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ChemicalBook >> CAS DataBase List >>(+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid

(+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid

(+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid Structure
(+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid structure
CAS No.
88852-33-9
Chemical Name:
(+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid
Synonyms
(+/-)15-HEPE;WLKCSMCLEKGITB-XWJJKCKWSA-N;15-hydroxy-eicosa-5Z,8Z,11Z,13E,17Z-pentaenoic acid;(+/-)-15-Hydroxy-5Z,8Z,11Z,13E,17Z-eicosadienoic acid;(+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid;5,8,11,13,17-Eicosapentaenoic acid, 15-hydroxy-, (5Z,8Z,11Z,13E,17Z)-
CBNumber:
CB4160353
Molecular Formula:
C20H30O3
Molecular Weight:
318.45
MDL Number:
MFCD00216118
MOL File:
88852-33-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:28
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(+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid Properties

Boiling point 488.0±45.0 °C(Predicted)
Density 0.997±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
pka 4.75±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)
GHS02
Signal word  Danger
NFPA 704
3
0 0

(+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 32700 (±)15-HEPE ≥98% 88852-33-9 25μg $65 2026-04-30 Buy
Cayman Chemical 32700 (±)15-HEPE ≥98% 88852-33-9 50μg $124 2026-04-30 Buy
Cayman Chemical 32700 (±)15-HEPE ≥98% 88852-33-9 100μg $234 2026-04-30 Buy
Cayman Chemical 32700 (±)15-HEPE ≥98% 88852-33-9 250μg $520 2026-04-30 Buy
Cayman Chemical 32700 (±)15-HEPE ≥98% 88852-33-9 250 μg $760 2024-03-01 Buy
Product number Packaging Price Buy
32700 25μg $65 Buy
32700 50μg $124 Buy
32700 100μg $234 Buy
32700 250μg $520 Buy
32700 250 μg $760 Buy

(+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid Chemical Properties, Uses, Production

Description

(±)15-HEPE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEPE and 15(S)-HEPE . 15(S)-HEPE is formed from EPA via a 15(S)-HpEPE intermediate, which is produced by 15-lipoxygenase (15-LO) and reduced by glutathione peroxidase (GPX).1,2 (±)15-HEPE is active against P. acnes and S. aureus (MICs = 128 and 512 mg/L, respectively).3 It inhibits aggregation of isolated rat neutrophils induced by the formyl peptide receptor agonist fMLP (IC50 = 4.7 μM).4 Bronchoalveolar lavage fluid (BALF) levels of (±)15-HEPE are increased in patients with allergic asthma or COVID-19.5,6

Uses

(±)15-HEPE is an ester product.

Definition

ChEBI: 15-HEPE is a hydroxyicosapentaenoic acid that consists of 5Z,8Z,11Z,13E,17Z-eicosapentaenoic acid bearing an additional 15-hydroxy substituent. It has a role as a mouse metabolite. It is a HEPE and a hydroxy polyunsaturated fatty acid.

References

1. Miller, C., Yamaguchi, R.Y., and Ziboh, V.A. Guinea pig epidermis generates putative anti-inflammatory metabolites from fish oil polyunsaturated fatty acids Lipids 24(12),998-1003(1989).
2. Tan, L., Xin, X., Zhai, L., et al. Drosophila fed ARA and EPA yields eicosanoids, 15S-hydroxy-5Z,8Z, 11Z, 13E-eicosatetraenoic acid, and 15S-hydroxy-5Z,8Z,11Z,13E,17Z-eicosapentaenoic acid Lipids 51(4),435-449(2016).
3. Desbois, A.P., and Lawlor, K.C. Antibacterial activity of long-chain polyunsaturated fatty acids against Propionibacterium acnes and Staphylococcus aureus Mar. Drugs 11(11),4544-4557(2013).
4. Lam, B., Marcinkiewicz, E., and Wong, P.Y.-K. Transformation of 15-hydroperoxyeicosapentaenoic acid into mono- and dihydroxyeicosapentaenoic acids by human platelets Drugs affecting leukotrienes and other eicosanoid pathways ,167-180(1985).
5. Lundstrm, S.L., Yang, J., Kllberg, H.J., et al. Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation PLoS One 7(3),e33780(2012).
6. Archambault, A.-S., Zaid, Y., Rakotoarivelo, V., et al. High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients FASEB J. 35(6),e21666(2021).

(+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid Suppliers

Global Suppliers ( 39)
Supplier Tel Email Country ProdList Advantage
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
Yichang Zhongyitai Trading Co., Ltd. 0717-6449896 13886658719 root@zhongyitai.com China 1978 58
Alfa Chemistry 1-516-6625404 support@alfa-chemistry.com United States 9170 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8137 58
amyjet 4006800868;027-59626688 18771149750 sales@amyjet.com China 2909 58
Supplier Advantage
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Yichang Zhongyitai Trading Co., Ltd. 58
Alfa Chemistry 60
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Hongye Biotechnology Co. Ltd 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
amyjet 58

View Latest Price from (+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(±)15-HEPE pictures 2026-05-11 (±)15-HEPE
88852-33-9
 $535.00 10g TargetMol Chemicals Inc.

88852-33-9 ((+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid) Related Search:

15(S)-HEPE 15(S)-HPEPE 15(S)-Hpepe [1-14C] (+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid (+/-)5-HEPE
(+/-)-12-Hydroxy-5z,8z,10e,14z,17z-eicosapentaenoic acid

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(+/-)15-HEPE (+/-)-15-Hydroxy-5Z,8Z,11Z,13E,17Z-eicosadienoic acid WLKCSMCLEKGITB-XWJJKCKWSA-N 15-hydroxy-eicosa-5Z,8Z,11Z,13E,17Z-pentaenoic acid 5,8,11,13,17-Eicosapentaenoic acid, 15-hydroxy-, (5Z,8Z,11Z,13E,17Z)- (+/-)-15-Hydroxy-5z,8z,11z,13e,17z-eicosapentaenoic acid 88852-33-9