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SPIROXATRINE

SPIROXATRINE Structure
SPIROXATRINE structure
CAS No.
1054-88-2
Chemical Name:
SPIROXATRINE
Synonyms
R 5188;SPIROXATRINE;Spiroxatrine (R 5188);SPIROXATRINE (R 5188) SELECTIVE SEROTONI N 5;8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE;1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-;8-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;(+/-)-8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZA-SPIRO[4,5]DECAN-4-ONE;R 5188, (±)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one
CBNumber:
CB4157162
Molecular Formula:
C22H25N3O3
Molecular Weight:
379.45
MDL Number:
MFCD00055134
MOL File:
1054-88-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-11 19:39:08
Product description Number Pack Size Price
Spiroxatrine ≥98% 33415 5mg $87
Spiroxatrine ≥98% 33415 10mg $139
Spiroxatrine ≥98% 33415 25mg $283
Spiroxatrine ≥98% 33415 50mg $435
Spiroxatrine B6384 10mg $217
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SPIROXATRINE Properties

Melting point 215.8-218.0 °C
Boiling point 602.8±55.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
storage temp. Store at RT
solubility 0.1 M HCl: moderately soluble
form powder
pka 15.03±0.20(Predicted)
color white
FDA UNII DR0QR50ALL

SAFETY

Risk and Safety Statements

WGK Germany  3

SPIROXATRINE price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 33415 Spiroxatrine ≥98% 1054-88-2 5mg $87 2026-04-30 Buy
Cayman Chemical 33415 Spiroxatrine ≥98% 1054-88-2 10mg $139 2026-04-30 Buy
Cayman Chemical 33415 Spiroxatrine ≥98% 1054-88-2 25mg $283 2026-04-30 Buy
Cayman Chemical 33415 Spiroxatrine ≥98% 1054-88-2 50mg $435 2026-04-30 Buy
ApexBio Technology B6384 Spiroxatrine 1054-88-2 10mg $217 2026-05-06 Buy
Product number Packaging Price Buy
33415 5mg $87 Buy
33415 10mg $139 Buy
33415 25mg $283 Buy
33415 50mg $435 Buy
B6384 10mg $217 Buy

SPIROXATRINE Chemical Properties,Uses,Production

Uses

Spiroxatrine (R 5188) is a SR-1A antagonist.

Definition

ChEBI: 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one is a member of imidazolidines.

Biological Activity

5-HT 1A antagonist. More active and selective than spiperone. Also a very potent α 2C adrenergic receptor antagonist.

in vivo

Spiroxatrine (1-25 ug for i.p., 5 days) increases hindpaw withdrawal latencies to thermal and mechanical stimulation in the nerve injury rat and Carrageenan (HY-125474)-induced rat inflammation model[3].
Spiroxatrine (4 mg/kg/day for i.p., 5 mins) increases the voluntary oral ethanol intake induced by Fluoxetine (HY-B0102) in the selectively bred alcohol-preferring P line of rats [4].

Animal Model:The nerve injury rat model and Carrageenan (HY-125474)-induced rat inflammation model[3]
Dosage:1, 10, 25 ug, 5 days
Administration:Intraperitoneal injection (i.p.)
Result:Increased hindpaw withdrawal latencies to thermal and mechanical stimulation.
Animal Model:Fluoxetine (HY-B0102) -induced reduction of ethanol Intake by the P Line of rats[4]
Dosage:4 mg/kg/day, 5 mins
Administration:Intraperitoneal injection (i.p.)
Result:Increased the voluntary oral ethanol intake induced by Fluoxetine (HY-B0102) in the selectively bred alcohol-preferring P line of rats.

IC 50

α2-adrenergic receptor; 5-HT1A Receptor: 3.94 nM (Ki); 5-HT1B/D Receptor: 224000 nM (Ki); 5-HT2 Receptor: 118.5 nM (Ki)

SPIROXATRINE Preparation Products And Raw materials

Raw materials

Preparation Products

SPIROXATRINE Suppliers

Global( 50)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+8617392709771 1097@dideu.com China 3996 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15838 69
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13913916777 info@chemlin.com.cn China 16100 64
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 89686 60
BOC Sciences -- info@bocsci.com USA 0 65
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
TargetMol Chemicals Inc. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Aladdin Scientific 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Nanjing Chemlin Chemical Co., Ltd 64
EMMX Biotechnology LLC 60
Shanghai YuanYe Biotechnology Co., Ltd. 60
BOC Sciences 65

View Lastest Price from SPIROXATRINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Spiroxatrine pictures 2026-05-11 Spiroxatrine
1054-88-2
 US $80.00-263.00 / mg 99.94% 10g TargetMol Chemicals Inc.
SPIROXATRINE pictures 2025-12-24 SPIROXATRINE
1054-88-2
 US $0.10 / KG 1KG 98.0% 10 Shaanxi Dideu Medichem Co. Ltd
  • Spiroxatrine pictures
  • Spiroxatrine
    1054-88-2
  • US $80.00-263.00 / mg
  • 99.94%
  • TargetMol Chemicals Inc.
  • SPIROXATRINE pictures
  • SPIROXATRINE
    1054-88-2
  • US $0.10 / KG
  • 98.0%
  • Shaanxi Dideu Medichem Co. Ltd

SPIROXATRINE Spectrum

SPIROXATRINE(1054-88-2)1HNMR

1054-88-2(SPIROXATRINE)Related Search:

2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYLAMINE Piperoxan 4-(DIETHYLAMINO)BUTYLAMINE 2-Isopropoxyphenol 3-PIPERIDINO-1,2-PROPANEDIOL
N-(1-METHYLPIPERIDIN-4-YL)ANILINE SPIROXATRINE Isonipecotamide (1-Methyl-4-piperidinyl)methanamine 2-(2-Methoxyphenoxy)ethylamine
1,3-Propanediamine,N3,N3-dimethyl-1-phenyl- N-(2-Hydroxyethyl)-1,4-butanediamine 1-METHYLPIPERIDINE-4-CARBALDEHYDE 1,4-Benzodioxan 2-methyl-1,4-diaminobutane
1,4-BENZODIOXAN-2-METHYLAMINE, N-METHYL- CHEMBRDG-BB 4009655 1-[1-(2-METHOXYETHYL)PIPERIDIN-4-YL]METHANAMINE

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SPIROXATRINE R 5188 (+/-)-8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZA-SPIRO[4,5]DECAN-4-ONE 8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE SPIROXATRINE (R 5188) SELECTIVE SEROTONI N 5 R 5188, (±)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one Spiroxatrine (R 5188) 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl- 8-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 1054-88-2 Serotonin receptor