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1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE

1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE structure

CAS No.: 3226-34-4

Chemical Name:: 1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE

Synonyms: ASISCHEM D38763;2-HYDROXY-3-CHLOROACETOPHENONE;3'-Chloro-2'-hydroxyacetophenone;1-(3-Chloro-2-hydroxyphenyl)ethanone;3'- Chloro -2'- hydroxy acetophenone;Ethanone, 1-(3-chloro-2-hydroxyphenyl)-;1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE;1-(3-Chloro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-6-chlorophenol

CBNumber:: CB4176631

Molecular Formula:: C8H7ClO2

Molecular Weight:: 170.59

MDL Number:: MFCD00100492

MOL File:: 3226-34-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:54:09

Product description	Number	Pack Size	Price
2’-Hydroxy-3-chloroacetophenone	TRC-H825100-500MG	500mg	$129
2’-Hydroxy-3-chloroacetophenone	TRC-H825100-2G	2g	$294
2’-Hydroxy-3-chloroacetophenone	TRC-H825100-1G	1g	$154
1-(3-Chloro-2-hydroxyphenyl)ethanone 98%	AS38553	1g	$96
1-(3-Chloro-2-hydroxyphenyl)ethanone 98%	AS38553	5g	$289
More product size

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1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE Properties

Melting point	80 °C
Boiling point	87-89 °C(Press: 1 Torr)
Density	1.298±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Dichloromethane, Ethyl Acetate, Methanol
form	Solid
pka	8.69±0.10(Predicted)
color	Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Hazard Codes

HS Code

2914790090

NFPA 704

	1
2		0

1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE price More Price(50)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-H825100-500MG	2’-Hydroxy-3-chloroacetophenone	3226-34-4	500mg	$129	2026-06-03	Buy
TRC	TRC-H825100-2G	2’-Hydroxy-3-chloroacetophenone	3226-34-4	2g	$294	2026-06-03	Buy
TRC	TRC-H825100-1G	2’-Hydroxy-3-chloroacetophenone	3226-34-4	1g	$154	2026-06-03	Buy
Activate Scientific	AS38553	1-(3-Chloro-2-hydroxyphenyl)ethanone 98%	3226-34-4	1g	$96	2026-06-04	Buy
Activate Scientific	AS38553	1-(3-Chloro-2-hydroxyphenyl)ethanone 98%	3226-34-4	5g	$289	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-H825100-500MG	500mg	$129	Buy
TRC-H825100-2G	2g	$294	Buy
TRC-H825100-1G	1g	$154	Buy
AS38553	1g	$96	Buy
AS38553	5g	$289	Buy

1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

2’-Hydroxy-3-chloroacetophenone (cas# 3226-34-4) is a compound useful in organic synthesis.

Definition

ChEBI: 1-(3-Chloro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone.

Preparation

Preparation by Fries rearrangement of 2-chlorophenyl acetate with aluminium chloride,
without solvent, between 110° and 180° (40–21%)
in tetrachloroethane at 70–80°.

Synthesis

4525-75-1

3226-34-4

2892-29-7

General procedure for the synthesis of 1-(3-chloro-2-hydroxyphenyl)ethan-1-one and 1-(3-chloro-4-hydroxyphenyl)ethanone from 2-chlorophenol acetic acid: 2-chlorophenol acetic acid (152.5 g, 893.7 mmol) was slowly added dropwise to a solution of dichlorobenzene (120 mL) containing aluminum chloride (119.0 g, 893.7 mmol) at room temperature. The reaction mixture was stirred continuously at 100 °C for 5 hours. Upon completion of the reaction, it was cooled to room temperature and diluted with the addition of dichloromethane, after which the mixture was slowly poured into a 2N sulfuric acid solution at 0°C. The precipitated 3-chloro-4-hydroxyacetophenone was removed by filtration. The aqueous layer was separated and extracted with dichloromethane. All organic phases were combined, washed sequentially with water, dried and concentrated. The residue was recrystallized by cyclohexane to give additional 3-chloro-4-hydroxyacetophenone (23.6 g) as a pale yellow solid. By concentrating the crystallized mother liquor, 47.3 g (31.0% yield) of the target product 1-(3-chloro-2-hydroxyphenyl)ethan-1-one was obtained as a yellow oil.1H NMR (CDCl3) δ 12.84 (broad single peak, 1H, exchangeable with D2O), 7.67 (double-double peak, 1H), 7.57 (double-double peak, 1H), 6.87 (double-double peak, 1H), 6.87 (double-double peak, 1H), 6.87 (double-double peak, 1H), 6.87 (double-double peak, 1H), 6.87 (double-double peak, 1H), 6.87 (double-double peak, 1H). 1H), 2.66 (single peak, 3H).The melting point of 3-chloro-4-hydroxyacetophenone was 109 °C; 1H NMR (CDCl3) δ 7.98 (double peak, 1H), 7.81 (multiple peaks, 1H), 7.08 (multiple peaks, 1H), 6.30 (broad single peak, 1H, exchangeable with D2O), 2.56 (single peak, 3H).

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 58, p. 184 - 191
[2] Journal of the Indian Chemical Society, 1959, vol. 36, p. 784
[3] Journal of Chemical Research, Miniprint, 1989, # 11, p. 2713 - 2739
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 1, p. 132 - 140

1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE Preparation Products And Raw materials

Raw materials

2-CHLOROPHENYL ACETATE 1-(3-CHLORO-4-HYDROXYPHENYL)-1-ETHANONE 3'-Chloroacetophenone 2-Chlorophenol Aluminum chloride

1,2-Dichlorobenzene

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Preparation Products

1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE Suppliers

Global( 97)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-173 9270 1263	1057@dideu.com	China	3957	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30224	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34563	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14303	58
Changzhou Anxuan Chemical Co., Ltd	+86-0519-89882563 +86-18961279162	andy@anxuanchem.com	China	4327	58
Labnetwork lnc.	+86-27-50766799 +86-18062016861	contact@labnetwork.com	China	19987	58
Aromsyn Co., Ltd.	+86-0571-85585865 +86-13336024896	CB@aromsyn.com	China	19183	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Changzhou Ansciep Chemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58
Changzhou Anxuan Chemical Co., Ltd	58
Labnetwork lnc.	58
Aromsyn Co., Ltd.	58

View Lastest Price from 1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-07-11	1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE 3226-34-4	$1.00	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd

1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE
3226-34-4
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE Spectrum

1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE(3226-34-4)¹HNMR

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1-(3-Chloro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-6-chlorophenol ASISCHEM D38763 1-(3-CHLORO-2-HYDROXYPHENYL)ETHAN-1-ONE 2-HYDROXY-3-CHLOROACETOPHENONE 3'-Chloro-2'-hydroxyacetophenone 1-(3-Chloro-2-hydroxyphenyl)ethanone Ethanone, 1-(3-chloro-2-hydroxyphenyl)- 3'- Chloro -2'- hydroxy acetophenone 3226-34-4 Aromatics