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2-CHLORO-1,8-NAPHTHYRIDINE

2-CHLORO-1,8-NAPHTHYRIDINE structure

CAS No.: 15936-10-4

Chemical Name:: 2-CHLORO-1,8-NAPHTHYRIDINE

Synonyms: 2-CHLORO-1,8-NAPHTHYRIDINE;1,8-Naphthyridine, 2-chloro-

CBNumber:: CB4169679

Molecular Formula:: C8H5ClN2

Molecular Weight:: 164.59

MDL Number:: MFCD00234390

MOL File:: 15936-10-4.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:43

Product description	Number	Pack Size	Price
2-Chloro-1,8-naphthyridine	C384550	100mg	$200
2-Chloro-1,8-naphthyridine 96%	OR939109	250mg	$86
2-Chloro-1,8-naphthyridine 96%	3H32-5-VT	250mg	$138
2-Chloro-1,8-naphthyridine	8014AA	250mg	$190
2-CHLORO-1,8-NAPHTHYRIDINE 95.00%	HCH0118383	5MG	$496.12
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2-CHLORO-1,8-NAPHTHYRIDINE Properties

Melting point	138-139 °C
Boiling point	281.5±20.0 °C(Predicted)
Density	1.349±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	2.04±0.30(Predicted)
Appearance	Light yellow to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
HS Code	2933998090

2-CHLORO-1,8-NAPHTHYRIDINE price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C384550	2-Chloro-1,8-naphthyridine	15936-10-4	100mg	$200	2021-12-16	Buy
Apolloscientific	OR939109	2-Chloro-1,8-naphthyridine 96%	15936-10-4	250mg	$86	2021-12-16	Buy
SynQuest Laboratories	3H32-5-VT	2-Chloro-1,8-naphthyridine 96%	15936-10-4	250mg	$138	2021-12-16	Buy
AK Scientific	8014AA	2-Chloro-1,8-naphthyridine	15936-10-4	250mg	$190	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0118383	2-CHLORO-1,8-NAPHTHYRIDINE 95.00%	15936-10-4	5MG	$496.12	2021-12-16	Buy

Product number	Packaging	Price	Buy
C384550	100mg	$200	Buy
OR939109	250mg	$86	Buy
3H32-5-VT	250mg	$138	Buy
8014AA	250mg	$190	Buy
HCH0118383	5MG	$496.12	Buy

2-CHLORO-1,8-NAPHTHYRIDINE Chemical Properties,Uses,Production

Application

2-Chloro-1,8-Naphthidine has shown great activity in the design of novel antibiotics and drugs for the treatment of cardiovascular diseases, and is an important breakthrough for future drug development.

Synthesis

15936-09-1

15936-10-4

General procedure for the synthesis of 2-chloro-1,8-naphthyridine from 1,8-naphthyridin-2(1H)-one: Phosphoryl chloride (86 mL, 924 mmol) was added to 1,8-naphthyridin-2(1H)-one (9.00 g, 61.6 mmol), and the reaction mixture was heated to 100°C and maintained for 1 hour. Upon completion of the reaction, the mixture was cooled and the excess phosphorus trichloride was removed by evaporation. The residue was dissolved in dichloromethane (100 mL) and alkalized by slowly adding saturated sodium bicarbonate solution. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and the solvent evaporated to afford the target compound 2-chloro-1,8-naphthyridine as a white solid (7 g, 70% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.50 (1H, d, J=8.4 Hz), 7.52 (1H, dd, J=8.1 Hz and 4.3 Hz), 8.16 (1H, d, J=8.4 Hz), 8.22 (1H, dd, J=8.1 Hz and 2.0 Hz), 9.12 (1H, dd, J= 4.3 Hz and 2.0 Hz).

References

[1] Journal of the American Chemical Society, 2015, vol. 137, # 8, p. 2996 - 3003
[2] Patent: WO2005/47279, 2005, A1. Location in patent: Page/Page column 50
[3] Patent: WO2016/130968, 2016, A1. Location in patent: Page/Page column 161

2-CHLORO-1,8-NAPHTHYRIDINE Preparation Products And Raw materials

Raw materials

1,8-NAPHTHYRIDIN-2(8H)-ONE

Preparation Products

2-CHLORO-1,8-NAPHTHYRIDINE Suppliers

Global( 72)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Nanjing jinheyou Trading Co., Ltd.	15705188088	admin@jheyou.com	CHINA	1268	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30227	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49968	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58
Suzhou ARTK Medchem Co., Ltd.	+8618118463618	sales1@artkmedchem.com	China	39020	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39927	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Nanjing jinheyou Trading Co., Ltd.	58
Career Henan Chemica Co	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58
HANGZHOU LEAP CHEM CO., LTD.	58
Suzhou ARTK Medchem Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from 2-CHLORO-1,8-NAPHTHYRIDINE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-22	2-CHLORO-1,8-NAPHTHYRIDINE 15936-10-4	US $0.80-1.80 / KG	1KG	95%~99.99%	10 MT/ Month	Career Henan Chemica Co
	2019-12-31	2-CHLORO-1,8-NAPHTHYRIDINE 15936-10-4	US $0.00 / g	1g	95%min	20kg/month	Nanjing jinheyou Trading Co., Ltd.

2-CHLORO-1,8-NAPHTHYRIDINE
15936-10-4
US $0.80-1.80 / KG
95%~99.99%
Career Henan Chemica Co

2-CHLORO-1,8-NAPHTHYRIDINE
15936-10-4
US $0.00 / g
95%min
Nanjing jinheyou Trading Co., Ltd.

2-CHLORO-1,8-NAPHTHYRIDINE Spectrum

2-CHLORO-1,8-NAPHTHYRIDINE(15936-10-4)¹HNMR

15936-10-4(2-CHLORO-1,8-NAPHTHYRIDINE)Related Search:

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2-CHLORO-1,8-NAPHTHYRIDINE 1,8-Naphthyridine, 2-chloro- 15936-10-4