4-Aminophthalic acid
- CAS No.
- 5434-21-9
- Chemical Name:
- 4-Aminophthalic acid
- Synonyms
- AKOS 92080;4-AminophthaL;4-aminophthalate;4-Aminophthalsure;RARECHEM AL BO 1135;4-Amnophthalic acid;4-AMINOPHTHALIC ACID;4-AminophthalicAcid>4-Aminophthalicacid,98%;4-Amino-o-phthalic acid
- CBNumber:
- CB8287890
- Molecular Formula:
- C8H7NO4
- Molecular Weight:
- 181.15
- MDL Number:
- MFCD00013985
- MOL File:
- 5434-21-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Aminophthalic acid 97% | 524716 | 1g | $58.8 |
| 4-Aminophthalic Acid >95.0%(T) | A1512 | 5g | $78 |
| 4-Aminophthalic Acid >95.0%(T) | A1512 | 25g | $230 |
| 4-Aminophthalic Acid | A627713 | 2.5g | $45 |
| 4-Aminophthalic Acid | A627713 | 5g | $60 |
| More product size | |||
| Melting point | 344 °C (dec.)(lit.) |
|---|---|
| Boiling point | 465.1±40.0 °C(Predicted) |
| Density | 1.551±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 3.41±0.10(Predicted) |
| form | powder to crystal |
| color | White to Gray to Brown |
| BRN | 2723405 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C8H7NO4/c9-4-1-2-5(7(10)11)6(3-4)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13) |
| InChIKey | OXSANYRLJHSQEP-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)=CC=C(N)C=C1C(O)=O |
| CAS DataBase Reference | 5434-21-9(CAS DataBase Reference) |
| FDA UNII | TZ6K337ZYS |
| EPA Substance Registry System | 4-Aminophthalic acid (5434-21-9) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P280g-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29224999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Aminophthalic acid price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 524716 | 4-Aminophthalic acid 97% | 5434-21-9 | 1g | $58.8 | 2022-05-15 | Buy |
| TCI Chemical | A1512 | 4-Aminophthalic Acid >95.0%(T) | 5434-21-9 | 5g | $78 | 2026-04-30 | Buy |
| TCI Chemical | A1512 | 4-Aminophthalic Acid >95.0%(T) | 5434-21-9 | 25g | $230 | 2026-04-30 | Buy |
| TRC | A627713 | 4-Aminophthalic Acid | 5434-21-9 | 2.5g | $45 | 2021-12-16 | Buy |
| TRC | A627713 | 4-Aminophthalic Acid | 5434-21-9 | 5g | $60 | 2021-12-16 | Buy |
4-Aminophthalic acid Chemical Properties,Uses,Production
Chemical Properties
Beige powder
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
610-27-5
5434-21-9
The general procedure for the synthesis of 4-amino phthalic acid from 4-nitrophthalic acid was as follows: 1 g (4.73 mmol) of 4-nitrophthalic acid was dissolved in 10 ml of anhydrous ethanol. The solution was stirred and degassed at room temperature and under argon protection. Subsequently, 50 mg of 5% palladium/carbon catalyst was added at once and hydrogen was passed into the solution for hydrogenation reaction. After 3 hours of reaction, the reaction mixture was filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated by evaporation to give an orange oily product with a mass of 820 mg and a yield of 96%. The structure of the product was confirmed by 1H NMR (DMSO-d6) with the following chemical shifts: 3.32 (1H, s), 5.95 (1H, s), 6.49-6.53 (2H, m), 7.46-7.50 (1H, d, J = 8.8 Hz), 12.33 (2H, COOH, s).
References
[1] Patent: US6689922, 2004, B1. Location in patent: Page column 20
[2] Patent: US6706725, 2004, B1. Location in patent: Page column 11
[3] Chemical Communications, 2017, vol. 53, # 62, p. 8751 - 8754
[4] Justus Liebigs Annalen der Chemie, 1881, vol. 208, p. 230
[5] Journal of the American Chemical Society, 1908, vol. 30, p. 1143
4-Aminophthalic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| ShenZhen H&D Pharmaceutical Technology Co., LTD | +8618627948422 | sale@hdimpurity.com | China | 3681 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2988 | 55 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
View Lastest Price from 4-Aminophthalic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-30 | 4-Aminophthalic acid
5434-21-9
|
US $167.44 / Kg/Drum | 25Kg/Drum | 98.50%HPLC | 6tons/month | Asia Chem I and E (Jiangsu) Co Ltd | |
 |
2026-03-20 | 4-Aminophthalic acid
5434-21-9
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-03-12 | Pomalidomide Impurity 7 | US $0.00-0.00 / mg | 10mg | 98% | 500mg | ShenZhen H&D Pharmaceutical Technology Co., LTD |
-
- 4-Aminophthalic acid
5434-21-9
- US $167.44 / Kg/Drum
- 98.50%HPLC
- Asia Chem I and E (Jiangsu) Co Ltd
-
- 4-Aminophthalic acid
5434-21-9
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Pomalidomide Impurity 7
- US $0.00-0.00 / mg
- 98%
- ShenZhen H&D Pharmaceutical Technology Co., LTD
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