PD 0325901
- CAS No.
- 391210-10-9
- Chemical Name:
- PD 0325901
- Synonyms
- Mirdametinib;PD325901;Mirdametinib (PD0325901);N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDE;CS-52;PD 032590;PD-0235901;PD 0325901;PD0325901, >=98%;MEK1/2 Inhibitor III
- CBNumber:
- CB42464161
- Molecular Formula:
- C16H14F3IN2O4
- Molecular Weight:
- 482.19
- MDL Number:
- MFCD08435926
- MOL File:
- 391210-10-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| InSolution? MEK1/2 Inhibitor III, PD0325901 | 444968 | 5mg | $253 |
| MEK1/2 Inhibitor III | 444966 | 5mg | $253 |
| PD 0325901 | P2897 | 10MG | $79 |
| PD 0325901 ≥90% | 13034 | 5mg | $54 |
| PD 0325901 ≥90% | 13034 | 10mg | $97 |
| More product size | |||
| Melting point | 112-114°C |
|---|---|
| Density | 1.817±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | White to off-white solid |
| pka | 13.45±0.20(Predicted) |
| color | white to off-white |
| optical activity | [α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChI | InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1 |
| InChIKey | SUDAHWBOROXANE-SECBINFHSA-N |
| SMILES | C(NOC[C@H](O)CO)(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F |
| FDA UNII | 86K0J5AK6M |
| NCI Drug Dictionary | mirdametinib |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H373-H413 | |||||||||
| Precautionary statements | P260-P264-P270-P273-P301+P310-P314 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 25-48-50 | |||||||||
| Safety Statements | 22-36/37/39-61 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| NFPA 704 |
|
PD 0325901 price More Price(116)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 444968 | InSolution? MEK1/2 Inhibitor III, PD0325901 | 391210-10-9 | 5mg | $253 | 2026-04-30 | Buy |
| Sigma-Aldrich | 444966 | MEK1/2 Inhibitor III | 391210-10-9 | 5mg | $253 | 2026-04-30 | Buy |
| TCI Chemical | P2897 | PD 0325901 | 391210-10-9 | 10MG | $79 | 2026-04-30 | Buy |
| Cayman Chemical | 13034 | PD 0325901 ≥90% | 391210-10-9 | 5mg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 13034 | PD 0325901 ≥90% | 391210-10-9 | 10mg | $97 | 2026-04-30 | Buy |
PD 0325901 Chemical Properties,Uses,Production
Description
PD 325901 (391210-10-9) is a selective non-ATP competitive MEK inhibitor (IC50 = 0.33 nM).1 Inhibits growth and/or proliferation of a variety of cancer cells.2 Enhances self-renewal of embryonic stem cells.3 In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells.4 In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells.5
Chemical Properties
White to Off-White Solid
Uses
PD 0325901 has been used as an inhibitor in extracellular signal-regulated kinase (ERK) inhibition assay in primed induced pluripotent stem cells, RKO colorectal cancer cell line and human embryonic stem cells(hESCs).
Uses
The mitogenic extracellular kinase 1/2 (MEK1/2) inhibitor
Definition
ChEBI: A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).
Biochem/physiol Actions
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.
storage
-20°C
Background
PD 0325901 is a potent and selective non-ATP competitive MEK inhibitor. This small molecule is highly effective at inhibiting cell growth and proliferation in various cancer cells. The potency of PD 0325901 has been illustrated by the inhibition of ERK phosphorylation in mouse and human cell models with an IC50 of 0.33 nM and between 20-50 nM, respectively. PD 0325901 increases the self-renewal of mouse embryonic stem cells by enhancing the expression of pluripotency genes and acts as an antagonist for retinoic acid induced cell differentiation.
References
[1] The biological profile of PD0325901: A second generation analog of CI-1040 with improved pharmaceutical potential
[2] LUDOVICA CIUFFREDA . Growth-Inhibitory and Antiangiogenic Activity of the MEK Inhibitor PD0325901 in Malignant Melanoma with or without BRAF Mutations[J]. Neoplasia, 2009, 11 8: Pages 720-731, W1-W6. DOI:10.1593/neo.09398
[3] ZHIYING AI. Maintenance of Self-Renewal and Pluripotency in J1 Mouse Embryonic Stem Cells through Regulating Transcription Factor and MicroRNA Expression Induced by PD0325901[J]. Stem Cells International, 2015, 2016 1. DOI:10.1155/2016/1792573
[4] CUIPING LI. MEK inhibitor PD0325901 and vitamin C synergistically induce hypomethylation of mouse embryonic stem cells.[J]. Oncotarget, 2016: 39730-39739. DOI:10.18632/oncotarget.9452
[5] WENLIN LI. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.[J]. Cell stem cell, 2009, 4 1: 16-19. DOI:10.1016/j.stem.2008.11.014
PD 0325901 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing jooe co., ltd | +undefined86-15223382610 | info@jooe.com | China | 15976 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28675 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Supplier | Advantage |
|---|---|
| Chongqing jooe co., ltd | 58 |
| Capot Chemical Co.,Ltd. | 60 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| career henan chemical co | 58 |
| Biochempartner | 58 |
| Alchem Pharmtech,Inc. | 58 |
| CONIER CHEM AND PHARMA LIMITED | 58 |
| TargetMol Chemicals Inc. | 58 |
| Dideu Industries Group Limited | 58 |
| BOC Sciences | 58 |
View Lastest Price from PD 0325901 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Mirdametinib
391210-10-9
|
$47.00-129.00 | 99.11% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-08-27 | PD 0325901
391210-10-9
|
$3.00 | 3KG | 98% | 1kg,5kg,100kg | Career Henan Chemical Co |
-
- Mirdametinib
391210-10-9
- $47.00-129.00
- 99.11%
- TargetMol Chemicals Inc.
-
- PD 0325901
391210-10-9
- $3.00
- 98%
- Career Henan Chemical Co
