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SL 327

SL 327 structure

CAS No.: 305350-87-2

Chemical Name:: SL 327

Synonyms: SL 327;CS-1890;SL327【S4069】;SL 327; SL-327;SL 327 USP/EP/BP;MEK Inhibitor VII;SL327, 10 mM in DMSO;Mek-1/Mek-2 Inhibitor;SL 327, MEK inhibitor;MEK Inhibitor VII SL327 SL-327

CBNumber:: CB4168773

Molecular Formula:: C16H12F3N3S

Molecular Weight:: 335.35

MDL Number:: MFCD06411432

MOL File:: 305350-87-2.mol

MSDS File:: SDS

Last updated:2026-03-06 11:42:52

Product description	Number	Pack Size	Price
SL327 ≥98% (HPLC), Mixture of E & Z isomers, solid	S4069	5mg	$169.1
SL327 ≥98% (HPLC), Mixture of E & Z isomers, solid	S4069	25mg	$646
SL 327	L0331	5MG	$57
SL 327 [Optimized for Cell Culture]	L0470	1MG	$102
SL 327	L0331	25MG	$158
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SL 327 Properties

Melting point	127-128.2 °C
Boiling point	512.6±50.0 °C(Predicted)
Density	1.40
storage temp.	2-8°C
solubility	DMSO: 32 mg/mL
pka	3.42±0.10(Predicted)
form	solid
color	white
InChI	1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
InChIKey	JLOXTZFYJNCPIS-FYWRMAATSA-N
SMILES	N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
HS Code	2930909899
Storage Class	11 - Combustible Solids

SL 327 price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S4069	SL327 ≥98% (HPLC), Mixture of E & Z isomers, solid	305350-87-2	5mg	$169.1	2025-07-31	Buy
Sigma-Aldrich	S4069	SL327 ≥98% (HPLC), Mixture of E & Z isomers, solid	305350-87-2	25mg	$646	2025-07-31	Buy
TCI Chemical	L0331	SL 327	305350-87-2	5MG	$57	2025-07-31	Buy
TCI Chemical	L0470	SL 327 [Optimized for Cell Culture]	305350-87-2	1MG	$102	2025-07-31	Buy
TCI Chemical	L0331	SL 327	305350-87-2	25MG	$158	2025-07-31	Buy

Product number	Packaging	Price	Buy
S4069	5mg	$169.1	Buy
S4069	25mg	$646	Buy
L0331	5MG	$57	Buy
L0470	1MG	$102	Buy
L0331	25MG	$158	Buy

SL 327 Chemical Properties,Uses,Production

Description

The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC₅₀s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much higher concentrations (IC₅₀s = >50, 21, >100, >100, >10 μM, respectively). Since SL 327 rapidly passes the blood-brain barrier, it has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior, including long-term memory, spatial learning, and fear/operant conditioning.

Uses

SL-327 is a selective inhibitor of MEK1 and MEK2, and ERK1, MEK-3/p38, MEK-4, JNK, and PKC at higher concentrations.

Definition

ChEBI: A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4 aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2.

Biological Activity

Selective inhibitor of MEK1 and MEK2 (IC 50 values are 0.18 and 0.22 μ M respectively); blocks hippocampal LTP in vitro . Brain penetrant in vivo , blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

Biochem/physiol Actions

SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

storage

+4°C (desiccate)

References

[1] P A SCHERLE. Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy.[J]. The Journal of Biological Chemistry, 2000, 275 47: 37086-37092. DOI: 10.1074/jbc.m006168200
[2] STEFANIA FASANO R B. Ras-ERK Signaling in Behavior: Old Questions and New Perspectives.[J]. Frontiers in Behavioral Neuroscience, 2011, 5: 79. DOI: 10.3389/fnbeh.2011.00079

SL 327 Preparation Products And Raw materials

Raw materials

Preparation Products

SL 327 Suppliers

Global( 165)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32469	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	18843	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Shandong chuangyingchemical Co., Ltd.	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

View Lastest Price from SL 327 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-03-06	SL327 305350-87-2	US $31.00-64.00 / mg		99.94%	10g	TargetMol Chemicals Inc.
	2019-12-23	(Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile 305350-87-2	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

SL327
305350-87-2
US $31.00-64.00 / mg
99.94%
TargetMol Chemicals Inc.

(Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
305350-87-2
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

SL 327 Spectrum

SL 327(305350-87-2)MS SL 327(305350-87-2)¹HNMR

305350-87-2(SL 327)Related Search:

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BIX 02189 Benzeneacetonitrile 2-(TRIFLUOROMETHYL)PHENYLACETONITRILE SL 327

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ALPHA-[AMINO[(4-AMINOPHENYL)THIO]METHYLENE]-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE ALPHA-[AMINO-(4-AMINOPHENYLTHIO)METHYLENE)-2-(TRIFLUOROMETHYL)PHENYLACETONITRILE Mek-1/Mek-2 Inhibitor SL327;SL-327;MEK-1/MEK-2 INHIBITOR SL 327 Z-EPSILON-T E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE Z-AND E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE a-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile α-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile (2Z)-3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile MEK Inhibitor VII (Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile alpha-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile SL 327 SL 327 alpha-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile (Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile SL 327; SL-327 CS-1890 Benzeneacetonitrile, α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)- 3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile SL 327 USP/EP/BP MEK Inhibitor VII SL327 SL-327 Mitogen-activated protein kinase kinase,SL327,MEK,inhibit,Inhibitor,MAPKK,MAP2K SL 327, MEK inhibitor SL327, 10 mM in DMSO SL327【S4069】 305350-87-2 C16H12F3O3S Kinase/Phosphatase Biology Mitogen-Activated Protein Kinase Kinase (MAPKK) Serine/Threonine Kinase Inhibitors Cell Signaling and Neuroscience BioChemical Cell Biology Inhibitors Protein Kinase Signalling MAPK