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5-Amino-2-chloropyridine

5-Amino-2-chloropyridine Structure
5-Amino-2-chloropyridine structure
CAS No.
5350-93-6
Chemical Name:
5-Amino-2-chloropyridine
Synonyms
6-CHLOROPYRIDIN-3-AMINE;6-CHLORO-PYRIDIN-3-YLAMINE;AMINO CHLOROPYRIDINE;6-chloro-3-pyridinamine;3-AMINO-6-CHLOROPYRIDINE;Tobrasix;5-Amino-2-chL;TIMTEC-BB SBB004234;5-Amino-2-chlorpyridin;2-Chloro-5-pyridinamine
CBNumber:
CB0687779
Molecular Formula:
C5H5ClN2
Molecular Weight:
128.56
MDL Number:
MFCD00006243
MOL File:
5350-93-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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5-Amino-2-chloropyridine Properties

Melting point 81-83 °C(lit.)
Boiling point 205.39°C (rough estimate)
Density 1.2417 (rough estimate)
refractive index 1.5110 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 1.94±0.10(Predicted)
form powder to crystal
color White to Brown
BRN 108891
InChI InChI=1S/C5H5ClN2/c6-5-2-1-4(7)3-8-5/h1-3H,7H2
InChIKey QAJYCQZQLVENRZ-UHFFFAOYSA-N
SMILES C1=NC(Cl)=CC=C1N
CAS DataBase Reference 5350-93-6(CAS DataBase Reference)
FDA UNII 386QR22KDZ
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
HazardClass  IRRITANT
HS Code  29333999
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

5-Amino-2-chloropyridine price More Price(89)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 188778 5-Amino-2-chloropyridine 98% 5350-93-6 5g $161 2026-04-30 Buy
Sigma-Aldrich 188778 5-Amino-2-chloropyridine 98% 5350-93-6 1g $85 2023-06-20 Buy
TCI Chemical A1155 5-Amino-2-chloropyridine >98.0%(GC)(T) 5350-93-6 1g $23 2026-04-30 Buy
TCI Chemical A1155 5-Amino-2-chloropyridine >98.0%(GC)(T) 5350-93-6 5g $89 2026-04-30 Buy
Usbiological 160434 3-Amino-6-chloropyridine 5350-93-6 1g $418 2026-06-03 Buy
Product number Packaging Price Buy
188778 5g $161 Buy
188778 1g $85 Buy
A1155 1g $23 Buy
A1155 5g $89 Buy
160434 1g $418 Buy

5-Amino-2-chloropyridine Chemical Properties,Uses,Production

Chemical Properties

Light yellow to brown crystalline powder

Uses

5-Amino-2-chloropyridine was used in the synthesis of [2H5]2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine. It was used in identification and evaluation of molecularly imprinted polymers for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceuticals.

Definition

ChEBI: 3-Amino-6-chloropyridine is an aminopyridine.

General Description

5-Amino-2-chloropyridine undergoes Suzuki-Miyaura coupling with sterically hindered 2,6-dimethylphenylboronic acid. It undergoes facile temperature dependent displacement of chloride by bromide via Sandmeyer reaction to yield 2,5-dibromopyridine.

Synthesis

2-Chloro-5-nitropyridine

4548-45-2

5-Amino-2-chloropyridine

5350-93-6

General method: 2-chloro-5-nitropyridine (1 eq.), hexafluoroisopropanol (HFIP, 10 eq.) and iron powder (5 eq.) were added to the reaction tube and mixed. Subsequently, 2N aqueous hydrochloric acid solution was slowly added to the reaction mixture. The reaction mixture was stirred at room temperature for 30 minutes and then neutralized with saturated aqueous sodium bicarbonate (NaHCO3). The organic layer was extracted three times with saturated aqueous sodium bicarbonate solution and combined. The organic layers were subsequently washed with brine, dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford the target product 2-chloro-5-aminopyridine.

References

[1] Bulletin des Societes Chimiques Belges, 1988, vol. 97, # 1, p. 51 - 54
[2] Organic Letters, 2009, vol. 11, # 6, p. 1345 - 1348
[3] ACS Catalysis, 2014, vol. 4, # 6, p. 1777 - 1782
[4] New Journal of Chemistry, 2015, vol. 39, # 11, p. 8498 - 8504
[5] Tetrahedron Letters, 2017, vol. 58, # 37, p. 3646 - 3649

5-Amino-2-chloropyridine Preparation Products And Raw materials

Raw materials

6-Chloronicotinamide 2-Chloro-5-iodopyridine Iron 2-Chloro-5-nitropyridine-1-oxide Sodium bicarbonate
Boron trifluoride methyl sulfide complex 1,1,1,3,3,3-Hexafluoro-2-propanol 2-Amino-5-fluoropyridine 2-Chloro-5-nitropyridine Hydrochloric acid

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Preparation Products

5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID 2-Chloro-5-fluoropyridine 5-AMINOPYRIDINE-2-BORONIC ACID PINACOL ESTER 5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
3-Aminopyridine 5-Amino-2-hydroxypyridine 3-Pyridinamine,6-chloro-N-methyl-(9CI) ethyl 4,6-dichloro-1,5-naphthyridine-3-carboxylate 3-amino-6-chloro-1H-pyridine-2-thione

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5-Amino-2-chloropyridine Suppliers

Global( 562)Suppliers
Supplier Tel Email Country ProdList Advantage
LEWOO PHARMATECH (SHANGHAI) CO.,LTD 15800805830 miao@lewoopharma.com.cn China 994 58
Shanghai Qiao Chemical Science Co., Ltd 021-58892003 info@qiaochem.com China 6065 65
Shanghai Taijilin Industrial Co., Ltd. 02150630626 17717886015 kate@tajilin.com China 1340 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
Bridge Organics +1269-649-4200 ab@bridgeorganics.com United States 160 55
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
LEWOO PHARMATECH (SHANGHAI) CO.,LTD 58
Shanghai Qiao Chemical Science Co., Ltd 65
Shanghai Taijilin Industrial Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Liaoning Tianhua Chemical Co., Ltd. 69
Bridge Organics 55
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61

View Lastest Price from 5-Amino-2-chloropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-Amino-2-chloropyridine pictures 2026-09-11 5-Amino-2-chloropyridine
5350-93-6
 1KG 98% 100kg/month WUHAN FORTUNA CHEMICAL CO., LTD
5-Chloro-2-pyridinamine pictures 2026-09-02 5-Chloro-2-pyridinamine
5350-93-6
 $6.00 1KG 99% Henan Fengda Chemical Co., Ltd
5-Amino-2-chloropyridine pictures 2026-07-15 5-Amino-2-chloropyridine
5350-93-6
 $29.00 99.84% 10g TargetMol Chemicals Inc.

5-Amino-2-chloropyridine Spectrum

5-Amino-2-chloropyridine(5350-93-6)MS5-Amino-2-chloropyridine(5350-93-6)1HNMR5-Amino-2-chloropyridine(5350-93-6)13CNMR5-Amino-2-chloropyridine(5350-93-6)IR15-Amino-2-chloropyridine(5350-93-6)IR2

5350-93-6(5-Amino-2-chloropyridine)Related Search:

Clopidol 3-Aminophenol 2-Chloro-5-chloromethylpyridine 3-Aminopyridine 6-Aminocaproic acid
4-Dimethylaminopyridine 2-Chloro-5-nitropyridine 2-Chloro-3-cyanopyridine 2-Aminopyridine 2-Chloropyridine
Tris(hydroxymethyl)aminomethane Glycine Aminoethoxyvinyl glycine hydrochloride 2-chloro-5-cyanopyridine 2-Chloro-5-fluoropyridine
3-Bromo-6-chloro-2-methylpyridine 5-Bromo-2-chloropyridine 6-Chloro-2-methyl-3-nitropyridine

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3-PYRIDINAMINE, 6-CHLORO- 5-AMINO-2-CHLOROPYRIDINE 2-CHLORO-5-AMINOPYRIDINE TIMTEC-BB SBB004234 6-chloro-3-pyridinamine 3-Pyridinamine,6-chloro-(9CI) 5- BROMO-2-METHOXYPHENOL 5-Amino-2-chloropyridine ,98% 2-Chloro-5-pyridinamine 2-Chloropyridine-5-amine 3-Amino-6-chloropyridine,98% 5-Amino-2-chL 5-Amino-2-chloropyridine > 6-Chloro-4-methyl-5-pyridinecarboxylic acid 5-Amino-2-chloropyridine ISO 9001：2015 REACH 5-Amino-2-chlorpyridin Tobrasix 5-Amino-2-chloropyridine, 95% Lemborexant Impurity 62 3-AMINO-6-CHLOROPYRIDINE 6-CHLOROPYRIDIN-3-AMINE 6-CHLORO-PYRIDIN-3-YLAMINE AMINO CHLOROPYRIDINE 5-Amino-2-chloropyridine、6-Chloropyridin-3-amine 5350-93-6 5350-93-2 5350-96-6 226-322-3 Building Blocks HETERO CHLORIDE Pyridines Heterocyclic Building Blocks Halogenated Heterocycles Halopyridines Chloropyridines Chloropyridines Halopyridines Boronic Acid C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridines derivates PYRIDINE Amines blocks Pyridines pyridine derivative Pyridine Series Amino-pyridine series compounds of pyridine bc0001