5-Fluoroisatin
- CAS No.
- 443-69-6
- Chemical Name:
- 5-Fluoroisatin
- Synonyms
- 5-FLUOROINDOLINE-2,3-DIONE;Fluoroisatin;5-FLUORO-1H-INDOLE-2,3-DIONE;NSC 39161;uoroisatin;5-Fluorosatin;5-FLUOROISATIN;5-FLUOROISATINE;5- fluoroindigo;5-Flluoroisatin
- CBNumber:
- CB4206497
- Molecular Formula:
- C8H4FNO2
- Molecular Weight:
- 165.12
- MDL Number:
- MFCD00022795
- MOL File:
- 443-69-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 224-227 °C (lit.) |
|---|---|
| Density | 1.477±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, DMSO, Methanol |
| pka | 8.51±0.20(Predicted) |
| form | Powder |
| color | Red |
| BRN | 131241 |
| InChI | InChI=1S/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12) |
| InChIKey | GKODDAXOSGGARJ-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(F)C=C2)C(=O)C1=O |
| CAS DataBase Reference | 443-69-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29337900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-Fluoroisatin price More Price(83)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 366978 | 5-Fluoroisatin 98% | 443-69-6 | 5g | $58.3 | 2026-04-30 | Buy |
| TCI Chemical | F0589 | 5-Fluoroisatin >98.0%(GC)(T) | 443-69-6 | 5g | $35 | 2026-04-30 | Buy |
| TCI Chemical | F0589 | 5-Fluoroisatin >98.0%(GC)(T) | 443-69-6 | 25g | $101 | 2026-04-30 | Buy |
| Usbiological | 234209 | 5-Fluoroisatin 98+% ≥98% | 25g | $206 | 2026-06-03 | Buy | |
| Usbiological | 234209 | 5-Fluoroisatin 98+% ≥98% | 100g | $245 | 2026-06-03 | Buy |
5-Fluoroisatin Chemical Properties, Uses, Production
Chemical Properties
red Crystalline Powder
Uses
It showed antibacterial and antifungal activities.
Uses
Reactant for preparation of:
- Spiro[indole-thiazolidinones] as biologically relevan synthesis scaffolds
- Potential antimycobacterial agents
- Inhibitors of c-Met kinase
- Inhibitors of TAK1 kinase
- Herpes simplex virus inhibitors
- IKKβ inhibitors
- Inhibitors of vitiligo disease
- Potential drug candidates with anti-HIV activity and anti-tubercular activity
Definition
ChEBI: 5-Fluoroisatin is a member of indoles. It has a role as an anticoronaviral agent.
General Description
5-Fluoroisatin has been reported as the precursor of the Sunitinib (Sutent) drug. 5-Fluoroisatin has been approved by the Food and Drugs Administration (FDA) in 2006 for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST).
Synthesis
351-09-7
443-69-6
Concentrated sulfuric acid (24.0 mL) was added to a dry 150 mL three-necked flask and heated to 50 °C. The intermediate synthesized above (2a-2d, 30.0 mmol) was slowly added and the color of the solution gradually deepened to black as the intermediate was added. After the addition was completed, the reaction temperature was raised to 80 °C and the reaction was maintained for 20 min. Subsequently, crushed ice (100 g) was slowly added to the reaction system, at which time the ice-water mixture showed a reddish brown color. After standing, the reaction mixture was filtered and washed with deionized water until neutral. The resulting solid was dissolved in 10.0% NaOH solution (90 mL), the pH was adjusted to 4 with concentrated hydrochloric acid and filtered. The filtrate was continued to adjust the pH to 2 with concentrated hydrochloric acid, at which time a large amount of brick red solid precipitated. The solid was collected by filtration and dried to give the reddish brown target products 3a-3d. (Elution conditions: petroleum ether: ethyl acetate, v/v = 1:2, Rf = 0.4-0.6).
References
[1] Patent: CN107033064, 2017, A. Location in patent: Paragraph 0050; 0051; 0052; 0053
[2] Journal of the Brazilian Chemical Society, 2019, vol. 30, # 1, p. 198 - 209
[3] Synthetic Communications, 1999, vol. 29, # 20, p. 3627 - 3633
[4] Medicinal Chemistry, 2016, vol. 12, # 5, p. 489 - 498
[5] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 12, p. 2919 - 2928
5-Fluoroisatin Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +1-5184799099 18755112432 | 18755112432@163.com | China | 96 | 58 |
| Hotechem Shanghai Co., Ltd., | 021-34621078 13120882795 | 465106944@qq.com | China | 859 | 56 |
| Sanover (Xiamen) Technology Co., Ltd | 请加微信(同手机号)或QQ询价 13876246362 | 422165847@qq.com | China | 498 | 58 |
| Hangzhou Chemtrue Bio-Tech Co.,Ltd. | 19967494293 | sales@chemtrue-bio.com | China | 303 | 58 |
| Qingdao Rongrong Chemical Technology Co., Ltd | 15224422002 | 2467602940@qq.com | China | 33 | 58 |
| Guangdong Daxiao Chemical Co., Ltd | 1866-171603 18666171603 | 3989665367@qq.com | China | 4982 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
View Latest Price from 5-Fluoroisatin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-18 | 5-Fluoroisatin
443-69-6
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2026-05-11 | 5-Fluoroisatin
443-69-6
|
$29.00 | 97.71% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-11 | 5-Fluoroisatin
443-69-6
|
$29.00 | 97.71% | 10g | TargetMol Chemicals Inc. |
-
- 5-Fluoroisatin
443-69-6
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 5-Fluoroisatin
443-69-6
- $29.00
- 97.71%
- TargetMol Chemicals Inc.
-
- 5-Fluoroisatin
443-69-6
- $29.00
- 97.71%
- TargetMol Chemicals Inc.
