M40
- CAS No.
- 143896-17-7
- Chemical Name:
- M40
- Synonyms
- M40;CDCBM6;CSCSC1;MGC16435;M40（TFA）;MGC117247;M40?, >98%;OK/SW-cl.56;GWTLNSAGYLLGPPPALALA-NH2;Tubulin, GST tagged human
- CBNumber:
- CB4190842
- Molecular Formula:
- C94H145N23O24
- Molecular Weight:
- 1981.3
- MDL Number:
- MFCD00671424
- MOL File:
- 143896-17-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Tubulin, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | SRP5148 | 20 μg | $354 |
| Tubulin, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | SRP5148 | 20μG | $345 |
| M40 | 3425 | 1 | $227 |
| M40 | 255744 | 1mg | $480 |
| GALANIN RECEPTOR LIGAND M40 95.00% | PEP0001397 | 1MG | $721.59 |
| storage temp. | −20°C |
|---|---|
| form | Powder |
| color | White to off-white |
| biological source | human |
| Water Solubility | Soluble to 1 mg/ml in water |
| Sequence | Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2 |
| FDA UNII | HSN8WK37D7 |
| UNSPSC Code | 12352202 |
| NACRES | NA.32 |
M40 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP5148 | Tubulin, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 1622402-26-9 | 20 μg | $354 | 2025-07-31 | Buy |
| Sigma-Aldrich | SRP5148 | Tubulin, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 1622402-26-9 | 20μG | $345 | 2024-03-01 | Buy |
| Tocris | 3425 | M40 | 143896-17-7 | 1 | $227 | 2021-12-16 | Buy |
| Usbiological | 255744 | M40 | 143896-17-7 | 1mg | $480 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0001397 | GALANIN RECEPTOR LIGAND M40 95.00% | 143896-17-7 | 1MG | $721.59 | 2021-12-16 | Buy |
M40 Chemical Properties,Uses,Production
Uses
GST tagged tubulin has been used in Western blotting and in mass spec as a control.
Biological Activity
Tubulin-β 1 (TUBB1) interaction with microtubule-associated proteins (MAPs) such as tau is fundamental for microtubule structure and function. It has a role in the formation of the cytoskeleton. Studies revealed th at TUBB1 is the target of various antitubulin agents used in the treatment of cancer. Subsequent studies have also concluded th at TUBB1 mutations in clinical samples are rare, and unlikely to contribute to drug resistance.
in vivo
M40 (0.1-1 nmol, intracisternal injection, single dose) blocks selectively the central cardiovascular responses induced by galanin-(1–15) in Sprague-Dawley rats models, according to the recognization of galanin receptor in N-terminus[1].
M40 (2-8 nmol, intraventricular or intrahippocampal, single dose) exhibits antagonist efficacy against galanin on memory tasks in sprague-dawley rats models, exhibits potency in alleviating the cognitive deficits associated with Alzheimer's disease[2].
| Animal Model: | Vasopressor and tachycardia induced by galanin in Sprague-Dawley rats[1] |
| Dosage: | 0.1-1 nmol |
| Administration: | Intracisternal injection, single dose |
| Result: | Blocked the feeding effects of galanin in the hypothalamus and amygdala. Reduced vasopressor response and heart rate induced by galanin-(1-15), but not those effects induced by galanin-(1-29). |
| Animal Model: | Memory impairment induced by galanin in rats model[2] |
| Dosage: | 2-8 nmol |
| Administration: | intraventricular or intrahippocampal, single dose |
| Result: | Blocked the impairment in choice accuracy. |
storage
Store at -20°C
M40 Preparation Products And Raw materials
Raw materials
Preparation Products
M40 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 995 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 | sales1@gotopbio.com | CHINA | 2609 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| Nanjing TGpeptide | +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5218 | 58 |
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
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