KG 1KG 99% 200kg Career Henan Chemical Co

6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER Spectrum

6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER(360576-01-8)1HNMR

360576-01-8(6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER)Related Search:

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1of4

Methyl 6-bromo-1-benzothiophene-2-carboxylate, 6-Bromo-2-(methoxycarbonyl)benzo[b]thiophene 6-BroMo-1-benzothiophene-2-carboxylic Acid Methyl Ester 6-BroMobenzothiophene-2-carboxylic Acid Methyl Ester Methyl 6-BroMobenzo[b]thiophene-2-carboxy 6-bromo-benzo[b]thiophene-2-carboxyL Benzo[b]thiophene-2-carboxylic acid, 6-bromo-, methyl ester Piperazine,1-(3-chlorophenyl)-,hydrochloride(1:4) Methyl 6-Bromobenzothiophene-2-carboxylate 360576-01-8 Others ,Pyridazines