3-Amino-1,2-phthalic acid, dimethyl ester
- CAS No.
- 34529-06-1
- Chemical Name:
- 3-Amino-1,2-phthalic acid, dimethyl ester
- Synonyms
- dimethyl 3-aminophthalate;MFCD16293748;Apster Impurity 75.;Sitagliptin Impurity 37-d3;dimethyl 3-aminobenzene-1,2-dioate;3-Amino-phthalic acid dimethyl ester;dimethyl 3-aminobenzene-1,2-dicarboxylate;DiMethyl 3-aMino-1,2-benzenedicarboxylate;3-Amino-1,2-phthalic acid, dimethyl ester;Methyl 3-amino-2-(methoxycarbonyl)benzoate
- CBNumber:
- CB41502628
- Molecular Formula:
- C10H11NO4
- Molecular Weight:
- 209.2
- MDL Number:
- MFCD09029586
- MOL File:
- 34529-06-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331-H315-H319 |
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405 |
| HS Code | 2921420090 |
3-Amino-1,2-phthalic acid, dimethyl ester price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR924260 | Dimethyl 3-aminophthalate 98% | 34529-06-1 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR924260 | Dimethyl 3-aminophthalate 98% | 34529-06-1 | 5g | $37 | 2026-06-04 | Buy |
| Apolloscientific | OR924260 | Dimethyl 3-aminophthalate 98% | 34529-06-1 | 25g | $108 | 2026-06-04 | Buy |
| Apolloscientific | OR924260 | Dimethyl 3-aminophthalate 98% | 34529-06-1 | 100g | $413 | 2026-06-04 | Buy |
| Apolloscientific | OR924260 | Dimethyl 3-aminophthalate 98% | 34529-06-1 | 500g | $2026 | 2026-06-04 | Buy |
3-Amino-1,2-phthalic acid, dimethyl ester Chemical Properties, Uses, Production
Uses
Dimethyl 3-aminophthalate is a useful research chemical.
Synthesis
13365-26-9
34529-06-1
The general procedure for the synthesis of dimethyl 3-amino-phthalate from methyl 3-nitrophthalate was as follows: first, methyl 3-nitrophthalate was converted to the corresponding chloride by a chlorination reaction, followed by esterification to obtain dimethyl 3-nitrophthalate (100% yield). Next, the nitro group was reduced to an amino group by catalytic hydrogenation to obtain dimethyl 3-amino-phthalate (100% yield). Subsequently, diazotization of the amino group was followed by iodination to obtain dimethyl 3-iodophthalate (about 91% yield). Then, a saponification reaction was carried out on dimethyl 3-iodophthalate, followed by acidification to obtain 3-iodophthalic acid (yield about 93%). Finally, 3-iodophthalic acid was oxidized and reacted in the presence of KBrO3 and 0.73 M H2SO4 at 55-60 °C for 12 h to obtain water-soluble MIBX.Upon completion of the reaction, purification by evaporation, cooled milling and filtration yielded white solid MIBX (~70% yield, melting point 258-260 °C). The conversion of the process is nearly quantitative and can be monitored by 1H NMR spectroscopy.The physical properties of MIBX include IR (KBr) showing characteristic absorption peaks; 1H NMR (D2O, 300 MHz) and 13C NMR (D2O, 75 MHz) showing specific chemical shifts.
References
[1] Journal of Heterocyclic Chemistry, 1989, vol. 26, # 6, p. 1885 - 1886
[2] Tetrahedron Letters, 2002, vol. 43, # 4, p. 569 - 572
[3] Patent: US2004/30187, 2004, A1. Location in patent: Page 2; Sheet 1
[4] RSC Advances, 2015, vol. 5, # 60, p. 48861 - 48867
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 1, p. 285 - 288
3-Amino-1,2-phthalic acid, dimethyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Enantiotech Corporation Ltd | 760-85282375 15900088539 | sale02@enantiotech.com | China | 84 | 55 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 2000 | 58 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 3-Amino-1,2-phthalic acid, dimethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | Dimethyl 3-aminophthalate
34529-06-1
|
$139.50 | 25Kg/Drum | 98.00%HPLC | 5tons/month | Asia Chem I and E (Jiangsu) Co Ltd | |
 |
2020-01-05 | 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER
34529-06-1
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- Dimethyl 3-aminophthalate
34529-06-1
- $139.50
- 98.00%HPLC
- Asia Chem I and E (Jiangsu) Co Ltd
-
- 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER
34529-06-1
- $1.00
- 95-99%
- Career Henan Chemical Co
