4-(4-Nitrobenzyl)piperazine-1-carboxylic acid tert-butyl ester
- CAS No.
- 130636-61-2
- Chemical Name:
- 4-(4-Nitrobenzyl)piperazine-1-carboxylic acid tert-butyl ester
- Synonyms
- BUTTPARK 36\08-67;1-Boc-4-(4-nitrobenzyl)piperazine;N2-{[(2-Methyl-2-Propanyl)Oxy]Carbonyl}-L-Glutamine;1-[(4-nitrophenyl)methyl]-4-tert-butyloxycarbonylpiperazine;tert-butyl 4-[(4-nitrophenyl)Methyl]piperazine-1-carboxylate;4-(4-Nitrobenzyl)piperazine-1-carboxylic acid tert-butyl ester;4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%;4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylic acid tert-butyl ester;tert-butyl 4-[(4-nitrophenyl)methyl]piperazine-1-carboxylate - [AC77724];4-[(4-NITROPHENYL)METHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
- CBNumber:
- CB4199461
- Molecular Formula:
- C16H23N3O4
- Molecular Weight:
- 321.37
- MDL Number:
- MFCD03407491
- MOL File:
- 130636-61-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-(4-Nitrobenzyl)piperazine-1-carboxylic acid tert-butyl ester price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 071894 | 1-Boc-4-(4-Nitrobenzyl)piperazine | 130636-61-2 | 1.00g | $278 | 2026-05-18 | Buy |
| Matrix Scientific | 071894 | 1-Boc-4-(4-Nitrobenzyl)piperazine | 130636-61-2 | 5.00g | $759 | 2026-05-18 | Buy |
| Matrix Scientific | 071894 | 1-Boc-4-(4-Nitrobenzyl)piperazine | 130636-61-2 | 10.00g | $1071 | 2026-05-18 | Buy |
| Synthonix | AC77724 | tert-butyl 4-[(4-nitrophenyl)methyl]piperazine-1-carboxylate 99% | 130636-61-2 | 1g | $31.59 | 2026-05-06 | Buy |
| Synthonix | AC77724 | tert-butyl 4-[(4-nitrophenyl)methyl]piperazine-1-carboxylate 99% | 130636-61-2 | 5g | $121.5 | 2026-05-06 | Buy |
4-(4-Nitrobenzyl)piperazine-1-carboxylic acid tert-butyl ester Chemical Properties, Uses, Production
Synthesis
100-11-8
57260-71-6
130636-61-2
General procedure for the synthesis of tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate from 4-nitrobenzyl bromide and N-BOC-piperazine: Potassium carbonate (3 g) was added to a solution containing tert-butyl 1-piperazinecarboxylate (0.74 g, 4 mmol) and 4-nitrobenzyl bromide (0.86 g, 4 mmol) in N,N-dimethylformamide (DMF, 5 mL). The reaction mixture was stirred at room temperature for 4 hours. After the reaction was completed, the product was extracted with ethyl acetate (50 mL) and the organic phase was washed with water (20 mL x 3). The organic layer was dried with anhydrous sodium sulfate and subsequently concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography using ethyl acetate as eluent to afford the target compound tert-butyl 4-(4-nitrobenzyl)-1-piperazinecarboxylate (3) (1.22 g, 95% yield) with a melting point of 99-100 °C. 1H NMR (DMSO-d6) data were as follows: δ 8.21-8.19 (d, 2H, J = 8.8 Hz, Ar-H), 7.61 -7.59 (d, 2H, J = 8.0 Hz, Ar-H), 3.63 (s, 2H, CH2), 3.34-3.30 (m, 4H, partially fuzzy, 2 × CH2), 2.35-2.32 (m, 4H, 2 × CH2), 1.39 (s, 9H, 3 × CH3). Elemental analysis (C16H23N3O4) results are consistent with calculated values.
References
[1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 19, p. 5592 - 5599
[2] Patent: US2004/34033, 2004, A1. Location in patent: Page/Page column 12; Sheet 1
[3] Patent: US2007/249649, 2007, A1. Location in patent: Page/Page column 116
[4] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 120
[5] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 122
4-(4-Nitrobenzyl)piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4555 | 58 |
| Shanghai Kahn Pharmaceutical Co., Ltd. | 021-34979681; 17701870669 | 41513101@qq.com | China | 1785 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Chengdu Xiaojia Technology Co., Ltd. | 15902830537 | zhanghao@happysyn.com | China | 2361 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Latest Price from 4-(4-Nitrobenzyl)piperazine-1-carboxylic acid tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-14 | 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
130636-61-2
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
130636-61-2
- $9.80
- ≥99%
- Career Henan Chemical Co
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