1-(3-Chloro-2-hydroxyphenyl)ethan-1-one
- CAS No.
- 3226-34-4
- Chemical Name:
- 1-(3-Chloro-2-hydroxyphenyl)ethan-1-one
- Synonyms
- ASISCHEM D38763;2-HYDROXY-3-CHLOROACETOPHENONE;3'-Chloro-2'-hydroxyacetophenone;3'- Chloro -2'- hydroxy acetophenone;1-(3-Chloro-2-hydroxyphenyl)ethanone;1-(3-Chloro-2-hydroxyphenyl)ethan-1-one;Ethanone, 1-(3-chloro-2-hydroxyphenyl)-;1-(3-Chloro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-6-chlorophenol
- CBNumber:
- CB4176631
- Molecular Formula:
- C8H7ClO2
- Molecular Weight:
- 170.59
- MDL Number:
- MFCD00100492
- MOL File:
- 3226-34-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 80 °C |
|---|---|
| Boiling point | 87-89 °C(Press: 1 Torr) |
| Density | 1.298±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Dichloromethane, Ethyl Acetate, Methanol |
| form | Solid |
| pka | 8.69±0.10(Predicted) |
| color | Yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| HS Code | 2914790090 | |||||||||
| NFPA 704 |
|
1-(3-Chloro-2-hydroxyphenyl)ethan-1-one price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-H825100-500MG | 2’-Hydroxy-3-chloroacetophenone | 3226-34-4 | 500mg | $129 | 2026-06-03 | Buy |
| TRC | TRC-H825100-2G | 2’-Hydroxy-3-chloroacetophenone | 3226-34-4 | 2g | $294 | 2026-06-03 | Buy |
| TRC | TRC-H825100-1G | 2’-Hydroxy-3-chloroacetophenone | 3226-34-4 | 1g | $154 | 2026-06-03 | Buy |
| Activate Scientific | AS38553 | 1-(3-Chloro-2-hydroxyphenyl)ethanone 98% | 3226-34-4 | 1g | $96 | 2026-06-04 | Buy |
| Activate Scientific | AS38553 | 1-(3-Chloro-2-hydroxyphenyl)ethanone 98% | 3226-34-4 | 5g | $289 | 2026-06-04 | Buy |
1-(3-Chloro-2-hydroxyphenyl)ethan-1-one Chemical Properties, Uses, Production
Chemical Properties
Yellow Solid
Uses
2’-Hydroxy-3-chloroacetophenone (cas# 3226-34-4) is a compound useful in organic synthesis.
Definition
ChEBI: 1-(3-Chloro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone.
Preparation
Preparation by Fries rearrangement of 2-chlorophenyl acetate with aluminium chloride,
without solvent, between 110° and 180° (40–21%)
in tetrachloroethane at 70–80°.
Synthesis
4525-75-1
3226-34-4
2892-29-7
General procedure for the synthesis of 1-(3-chloro-2-hydroxyphenyl)ethan-1-one and 1-(3-chloro-4-hydroxyphenyl)ethanone from 2-chlorophenol acetic acid: 2-chlorophenol acetic acid (152.5 g, 893.7 mmol) was slowly added dropwise to a solution of dichlorobenzene (120 mL) containing aluminum chloride (119.0 g, 893.7 mmol) at room temperature. The reaction mixture was stirred continuously at 100 °C for 5 hours. Upon completion of the reaction, it was cooled to room temperature and diluted with the addition of dichloromethane, after which the mixture was slowly poured into a 2N sulfuric acid solution at 0°C. The precipitated 3-chloro-4-hydroxyacetophenone was removed by filtration. The aqueous layer was separated and extracted with dichloromethane. All organic phases were combined, washed sequentially with water, dried and concentrated. The residue was recrystallized by cyclohexane to give additional 3-chloro-4-hydroxyacetophenone (23.6 g) as a pale yellow solid. By concentrating the crystallized mother liquor, 47.3 g (31.0% yield) of the target product 1-(3-chloro-2-hydroxyphenyl)ethan-1-one was obtained as a yellow oil.1H NMR (CDCl3) δ 12.84 (broad single peak, 1H, exchangeable with D2O), 7.67 (double-double peak, 1H), 7.57 (double-double peak, 1H), 6.87 (double-double peak, 1H), 6.87 (double-double peak, 1H), 6.87 (double-double peak, 1H), 6.87 (double-double peak, 1H), 6.87 (double-double peak, 1H), 6.87 (double-double peak, 1H). 1H), 2.66 (single peak, 3H).The melting point of 3-chloro-4-hydroxyacetophenone was 109 °C; 1H NMR (CDCl3) δ 7.98 (double peak, 1H), 7.81 (multiple peaks, 1H), 7.08 (multiple peaks, 1H), 6.30 (broad single peak, 1H, exchangeable with D2O), 2.56 (single peak, 3H).
References
[1] European Journal of Medicinal Chemistry, 2012, vol. 58, p. 184 - 191
[2] Journal of the Indian Chemical Society, 1959, vol. 36, p. 784
[3] Journal of Chemical Research, Miniprint, 1989, # 11, p. 2713 - 2739
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 1, p. 132 - 140
1-(3-Chloro-2-hydroxyphenyl)ethan-1-one Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13323 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
View Latest Price from 1-(3-Chloro-2-hydroxyphenyl)ethan-1-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-07-11 | 1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE
3226-34-4
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE
3226-34-4
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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