4-Aminophthalic acid
- CAS No.
- 5434-21-9
- Chemical Name:
- 4-Aminophthalic acid
- Synonyms
- AKOS 92080;4-AminophthaL;4-aminophthalate;4-Aminophthalsure;RARECHEM AL BO 1135;4-Amnophthalic acid;4-AMINOPHTHALIC ACID;4-AminophthalicAcid>4-Aminophthalicacid,98%;4-Amino-o-phthalic acid
- CBNumber:
- CB8287890
- Molecular Formula:
- C8H7NO4
- Molecular Weight:
- 181.15
- MDL Number:
- MFCD00013985
- MOL File:
- 5434-21-9.mol
- MSDS File:
- SDS
| Melting point | 344 °C (dec.)(lit.) |
|---|---|
| Boiling point | 465.1±40.0 °C(Predicted) |
| Density | 1.551±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 3.41±0.10(Predicted) |
| color | White to Gray to Brown |
| BRN | 2723405 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C8H7NO4/c9-4-1-2-5(7(10)11)6(3-4)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13) |
| InChIKey | OXSANYRLJHSQEP-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)=CC=C(N)C=C1C(O)=O |
| CAS DataBase Reference | 5434-21-9(CAS DataBase Reference) |
| FDA UNII | TZ6K337ZYS |
| EPA Substance Registry System | 4-Aminophthalic acid (5434-21-9) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P280g-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29224999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Aminophthalic acid price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 524716 | 4-Aminophthalic acid 97% | 5434-21-9 | 1g | $58.8 | 2022-05-15 | Buy |
| TCI Chemical | A1512 | 4-Aminophthalic Acid >95.0%(T) | 5434-21-9 | 5g | $78 | 2026-04-30 | Buy |
| TCI Chemical | A1512 | 4-Aminophthalic Acid >95.0%(T) | 5434-21-9 | 25g | $230 | 2026-04-30 | Buy |
| Usbiological | 258408 | 4-Aminophthalic acid Asreported | 5434-21-9 | 50g | $355 | 2026-06-03 | Buy |
| Usbiological | 258408 | 4-Aminophthalic acid Asreported | 5434-21-9 | 100g | $489 | 2026-06-03 | Buy |
4-Aminophthalic acid Chemical Properties, Uses, Production
Chemical Properties
Beige powder
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
610-27-5
5434-21-9
The general procedure for the synthesis of 4-amino phthalic acid from 4-nitrophthalic acid was as follows: 1 g (4.73 mmol) of 4-nitrophthalic acid was dissolved in 10 ml of anhydrous ethanol. The solution was stirred and degassed at room temperature and under argon protection. Subsequently, 50 mg of 5% palladium/carbon catalyst was added at once and hydrogen was passed into the solution for hydrogenation reaction. After 3 hours of reaction, the reaction mixture was filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated by evaporation to give an orange oily product with a mass of 820 mg and a yield of 96%. The structure of the product was confirmed by 1H NMR (DMSO-d6) with the following chemical shifts: 3.32 (1H, s), 5.95 (1H, s), 6.49-6.53 (2H, m), 7.46-7.50 (1H, d, J = 8.8 Hz), 12.33 (2H, COOH, s).
References
[1] Patent: US6689922, 2004, B1. Location in patent: Page column 20
[2] Patent: US6706725, 2004, B1. Location in patent: Page column 11
[3] Chemical Communications, 2017, vol. 53, # 62, p. 8751 - 8754
[4] Justus Liebigs Annalen der Chemie, 1881, vol. 208, p. 230
[5] Journal of the American Chemical Society, 1908, vol. 30, p. 1143
4-Aminophthalic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Greenspring Biotechnology (Jiangsu) Co., Ltd. | 0523-87726088 13705266400 | 524535288@qq.com | China | 117 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
View Latest Price from 4-Aminophthalic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | 4-Aminophthalic acid
5434-21-9
|
$167.44 | 25Kg/Drum | 98.50%HPLC | 6tons/month | Asia Chem I and E (Jiangsu) Co Ltd | |
 |
2026-09-02 | 4-Aminophthalic acid
5434-21-9
|
$5.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-03-20 | 4-Aminophthalic acid
5434-21-9
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 4-Aminophthalic acid
5434-21-9
- $167.44
- 98.50%HPLC
- Asia Chem I and E (Jiangsu) Co Ltd
-
- 4-Aminophthalic acid
5434-21-9
- $5.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Aminophthalic acid
5434-21-9
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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