Galanin (2-11) porcine, rat
- CAS No.
- 367518-31-8
- Chemical Name:
- Galanin (2-11) porcine, rat
- Synonyms
- AR-M 1896;GALANIN (2-11);Galanin (2-11) (AR-M 1896);Galanin (2-11) porcine, rat;TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2;H-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2;L-Leucinamide, L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-
- CBNumber:
- CB1205136
- Molecular Formula:
- C54H81N13O14
- Molecular Weight:
- 1136.3
- MDL Number:
- MFCD05664726
- MOL File:
- 367518-31-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 1595.4±65.0 °C(Predicted) |
|---|---|
| Density | 1.291±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Soluble to 1 mg/ml in 20% formic acid |
| form | lyophilized powder |
| pka | 9.82±0.15(Predicted) |
| biological source | synthetic |
| Sequence | Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-NH2 |
| InChIKey | SUJPPMXJCZETOA-ZKEPBWIVSA-N |
| UNSPSC Code | 12352209 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
Galanin (2-11) porcine, rat price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G8293 | Galanin (2-11) porcine, rat ≥97% (HPLC), lyophilized powder | 367518-31-8 | 500μG | $580 | 2025-07-31 | Buy |
| Usbiological | 254662 | AR-M 1896 Asreported | 367518-31-8 | 1mg | $602 | 2026-06-03 | Buy |
| Biosynth | FG110166 | Galanin (2-11) amide trifluoroacetate salt | 367518-31-8 | 5mg | $900 | 2026-06-04 | Buy |
| Biosynth | FG110166 | Galanin (2-11) amide trifluoroacetate salt | 367518-31-8 | 2mg | $900 | 2026-06-04 | Buy |
| Biosynth | FG110166 | Galanin (2-11) amide trifluoroacetate salt | 367518-31-8 | 1mg | $900 | 2026-06-04 | Buy |
Galanin (2-11) porcine, rat Chemical Properties, Uses, Production
Uses
AR-M1896 is a GalR2 selective agonist with a binding IC50 of 1.76 nM for rat GalR2. AR-M1896 can be used for the research of acute myocardial infarction and neuropathic pain[1][2].
Biological Activity
binding ic50: 1.76 nm for rgalr2; 879 nm for hgalr1galanin is a 29-aa neuropeptide with a complex role in pain processing. galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution. three galanin receptors, galr1, galr2 and galr3, have been identified and cloned. ar-m1896 is a specific galanin r2 (galr2) agonist.
in vitro
additional removal of the glycine residue in position 1 resulted in ar-m1896 with almost unchanged galr2 affinity and functional activity, and 500-fold selectivity for galr2-rs over galr1-rs. this compound represents a truly galr2-selective galanin analog and, thus, could be used as a pharmacological tool to differentiate between these two receptors [1].
in vivo
in normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. the same effect is seen with equimolar doses of ar-m1896 or ar-m961 (an agonist both at galr1 and galr2 receptors). in allodynic bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high ar-m961dose, whereas no effect was observed in the control or ar-m1896 group. no effect of either compounds was observed in nonallodynic bennett model rats [1].
References
[1] liu hx, brumovsky p, schmidt r, brown w, payza k, hodzic l, pou c, godbout c, hökfelt t. receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via galr1 and galr2 receptors. proc natl acad sci u s a. 2001 aug 14;98(17):9960-4.
Galanin (2-11) porcine, rat Preparation Products And Raw materials
Raw materials
Preparation Products
Galanin (2-11) porcine, rat Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4725 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
View Latest Price from Galanin (2-11) porcine, rat manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-23 | Galanin (2-11)
367518-31-8
|
$1.00 | 1g | Min98% HPLC | Career Henan Chemical Co |
-
- Galanin (2-11)
367518-31-8
- $1.00
- Min98% HPLC
- Career Henan Chemical Co
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