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2-Chloro-1,8-naphthyridine

2-Chloro-1,8-naphthyridine structure

CAS No.: 15936-10-4

Chemical Name:: 2-Chloro-1,8-naphthyridine

Synonyms: 2-Chloro-1,8-naphthyridine;1,8-Naphthyridine, 2-chloro-

CBNumber:: CB4169679

Molecular Formula:: C8H5ClN2

Molecular Weight:: 164.59

MDL Number:: MFCD00234390

MOL File:: 15936-10-4.mol

MSDS File:: SDS

Last updated:2026-09-12 18:52:29

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2-Chloro-1,8-naphthyridine Properties

Melting point	138-139 °C
Boiling point	281.5±20.0 °C(Predicted)
Density	1.349±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	2.04±0.30(Predicted)
Appearance	Light yellow to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
HS Code	2933998090

2-Chloro-1,8-naphthyridine price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	QAA93610	2-Chloro-1,8-naphthyridine	15936-10-4	2.5g	$531	2026-06-04	Buy
Apolloscientific	OR939109	2-Chloro-1,8-naphthyridine 96%	15936-10-4	250mg	$69	2026-06-04	Buy
Activate Scientific	AS45554	2-Chloro-1,8-naphthyridine 98%	15936-10-4	1g	$169	2026-06-04	Buy
Activate Scientific	AS45554	2-Chloro-1,8-naphthyridine 98%	15936-10-4	5g	$627	2026-06-04	Buy
Matrix Scientific	306760	2-Chloro-1,8-naphthyridine	15936-10-4	250.00mg	$36	2026-05-19	Buy

Product number	Packaging	Price	Buy
QAA93610	2.5g	$531	Buy
OR939109	250mg	$69	Buy
AS45554	1g	$169	Buy
AS45554	5g	$627	Buy
306760	250.00mg	$36	Buy

2-Chloro-1,8-naphthyridine Chemical Properties, Uses, Production

Application

2-Chloro-1,8-Naphthidine has shown great activity in the design of novel antibiotics and drugs for the treatment of cardiovascular diseases, and is an important breakthrough for future drug development.

Synthesis

15936-09-1

15936-10-4

General procedure for the synthesis of 2-chloro-1,8-naphthyridine from 1,8-naphthyridin-2(1H)-one: Phosphoryl chloride (86 mL, 924 mmol) was added to 1,8-naphthyridin-2(1H)-one (9.00 g, 61.6 mmol), and the reaction mixture was heated to 100°C and maintained for 1 hour. Upon completion of the reaction, the mixture was cooled and the excess phosphorus trichloride was removed by evaporation. The residue was dissolved in dichloromethane (100 mL) and alkalized by slowly adding saturated sodium bicarbonate solution. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and the solvent evaporated to afford the target compound 2-chloro-1,8-naphthyridine as a white solid (7 g, 70% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.50 (1H, d, J=8.4 Hz), 7.52 (1H, dd, J=8.1 Hz and 4.3 Hz), 8.16 (1H, d, J=8.4 Hz), 8.22 (1H, dd, J=8.1 Hz and 2.0 Hz), 9.12 (1H, dd, J= 4.3 Hz and 2.0 Hz).

References

[1] Journal of the American Chemical Society, 2015, vol. 137, # 8, p. 2996 - 3003
[2] Patent: WO2005/47279, 2005, A1. Location in patent: Page/Page column 50
[3] Patent: WO2016/130968, 2016, A1. Location in patent: Page/Page column 161

2-Chloro-1,8-naphthyridine Preparation Products And Raw materials

Raw materials

1,8-Naphthyridin-2(8H)-one

Preparation Products

2-Chloro-1,8-naphthyridine Suppliers

Global Suppliers ( 73)

Supplier	Tel	Email	Country	ProdList	Advantage
shanghai hechun co. ltd	021-021-64502386 18017349250	sale@syn-chem.cn	China	262	58
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Ennopharm Co., Ltd.	+86 (21) 6435-5022		China	4263	65
Hunan Hui Bai Shi Biotechnology Co., Ltd.	0731-85526065 13308475853	ivy@hnhbsj.com	China	7236	62
Beijing Yisiyan Technology Research Center	010-56645598 13366904824;	bjkaida@163.com	China	1596	59
Shanghai Hong-chuang Pharma Tech Co., Ltd.	18151128828	hc-sales@foxmail.com	China	2635	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Modachem Shanghai Co., Ltd	+86 (0)21 51320687 51371369 1744605818		China	1576	58
ShangHai AmK Pharmaceutical Technology Co., Ltd.	微信 18019252918 18019252918	sale@amkchem.com	China	14982	55
Cool Pharm, Ltd	021-60455363 18019463053	sales@coolpharm.com	China	8455	58

Supplier	Advantage
shanghai hechun co. ltd	58
Capot Chemical Co., Ltd	66
Shanghai Ennopharm Co., Ltd.	65
Hunan Hui Bai Shi Biotechnology Co., Ltd.	62
Beijing Yisiyan Technology Research Center	59
Shanghai Hong-chuang Pharma Tech Co., Ltd.	55
Bide Pharmatech Ltd.	60
Modachem Shanghai Co., Ltd	58
ShangHai AmK Pharmaceutical Technology Co., Ltd.	55
Cool Pharm, Ltd	58

View Latest Price from 2-Chloro-1,8-naphthyridine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-22	2-CHLORO-1,8-NAPHTHYRIDINE 15936-10-4	$1.80	1KG	95%~99.99%	10 MT/ Month	Career Henan Chemica Co
	2019-12-31	2-CHLORO-1,8-NAPHTHYRIDINE 15936-10-4		1g	95%min	20kg/month	Nanjing jinheyou Trading Co., Ltd.

2-CHLORO-1,8-NAPHTHYRIDINE
15936-10-4
$1.80
95%~99.99%
Career Henan Chemica Co

2-CHLORO-1,8-NAPHTHYRIDINE
15936-10-4
$0.00
95%min
Nanjing jinheyou Trading Co., Ltd.

2-Chloro-1,8-naphthyridine Spectrum

2-CHLORO-1,8-NAPHTHYRIDINE(15936-10-4)¹HNMR

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1,8-Naphthyridine, 2-chloro- 2-Chloro-1,8-naphthyridine 15936-10-4