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SPIROXATRINE

SPIROXATRINE Structure
SPIROXATRINE structure
CAS No.
1054-88-2
Chemical Name:
SPIROXATRINE
Synonyms
R 5188;SPIROXATRINE;Spiroxatrine (R 5188);SPIROXATRINE (R 5188) SELECTIVE SEROTONI N 5;8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE;1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-;8-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;(+/-)-8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZA-SPIRO[4,5]DECAN-4-ONE;R 5188, (±)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one
CBNumber:
CB4157162
Molecular Formula:
C22H25N3O3
Molecular Weight:
379.45
MDL Number:
MFCD00055134
MOL File:
1054-88-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-30 11:39:11
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SPIROXATRINE Properties

Melting point 215.8-218.0 °C
Boiling point 602.8±55.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
storage temp. Store at RT
solubility 0.1 M HCl: moderately soluble
form powder
pka 15.03±0.20(Predicted)
color white
FDA UNII DR0QR50ALL

SAFETY

Risk and Safety Statements

WGK Germany  3

SPIROXATRINE price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 33415 Spiroxatrine ≥98% 1054-88-2 5mg $87 2026-04-30 Buy
Cayman Chemical 33415 Spiroxatrine ≥98% 1054-88-2 10mg $139 2026-04-30 Buy
Cayman Chemical 33415 Spiroxatrine ≥98% 1054-88-2 25mg $283 2026-04-30 Buy
Cayman Chemical 33415 Spiroxatrine ≥98% 1054-88-2 50mg $435 2026-04-30 Buy
Usbiological 466452 Spiroxatrine (R 5188) 1054-88-2 10mg $382 2026-06-03 Buy
Product number Packaging Price Buy
33415 5mg $87 Buy
33415 10mg $139 Buy
33415 25mg $283 Buy
33415 50mg $435 Buy
466452 10mg $382 Buy

SPIROXATRINE Chemical Properties,Uses,Production

Uses

Spiroxatrine (R 5188) is a SR-1A antagonist.

Definition

ChEBI: 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one is a member of imidazolidines.

Biological Activity

5-HT 1A antagonist. More active and selective than spiperone. Also a very potent α 2C adrenergic receptor antagonist.

in vivo

Spiroxatrine (1-25 ug for i.p., 5 days) increases hindpaw withdrawal latencies to thermal and mechanical stimulation in the nerve injury rat and Carrageenan (HY-125474)-induced rat inflammation model[3].
Spiroxatrine (4 mg/kg/day for i.p., 5 mins) increases the voluntary oral ethanol intake induced by Fluoxetine (HY-B0102) in the selectively bred alcohol-preferring P line of rats [4].

Animal Model:The nerve injury rat model and Carrageenan (HY-125474)-induced rat inflammation model[3]
Dosage:1, 10, 25 ug, 5 days
Administration:Intraperitoneal injection (i.p.)
Result:Increased hindpaw withdrawal latencies to thermal and mechanical stimulation.
Animal Model:Fluoxetine (HY-B0102) -induced reduction of ethanol Intake by the P Line of rats[4]
Dosage:4 mg/kg/day, 5 mins
Administration:Intraperitoneal injection (i.p.)
Result:Increased the voluntary oral ethanol intake induced by Fluoxetine (HY-B0102) in the selectively bred alcohol-preferring P line of rats.

IC 50

α2-adrenergic receptor; 5-HT1A Receptor: 3.94 nM (Ki); 5-HT1B/D Receptor: 224000 nM (Ki); 5-HT2 Receptor: 118.5 nM (Ki)

SPIROXATRINE Preparation Products And Raw materials

Raw materials

Preparation Products

SPIROXATRINE Suppliers

Global( 49)Suppliers
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Shaanxi Dideu Medichem Co. Ltd +86-17392712779 1097@dideu.com China 3989 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd +8613580539051 joe@yuhengpharm.com CHINA 21135 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2936 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Nanjing Chemlin Chemical Co., Ltd 64
EMMX Biotechnology LLC 60
Shanghai YuanYe Biotechnology Co., Ltd. 60
TargetMol Chemicals Inc. 58
Shaanxi Dideu Medichem Co. Ltd 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 58
Energy Chemical 58
TargetMol Chemicals Inc. 58
Shanghai Tachizaki Biomedical Research Center 58

View Lastest Price from SPIROXATRINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Spiroxatrine pictures 2026-08-30 Spiroxatrine
1054-88-2
 $80.00-263.00 99.94% 10g TargetMol Chemicals Inc.
SPIROXATRINE pictures 2025-12-24 SPIROXATRINE
1054-88-2
 1KG 98.0% 10 Shaanxi Dideu Medichem Co. Ltd
  • Spiroxatrine pictures
  • Spiroxatrine
    1054-88-2
  • $80.00-263.00
  • 99.94%
  • TargetMol Chemicals Inc.
  • SPIROXATRINE pictures
  • SPIROXATRINE
    1054-88-2
  • $0.10
  • 98.0%
  • Shaanxi Dideu Medichem Co. Ltd

SPIROXATRINE Spectrum

SPIROXATRINE(1054-88-2)1HNMR

1054-88-2(SPIROXATRINE)Related Search:

N-(2-Hydroxyethyl)-1,4-butanediamine 1,3-Propanediamine,N3,N3-dimethyl-1-phenyl- 3-PIPERIDINO-1,2-PROPANEDIOL SPIROXATRINE Isonipecotamide
Piperoxan 4-(DIETHYLAMINO)BUTYLAMINE (1-Methyl-4-piperidinyl)methanamine 2-Isopropoxyphenol 2-(2-Methoxyphenoxy)ethylamine
1-METHYLPIPERIDINE-4-CARBALDEHYDE 1,4-Benzodioxan 2-methyl-1,4-diaminobutane 2,3-Dihydro-1,4-benzodioxin-2-ylmethylamine N-(1-Methylpiperidin-4-yl)aniline
1,4-BENZODIOXAN-2-METHYLAMINE, N-METHYL- CHEMBRDG-BB 4009655 N-methyl-N-(3-phenoxypropyl)amine

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SPIROXATRINE R 5188 (+/-)-8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZA-SPIRO[4,5]DECAN-4-ONE 8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE SPIROXATRINE (R 5188) SELECTIVE SEROTONI N 5 R 5188, (±)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one Spiroxatrine (R 5188) 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl- 8-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 1054-88-2 Serotonin receptor