1-N-Boc-3-(S)-Methylamino-piperidine
- CAS No.
- 912368-73-1
- Chemical Name:
- 1-N-Boc-3-(S)-Methylamino-piperidine
- Synonyms
- S-N-Boc-3-MethylaMino piperidine;N-Boc-3-(S)-Methylamino-piperidine;(S)-1-Boc-3-(MethylaMino)piperidine;(S)-1-N-BOC-3-METHYLAMINOPIPERIDINE;1-N-Boc-3-(S)-Methylamino-piperidine;(S)-1-Boc-3-(methylamino)piperidine 97%;(S)-1-Boc-3-(methylamino)piperidine;(S)-tert-Butyl 3-(MethylaMino)piperidine-1-carboxylate;tert-Butyl (S)-3-(methylamino)piperidine-1-carboxylate;Tert-butyl (3s)-3-(methylamino)piperidine-1-carboxylate
- CBNumber:
- CB41508675
- Molecular Formula:
- C11H22N2O2
- Molecular Weight:
- 214.3
- MDL Number:
- MFCD09752964
- MOL File:
- 912368-73-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 289℃ |
|---|---|
| Density | 1.01 |
| refractive index | 1.4600 |
| Flash point | 129℃ |
| storage temp. | 2-8°C |
| form | Liquid |
| pka | 10.10±0.20(Predicted) |
| color | Colorless to yellow |
| optical activity | 13.3°(C=1.00g/100mL CHCL3) |
| Sensitive | Moisture Sensitive |
| InChI | 1S/C11H22N2O2/c1-11(2,3)15-10(14)13-7-5-6-9(8-13)12-4/h9,12H,5-8H2,1-4H3/t9-/m0/s1 |
| InChIKey | XRRRUOWSHGFPTI-VIFPVBQESA-N |
| SMILES | CN[C@H]1CCCN(C1)C(=O)OC(C)(C)C |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H319-H400 | |||||||||
| Precautionary statements | P273-P301+P310+P330-P305+P351+P338 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 25-36-50 | |||||||||
| Safety Statements | 26-45-61 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Acute 1 Eye Irrit. 2 |
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| NFPA 704 |
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1-N-Boc-3-(S)-Methylamino-piperidine price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 735833 | (S)-1-Boc-3-(methylamino)piperidine 97% | 912368-73-1 | 500mg | $156 | 2023-01-07 | Buy |
| AstaTech | 56567 | (S)-1-N-BOC-3-METHYLAMINOPIPERIDINE 95% | 912368-73-1 | 0.25G | $18 | 2026-04-30 | Buy |
| AstaTech | 56567 | (S)-1-N-BOC-3-METHYLAMINOPIPERIDINE 95% | 912368-73-1 | 1G | $40 | 2026-04-30 | Buy |
| AstaTech | 56567 | (S)-1-N-BOC-3-METHYLAMINOPIPERIDINE 95% | 912368-73-1 | 5G | $145 | 2026-04-30 | Buy |
| Apolloscientific | OR315582 | (S)-1-Boc-3-(methylamino)piperidine 98% | 912368-73-1 | 1g | $44 | 2026-06-04 | Buy |
1-N-Boc-3-(S)-Methylamino-piperidine Chemical Properties, Uses, Production
Synthesis
50-00-0
625471-18-3
912368-73-1
General procedure for the synthesis of 1-N-BOC-3-(S)-methylaminopiperidine from formaldehyde and (S)-1-Boc-3-aminopiperidine: tert-butyl (5.0 g, 25 mmol) of (S)-3-aminopiperidine-1-carboxylate (5.0 g, 25 mmol) was added to a stirred aqueous formaldehyde (1.85 mL, 25 mmol, 37%) and suspension of molecular sieves in methanol and the reaction mixture was stirred at room temperature (24 °C) the reaction mixture was stirred for 24 hours. Subsequently, sodium borohydride (1.52 g, 40 mmol) was slowly added to the above mixture at room temperature and stirring was continued for 16 hours. Upon completion of the reaction, the reaction was quenched by the addition of ice water (30 mL) and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to afford 3.0 g of the crude product (S)-tert-butyl 3-(methylamino)piperidine-1-carboxylate as a light yellow liquid, which was used directly in the next step of the reaction.1H NMR (400 MHz, CDCl3) δ ppm: 1.38 (s, 9H), 1.5-1.7 (m, 4H), 1.71-1.90 (m 2H), 2.18-2.27 (m, 3H), 2.75-2.90 (m, 1H), 3.50-3.92 (m, 2H).
References
[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1061 - 1073
[2] Patent: WO2018/2437, 2018, A1. Location in patent: Page/Page column 99
1-N-Boc-3-(S)-Methylamino-piperidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Amber MolTech LLC | 086-010-62176588 | amber@jyamber.com | China | 10150 | 56 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 1-N-Boc-3-(S)-Methylamino-piperidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-10 | 1-N-Boc-3-(S)-Methylamino-piperidine
912368-73-1
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 1-N-Boc-3-(S)-Methylamino-piperidine
912368-73-1
- $1.00
- 99%
- Career Henan Chemical Co
