4-[Butyl([2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl)amino]-5-pyrimidinecarboxylic acid
![4-[Butyl([2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl)amino]-5-pyrimidinecarboxylic acid Structure](CAS/GIF/141872-46-0.gif)
- CAS No.
- 141872-46-0
- Chemical Name:
- 4-[Butyl([2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl)amino]-5-pyrimidinecarboxylic acid
- Synonyms
- A81282;A 81282;A-81282;Abbott 81282;4-{butyl-[2′-(1H-tetra-zol-5-yl)-biphenyl-4-ylmethyl-]amino-}-pyrimidine-5-carboxy-lic acid;4-[Butyl([2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl)amino]-5-pyrimidinecarboxylic acid;4-(N-n-Butyl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)amino)pyrimidine-5-carboxylic acid;5-Pyrimidinecarboxylic acid, 4-[butyl[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]amino]-
- CBNumber:
- CB4213398
- Molecular Formula:
- C23H23N7O2
- Molecular Weight:
- 429.47
- MDL Number:
- MFCD00911676
- MOL File:
- 141872-46-0.mol
- MSDS File:
- SDS
4-[Butyl([2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl)amino]-5-pyrimidinecarboxylic acid Chemical Properties, Uses, Production
Uses
A-81282 (Abbott 81282) is an antagonist of angiotensin II's AT1 receptor, with a pA2 value of 9.64 at the AT1 receptor in rabbit aorta. A-81282 also demonstrates significant inhibitory action on the binding of [125i]_Sar1_lle8_Angiotensin_ll to rat liver membranes, with a pKI value of 8.505. A-81282 has antihypertensive activity and can effectively lower blood pressure in renal artery-ligated rats[1].
IC 50
AT1 Receptor: 9.64 (pA2)
References
[1] Hancock AA, et al. Pharmacological characterization of Abbott-81282, a novel, non-peptide angiotensin-II antagonist selective for type-1 receptors. Life Sci. 1993;53(11):929-37. DOI:10.1016/0024-3205(93)90445-9
4-[Butyl([2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl)amino]-5-pyrimidinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-[Butyl([2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl)amino]-5-pyrimidinecarboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-85201366 18938635012 | sales@regentsciences.com | China | 9378 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChengDu SinoStandards Bio-Tech Co.,Ltd. ， | 028-83243028 19136088901 | sinostandards@163.com | China | 4979 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29873 | 58 |
