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2-Bromo-6-chloropyridin-3-amine

2-Bromo-6-chloropyridin-3-amine Structure
2-Bromo-6-chloropyridin-3-amine structure
CAS No.
1050501-88-6
Chemical Name:
2-Bromo-6-chloropyridin-3-amine
Synonyms
2-Bromo-6-chloro-3-pyridinamine;2-Bromo-6-chloropyridin-3-amine;2-bromo-3-amino-6-chloropyridine;3-AMINO-6-CHLORO-2-BROMOPYRIDINE;3-Amino-2-bromo-6-chloropyridine;3-Pyridinamine, 2-bromo-6-chloro-;2-Bromo-6-chloro-pyridin-3-ylamine;2-Bromo-6-chloropyridin-3-amine ISO 9001：2015 REACH
CBNumber:
CB41503175
Molecular Formula:
C5H4BrClN2
Molecular Weight:
207.46
MDL Number:
MFCD11504927
MOL File:
1050501-88-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:06:13
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2-Bromo-6-chloropyridin-3-amine Properties

Boiling point 330.3±37.0 °C(Predicted)
Density 1.834
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka -0.12±0.10(Predicted)
Appearance Light brown to brown Solid
InChI InChI=1S/C5H4BrClN2/c6-5-3(8)1-2-4(7)9-5/h1-2H,8H2
InChIKey OPKKXWUGXHSFQI-UHFFFAOYSA-N
SMILES C1C=C(N)C(Br)=NC=1Cl

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933399990

2-Bromo-6-chloropyridin-3-amine price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 231534 3-Amino-2-bromo-6-chloropyridine 1050501-88-6 1g $215 2026-06-03 Buy
Usbiological 231534 3-Amino-2-bromo-6-chloropyridine 1050501-88-6 5g $435 2026-06-03 Buy
Usbiological 231534 3-Amino-2-bromo-6-chloropyridine 1050501-88-6 25g $1231 2026-06-03 Buy
Biosynth FA55774 3-Amino-2-bromo-6-chloropyridine 1050501-88-6 5g $250 2026-06-04 Buy
Biosynth FA55774 3-Amino-2-bromo-6-chloropyridine 1050501-88-6 2g $250 2026-06-04 Buy
Product number Packaging Price Buy
231534 1g $215 Buy
231534 5g $435 Buy
231534 25g $1231 Buy
FA55774 5g $250 Buy
FA55774 2g $250 Buy

2-Bromo-6-chloropyridin-3-amine Chemical Properties, Uses, Production

Uses

2-Bromo-6-chloro-3-pyridinamine is a reactant used in the synthesis of kilogram quantities of an akt Kinase inhibitor. It is mainly used as starting material for the production of many pharmaceutical compounds.

Synthesis

5-Amino-2-chloropyridine

5350-93-6

2-Bromo-6-chloropyridin-3-amine

1050501-88-6

Step 1: Synthesis of 2-bromo-6-chloropyridin-3-amine Bromine (24.86 g, 155.57 mmol) was slowly added to a solution of acetic acid (383 mL) containing 6-chloropyridin-3-amine (20.00 g, 155.57 mmol) and sodium acetate (25.52 g, 311.14 mmol). The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the acetic acid was removed by rotary evaporator. The residue was dissolved in ethyl acetate (EtOAc) and washed sequentially with saturated aqueous sodium carbonate (Na2CO3) solution, water and brine. The organic layer was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated to afford the target product 2-bromo-6-chloropyridin-3-amine (32.20 g, 99.8% yield). Mass spectrometry analysis showed m/z = 206.96 ([M+H]+), which is consistent with the isotopic distribution pattern of Cl and Br.

References

[1] Patent: WO2012/80450, 2012, A1. Location in patent: Page/Page column 25
[2] Patent: WO2013/186335, 2013, A1. Location in patent: Page/Page column 87
[3] Patent: WO2013/186333, 2013, A1. Location in patent: Page/Page column 102
[4] Patent: WO2014/60411, 2014, A1. Location in patent: Page/Page column 56
[5] Patent: US2015/111868, 2015, A1. Location in patent: Paragraph 0856; 0857

2-Bromo-6-chloropyridin-3-amine Preparation Products And Raw materials

Raw materials

5-Amino-2-chloropyridine Sodium carbonate Sodium chloride Ethyl acetate Water

Preparation Products

tert-butyl 2-broMo-6-chloropyridin-3-ylcarbaMate 5-Chloro-1H-pyrrolo[3,2-b] pyridine

2-Bromo-6-chloropyridin-3-amine Suppliers

Global Suppliers ( 114)
Supplier Tel Email Country ProdList Advantage
Shanghai YuYuan Pharmaceutical Co., Ltd. 13052276172 product@yuyuanpharm.com China 401 55
shanghaiaoderuikanglimitedcompany 18902198068 18912886236 akslichenglong@163.com China 592 58
Changzhou Jienuo Pharmaceutical Technology Co., Ltd 13915093723 joinpharm@aliyun.com China 85 58
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 28-83379370 13880556291 tcy@tcypharm.com China 509 57
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Supplier Advantage
Shanghai YuYuan Pharmaceutical Co., Ltd. 55
shanghaiaoderuikanglimitedcompany 58
Changzhou Jienuo Pharmaceutical Technology Co., Ltd 58
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 57
Tetranov Biopharm 64
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Ennopharm Co., Ltd. 65

View Latest Price from 2-Bromo-6-chloropyridin-3-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-6-chloropyridin-3-amine pictures 2026-08-20 2-Bromo-6-chloropyridin-3-amine
1050501-88-6
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited
2-Bromo-6-chloropyridin-3-amine pictures 2025-04-04 2-Bromo-6-chloropyridin-3-amine
1050501-88-6
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

2-Bromo-6-chloropyridin-3-amine Spectrum

2-Bromo-6-chloropyridin-3-amine(1050501-88-6)1HNMR

1050501-88-6 (2-Bromo-6-chloropyridin-3-amine) Related Search:

2-Bromo-6-chloropyridine tert-butyl 2-broMo-6-chloropyridin-3-ylcarbaMate 2-Bromo-6-chloro-3-nitropyridine 6-Bromo-2-chloropyridin-3-amine Benzyl (2-bromo-6-chloropyridin-3-yl)carbamate
2-Bromo-4,6-dichloropyridin-3-amine

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2-Bromo-6-chloropyridin-3-amine 3-Amino-2-bromo-6-chloropyridine 3-AMINO-6-CHLORO-2-BROMOPYRIDINE 2-Bromo-6-chloro-3-pyridinamine 2-Bromo-6-chloro-pyridin-3-ylamine 3-Pyridinamine, 2-bromo-6-chloro- 2-Bromo-6-chloropyridin-3-amine ISO 9001：2015 REACH 2-bromo-3-amino-6-chloropyridine 1050501-88-6