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Ethyl 5-chloro-methyl pyrazole-4-carboxylate

Ethyl 5-chloro-methyl pyrazole-4-carboxylate Structure
Ethyl 5-chloro-methyl pyrazole-4-carboxylate structure
CAS No.
56984-32-8
Chemical Name:
Ethyl 5-chloro-methyl pyrazole-4-carboxylate
Synonyms
Ethyl 5-(chloromethyl)-1H-pyrazole-4-carboxylate;Ethyl 5-chloropyrazole-4-carboxylate;Ethyl 5-chloro-methyl pyrazole-4-carboxylate;ETHYL-5-CHLORO-1-METHYLPYRAZOLE-4-CARBOXYLATE;1H-Pyrazole-4-carboxylic acid, 5-chloro-1-methyl-, ethyl ester
CBNumber:
CB4206149
Molecular Formula:
C7H9ClN2O2
Molecular Weight:
188.61
MDL Number:
MFCD03411879
MOL File:
56984-32-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:33
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Ethyl 5-chloro-methyl pyrazole-4-carboxylate Properties

Boiling point 80-82 °C(Press: 0.2 Torr)
Density 1.31±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -1.13±0.10(Predicted)
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H332-H315-H319-H312-H335-H302
Precautionary statements  P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
HS Code  2933199090

Ethyl 5-chloro-methyl pyrazole-4-carboxylate price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR958537 Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate 95% 56984-32-8 250mg $21 2026-06-04 Buy
Apolloscientific OR958537 Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate 95% 56984-32-8 1g $41 2026-06-04 Buy
Apolloscientific OR958537 Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate 95% 56984-32-8 5g $137 2026-06-04 Buy
Synthonix E46318 Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate 95+% 56984-32-8 1g $43 2026-05-06 Buy
Synthonix E46318 Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate 95+% 56984-32-8 5g $70 2026-05-06 Buy
Product number Packaging Price Buy
OR958537 250mg $21 Buy
OR958537 1g $41 Buy
OR958537 5g $137 Buy
E46318 1g $43 Buy
E46318 5g $70 Buy

Ethyl 5-chloro-methyl pyrazole-4-carboxylate Chemical Properties, Uses, Production

Synthesis

ETHYL 5-AMINO-1-METHYLPYRAZOLE-4-CARBOXYLATE

31037-02-2

ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE

56984-32-8

General procedure for the synthesis of 5-chloro-4-ethoxycarbonyl-1-methylpyrazole from ethyl 5-amino-1-methylpyrazole-4-carboxylate: cuprous chloride (CuCl, 1.76 g, 1.77 mmol) was added to a solution of tert-butyl nitrite (tBuONO, 2.95 mL, 2.46 mmol) in acetonitrile (ACN), followed by the addition of 5-amino-1 -methylpyrazole-4-carboxylic acid ethyl ester (2.5 g, 1.48 mmol). The reaction mixture was stirred at room temperature for 2 h and then heated at 60 °C for 1 h. The reaction was carried out by thin layer chromatography (TLC). The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature, diluted with 2N aqueous hydrochloric acid and extracted with hydrochloric acid (3×). The combined organic phases were washed with brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated, and finally purified by fast column chromatography to afford the target product 5-chloro-4-ethoxycarbonyl-1-methylpyrazole (2.08 g, 75% yield). The structure of the product was confirmed by 1H-NMR (300 MHz, CDCl3) with chemical shifts δ: 7.90 (1H, s), 4.30 (2H, q, J = 5.4 Hz), 3.86 (3H, s), 1.34 (3H, t, J = 5.4 Hz).

References

[1] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 4, p. 326 - 339
[2] Patent: CN105164112, 2017, B. Location in patent: Paragraph 0439-0442
[3] Patent: US2007/225280, 2007, A1. Location in patent: Page/Page column 18
[4] Patent: US4872901, 1989, A
[5] Patent: US4620865, 1986, A

Ethyl 5-chloro-methyl pyrazole-4-carboxylate Preparation Products And Raw materials

Raw materials

Ethyl 5-amino-1-methylpyrazole-4-carboxylate Acetonitrile Copper(I) chloride tert-Butyl nitrite

Preparation Products

Ethyl 5-chloro-methyl pyrazole-4-carboxylate Suppliers

Global Suppliers ( 70)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Acorn PharmaTech Co., Ltd. 025-58395930 sales@acornpharma.com China 982 60
Shanghai Xingui Biotechnology Co., Ltd. 15121041756 xingui2022@126.com China 9954 58
Nanjing YiFan Biological Technology Co., Ltd. 025-025-52700520 18914499889 sales@yfbiotech.com China 494 58
Shanghai Yongye Biotechnology Co., Ltd. 86-021-61559134 15921386130 3423497944@qq.com China 8135 55
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Hubei Jusheng Technology Co.,Ltd 027-59599241 18871490274 1400878000@qq.com China 9506 58
Nanjing Asia Pharmaceutical Technology Co., Ltd. +86-15251749953 pl_pharmatech@163.com China 82 55
SuZhou ShiYa Biopharmaceuticals, Inc. 0512-0512-52358471 17715136450 sales@shiyabiopharm.com China 9814 58
Yancheng KangdiSen Pharmaceutical Co., Ltd. 13812573443;18052965989 tongbenwan22@163.com China 1975 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Acorn PharmaTech Co., Ltd. 60
Shanghai Xingui Biotechnology Co., Ltd. 58
Nanjing YiFan Biological Technology Co., Ltd. 58
Shanghai Yongye Biotechnology Co., Ltd. 55
Cool Pharm, Ltd 58
Hubei Jusheng Technology Co.,Ltd 58
Nanjing Asia Pharmaceutical Technology Co., Ltd. 55
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Yancheng KangdiSen Pharmaceutical Co., Ltd. 55

View Latest Price from Ethyl 5-chloro-methyl pyrazole-4-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE pictures 2019-12-31 ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE
56984-32-8
 $6.60 1KG 97%-99% 1kg-1000kg Career Henan Chemical Co

Ethyl 5-chloro-methyl pyrazole-4-carboxylate Spectrum

ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE(56984-32-8)1HNMR

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ETHYL-5-CHLORO-1-METHYLPYRAZOLE-4-CARBOXYLATE Ethyl 5-chloropyrazole-4-carboxylate 1H-Pyrazole-4-carboxylic acid, 5-chloro-1-methyl-, ethyl ester Ethyl 5-(chloromethyl)-1H-pyrazole-4-carboxylate Ethyl 5-chloro-methyl pyrazole-4-carboxylate 56984-32-8